Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Litomosoides sigmodontis"'
Autor:
Frederic Risch, Johanna F. Scheunemann, Julia J. Reichwald, Benjamin Lenz, Alexandra Ehrens, Joséphine Gal, Frédéric Fercoq, Marianne Koschel, Martina Fendler, Achim Hoerauf, Coralie Martin, Marc P. Hübner
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently und
Externí odkaz:
https://doaj.org/article/50e2c8efd04044ce9bfe78ec3cd8f293
Autor:
Manuel Ritter, Marc P. Hübner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3d5c8dc54c5248669b298a297f1bcc64
Autor:
Johanna F. Scheunemann, Frederic Risch, Julia J. Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J. Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Vaccines, Vol 11, Iss 5, p 966 (2023)
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated infective
Externí odkaz:
https://doaj.org/article/b87d9cd8fe334b3eaac4ac43de97300f
Autor:
Julia J. Reichwald, Frederic Risch, Anna-Lena Neumann, Stefan J. Frohberger, Johanna F. Scheunemann, Benjamin Lenz, Alexandra Ehrens, Wiebke Strutz, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s during inf
Externí odkaz:
https://doaj.org/article/1acc41176560467e8afe08d122c37d69
Publikováno v:
GMS Infectious Diseases, Vol 10, p Doc02 (2022)
Filarial diseases like lymphatic filariasis and onchocerciasis belong to the Neglected Tropical Diseases and remain a public health problem in endemic countries. Lymphatic filariasis and onchocerciasis can lead to stigmatizing pathologies and present
Externí odkaz:
https://doaj.org/article/bf47990c7ab240efa9f424accec0233e
Autor:
Nadine Stetter, Wiebke Hartmann, Marie-Luise Brunn, Stephanie Stanelle-Bertram, Gülsah Gabriel, Minka Breloer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Helminths still infect a quarter of the human population. They manage to establish chronic infections by downmodulating the immune system of their hosts. Consequently, the immune response of helminth-infected individuals to vaccinations may be impair
Externí odkaz:
https://doaj.org/article/ba2e5fa5e31d4be7a2d99b0402c31a51
Autor:
Anna Wiszniewsky, Laura E. Layland, Kathrin Arndts, Lisa M. Wadephul, Ruth S. E. Tamadaho, Dennis Borrero-Wolff, Valerine C. Chunda, Chi Anizette Kien, Achim Hoerauf, Samuel Wanji, Manuel Ritter
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite long-term mass drug administration programmes, approximately 220 million people are still infected with filariae in endemic regions. Several research studies have characterized host immune responses but a major obstacle for research on human
Externí odkaz:
https://doaj.org/article/dcf93911ea2a4f10bc20e763473f133b
Autor:
Stefan J. Frohberger, Jesuthas Ajendra, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Benedikt C. Buerfent, Katrin Gentil, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Mice are susceptible to infections with the rodent filarial nematode Litomosoides sigmodontis and develop immune responses that resemble those of human filarial infections. Thus, the L. sigmodontis model is used to study filarial
Externí odkaz:
https://doaj.org/article/262c855398094f0aa02697e7a7bc880f
Autor:
Buerfent, Benedikt C., Ajendra, Jesuthas, Stamminger, Wiebke, Gondorf, Fabian, Hoerauf, Achim, Hübner, Marc P.
Publikováno v:
GMS Infectious Diseases, Vol 7, p Doc04 (2019)
TGFβ is an anti-inflammatory molecule that suppresses pro-inflammatory immune responses. Previously, we demonstrated that chronic filarial infection has a beneficial impact on -induced sepsis. In the present study, we investigated whether this prote
Externí odkaz:
https://doaj.org/article/a2d65980ecdb4a01807f8040a21da0b4
Autor:
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H.K. Chan, Jesuthas Ajendra, Alistair Chenery, Anya Morrison, Irem Kaymak, Emma L. Houlder, Syed Murtuza Baker, Ben R. Dickie, Louis Boon, Joanne E. Konkel, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Rückerl, Judith E. Allen
Publikováno v:
Finlay, C M, Parkinson, J E, Zhang, L, Chan, B H K, Ajendra, J, Chenery, A, Morrison, A, Kaymak, I, Houlder, E L, Murtuza baker, S, Dickie, B R, Boon, L, Konkel, J E, Hepworth, M R, Macdonald, A S, Randolph, G J, Rückerl, D & Allen, J E 2023, ' T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity ', Immunity, vol. 56, pp. 1–18.e1–e10 . https://doi.org/10.1016/j.immuni.2023.02.016
Finlay, C M, Parkinson, J E, Zhang, L, Chan, B H K, Ajendra, J, Chenery, A, Morrison, A, Kaymak, I, Houlder, E L, Murtuza Baker, S, Dickie, B R, Boon, L, Konkel, J E, Hepworth, M R, MacDonald, A S, Randolph, G J, Rückerl, D & Allen, J E 2023, ' T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity ', Immunity . https://doi.org/10.1016/j.immuni.2023.02.016
Finlay, C M, Parkinson, J E, Zhang, L, Chan, B H K, Ajendra, J, Chenery, A, Morrison, A, Kaymak, I, Houlder, E L, Murtuza Baker, S, Dickie, B R, Boon, L, Konkel, J E, Hepworth, M R, MacDonald, A S, Randolph, G J, Rückerl, D & Allen, J E 2023, ' T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity ', Immunity . https://doi.org/10.1016/j.immuni.2023.02.016
The recent revolution in tissue-resident macrophage biology has resulted largely from murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we analyze immune cells in the pleural cavity. Unlike C57BL/6 mice, naive tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d230903b3f29ce1b28466fde5aeb5380
https://hdl.handle.net/20.500.11820/6377fd26-84f2-41a6-8c7a-7030a6d58793
https://hdl.handle.net/20.500.11820/6377fd26-84f2-41a6-8c7a-7030a6d58793