Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment.

Autor: Antounians L; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Figueira RL; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Kukreja B; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Litvack ML; Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Zani-Ruttenstock E; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Khalaj K; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Montalva L; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Doktor F; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Obed M; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Blundell M; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Wu T; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada., Chan C; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada., Wagner R; Department of Pediatric Surgery, Leipzig University, Leipzig 04109, Germany., Lacher M; Department of Pediatric Surgery, Leipzig University, Leipzig 04109, Germany., Wilson MD; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada., Post M; Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5T 1P5, Canada., Kalish BT; Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada.; Division of Neonatology, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Zani A; Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto M5G 0A4, Canada.; Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto M5G 1X8, Canada.; Department of Surgery, University of Toronto, Toronto M5T 1P5, Canada.

Publikováno v: Science advances [Sci Adv] 2024 Jul 26; Vol. 10 (30), pp. eadn5405. Date of Electronic Publication: 2024 Jul 26.

Therapeutic stem cell-derived alveolar-like macrophages display bactericidal effects and resolve Pseudomonas aeruginosa-induced lung injury.

Autor: Bouch S; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Litvack ML; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Litman K; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada., Luo L; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Post A; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Williston E; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Park AJ; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Roach EJ; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Berezuk AM; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Khursigara CM; Department of Molecular and Cellular Biology, The University of Guelph, Ontario, Canada., Post M; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 May; Vol. 26 (10), pp. 3046-3059. Date of Electronic Publication: 2022 Apr 20.

Embryonic-Derived Myb ^- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis.

Autor: Jerkic M; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Litvack ML; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada., Gagnon S; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Otulakowski G; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada., Zhang H; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Rotstein O; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada., Kavanagh BP; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.; Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada., Post M; Translational Medicine Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada., Laffey JG; Keenan Research Centre for Biomedical Science, Unity Health Toronto St. Michael's, University of Toronto, Toronto, ON M5B 1T8, Canada.; Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Anesthesia and Critical Care Medicine, Unity Health Toronto St. Michael's, Toronto, ON M5B 1W8, Canada.; Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, School of Medicine, National University of Ireland Galway, H91 TK33 Galway, Ireland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 20; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 20.

Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish: A Unique Furan Fatty Acid (F6) and Cholesta-3,5-Diene (S5) Recruit Neutrophils and Fibroblasts to Promote Wound Healing.

Autor: Al-Hassan JM; Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait., Hinek A; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Renno WM; Department of Anatomy, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait., Wang Y; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Liu YF; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Guan R; Departments of Lab Medicine and Pathobiology, and Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Wen XY; Zebrafish Centre for Advanced Drug Discovery & Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.; Departments of Lab Medicine and Pathobiology, and Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Litvack ML; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Lindenmaier A; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Afzal M; Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait., Paul B; Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait., Oommen S; Department of Zoology, CMS College, Kottayam, India., Nair D; Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait., Kumar J; Department of Anatomy, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait., Khan MA; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada., Palaniyar N; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada.; Departments of Lab Medicine and Pathobiology, and Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Pace-Asciak C; Program in Translational Medicine, Peter Gilgan Centre for Research and Learning (PGCRL), The Hospital for Sick Children, Toronto, ON, Canada.; Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2020 Jun 18; Vol. 11, pp. 899. Date of Electronic Publication: 2020 Jun 18 (Print Publication: 2020).

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia.

Autor: Ermini L; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Ausman J; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Melland-Smith M; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Yeganeh B; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Rolfo A; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Litvack ML; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Todros T; Department of Obstetrics and Gynecology, University of Turin, Turin, 10126, Italy., Letarte M; Program in Molecular Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Post M; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada. martin.post@sickkids.ca.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. martin.post@sickkids.ca., Caniggia I; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

Publikováno v: Scientific reports [Sci Rep] 2017 Sep 22; Vol. 7 (1), pp. 12172. Date of Electronic Publication: 2017 Sep 22.