Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Liton, Kumar Saha"'
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114522- (2024)
Summary: Persistent DNA-protein crosslinks formed by human topoisomerase IIIα (TOP3A-DPCs) interfere with DNA metabolism and lead to genome damage and cell death. Recently, we demonstrated that such abortive TOP3A-DPCs are ubiquitylated and proteoly
Externí odkaz:
https://doaj.org/article/d74253d5611f45648bc092a2b6052b6d
Autor:
Sourav Saha, Shar-yin Naomi Huang, Xi Yang, Liton Kumar Saha, Yilun Sun, Prashant Khandagale, Lisa M. Jenkins, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract TOP3B is stabilized by TDRD3. Hypothesizing that TDRD3 recruits a deubiquitinase, we find that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B, and depletion of both TDRD3 and USP9X does not promote further TOP
Externí odkaz:
https://doaj.org/article/32a167d0443e46a897d892cea4d72fd8
Autor:
Liton, Kumar Saha
0048
甲第21696号
医科博第100号
新制||医科||7(附属図書館)
(主査)教授 齊藤 博英, 教授 清水 章, 教授 Shohab YOUSSEFIAN
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto Un
甲第21696号
医科博第100号
新制||医科||7(附属図書館)
(主査)教授 齊藤 博英, 教授 清水 章, 教授 Shohab YOUSSEFIAN
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto Un
Externí odkaz:
http://hdl.handle.net/2433/242428
Autor:
Christopher W Schultz, Yang Zhang, Rajaa Elmeskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon Atkinson, Liton Kumar Saha, Chien‐Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Ajit Kumar Sharma, Melissa Abel, Brett Schroeder, Manan Krishnamurthy, Rajesh Kumar, Nitin Roper, Mirit Aladjem, Frank T Zenke, Zoe Weaver Ohler, Yves Pommier, Anish Thomas
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-17 (2023)
Abstract Small‐cell lung cancer (SCLC) is the most lethal type of lung cancer. Specifically, MYC‐driven non‐neuroendocrine SCLC is particularly resistant to standard therapies. Lurbinectedin was recently approved for the treatment of relapsed S
Externí odkaz:
https://doaj.org/article/6165ccece4b14143846203745ec9358e
Autor:
Liton Kumar Saha, Sourav Saha, Xi Yang, Shar-yin Naomi Huang, Yilun Sun, Ukhyun Jo, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
This study provides evidence that human topoisomerase IIIα (TOP3A) is closely associated with active replisomes. The authors uncover TOP3A DNA cleavage complexes (TOP3Accs) repair mechanisms to ensure normal DNA replication and genome integrity.
Externí odkaz:
https://doaj.org/article/9d63d9cf54ec4c5eb9ecd3f0d8455716
Autor:
Christopher W Schultz, Yang Zhang, Rajaa Elmeskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon Atkinson, Liton Kumar Saha, Chien-Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Ajit Kumar Sharma, Melissa Abel, Brett Schroeder, Manan Krishnamurthy, Laurel L Bassel, Rajesh Kumar, Nitin Roper, Mirit Aladjem, Frank T Zenke, Zoe Weaver Ohler, Yves Pommier, Anish Thomas
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 664-664 (2024)
Externí odkaz:
https://doaj.org/article/b57ab068599f4cb395448331d2cd662b
Autor:
Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T. Kanemaki, Shinichiro Nakada, Shunichi Takeda, Hiroyuki Sasanuma
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Chemical modifications and adducts at DNA double-strand break (DSB) ends must be cleaned before re-joining by non-homologous end-joining (NHEJ). MRE11 nuclease is essential for efficient removal of Topoisomerase II (TOP2)-DNA adducts from TO
Externí odkaz:
https://doaj.org/article/8b99c7ff8a274e088ee42c1362159c13
Autor:
Yves Pommier, Woo Suk Choi, Ranjit S. Bindra, Juan C. Vasquez, Jinny Van Doorn, Ranjini K. Sundaram, Vishwas Paralkar, Kelli Jones, Sophia Gayle, Yasuhiro Arakawa, Xi Yang, Liton Kumar Saha, Yilun Sun, Keli K. Agama, Yasuhisa Murai, Ukhyun Jo
Supplementary Figure from TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7dcb1d7bd78ba120f65eb7bbd6949b
https://doi.org/10.1158/1535-7163.22523397.v1
https://doi.org/10.1158/1535-7163.22523397.v1
Autor:
Christopher W. Schultz, Yang Zhang, Rajaa Elmeskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon Atkinson, Liton Kumar Saha, Chien-Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Thomas Ried, Mirit Aladjem, Frank T. Zenke, Zoe Weaver, Yves Pommier, Anish Thomas
/SummarySmall cell lung cancer (SCLC) is the most lethal type of lung cancer. Specifically, MYC-driven non-neuroendocrine SCLC are particularly resistant to standard therapies. Lurbinectedin was recently approved for the treatment of relapsed SCLC, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7baa17c67508da9d306928855e2863d
https://doi.org/10.1101/2022.12.16.520783
https://doi.org/10.1101/2022.12.16.520783
Autor:
Ukhyun Jo, Yasuhisa Murai, Keli K. Agama, Yilun Sun, Liton Kumar Saha, Xi Yang, Yasuhiro Arakawa, Sophia Gayle, Kelli Jones, Vishwas Paralkar, Ranjini K. Sundaram, Jinny Van Doorn, Juan C. Vasquez, Ranjit S. Bindra, Woo Suk Choi, Yves Pommier
Publikováno v:
Mol Cancer Ther
Exatecan and deruxtecan are antineoplastic camptothecin derivatives in development as tumor-targeted-delivery warheads in various formulations including peptides, liposomes, polyethylene glycol nanoparticles, and antibody–drug conjugates. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6466f0700aba495f0651048d49ff2da
https://europepmc.org/articles/PMC9256811/
https://europepmc.org/articles/PMC9256811/