Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential.

Autor: Meshrkey F; Department of Biological Sciences, J. William Fulbright College of Arts and Sciences, University of Arkansas, Science and Engineering 601, Fayetteville, AR, 72701, USA.; Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR, USA.; Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Scheulin KM; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.; Neuroscience Program, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA, USA., Littlejohn CM; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA., Stabach J; Department of Biological Sciences, J. William Fulbright College of Arts and Sciences, University of Arkansas, Science and Engineering 601, Fayetteville, AR, 72701, USA., Saikia B; Department of Biological Sciences, J. William Fulbright College of Arts and Sciences, University of Arkansas, Science and Engineering 601, Fayetteville, AR, 72701, USA., Thorat V; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Huang Y; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA., LaFramboise T; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Lesnefsky EJ; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.; Cardiology Section Medical Service, McGuire Veterans Affairs Medical Center, Richmond, VA, USA.; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.; Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA., Rao RR; Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, AR, USA., West FD; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.; Neuroscience Program, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA, USA., Iyer S; Department of Biological Sciences, J. William Fulbright College of Arts and Sciences, University of Arkansas, Science and Engineering 601, Fayetteville, AR, 72701, USA. si012@uark.edu.; Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR, USA. si012@uark.edu.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2023 Nov 07; Vol. 14 (1), pp. 320. Date of Electronic Publication: 2023 Nov 07.