Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Litao Xie"'
Autor:
Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Healthy expansion of adipose tissue is critical for the maintenance of metabolic health, providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently sto
Externí odkaz:
https://doaj.org/article/14ee9bf53bc94ff0b590de2094e4a81a
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 223-228 (2019)
Obesity is becoming a global epidemic, predisposing to Type 2 diabetes, cardiovascular disease, fatty liver disease, pulmonary disease, osteoarthritis and cancer. Therefore, understanding the biology of adipocyte expansion in response to overnutritio
Externí odkaz:
https://doaj.org/article/d7bf3a33e18f46e3ac79efeb74d26a2a
Autor:
Ahmad F Alghanem, Javier Abello, Joshua M Maurer, Ashutosh Kumar, Chau My Ta, Susheel K Gunasekar, Urooj Fatima, Chen Kang, Litao Xie, Oluwaseun Adeola, Megan Riker, Macaulay Elliot-Hudson, Rachel A Minerath, Chad E Grueter, Robert F Mullins, Amber N Stratman, Rajan Sah
Publikováno v:
eLife, Vol 10 (2021)
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid f
Externí odkaz:
https://doaj.org/article/078560485a37441a90c596b50ccc3063
Autor:
Ashutosh Kumar, Litao Xie, Chau My Ta, Antentor O Hinton, Susheel K Gunasekar, Rachel A Minerath, Karen Shen, Joshua M Maurer, Chad E Grueter, E Dale Abel, Gretchen Meyer, Rajan Sah
Publikováno v:
eLife, Vol 9 (2020)
Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show that SWELL1 (
Externí odkaz:
https://doaj.org/article/7f3ff750fcd64addb27a683c2c1e631a
Autor:
Steven M. Pennington, Paula R. Klutho, Litao Xie, Kim Broadhurst, Olha M. Koval, Michael L. McCormick, Douglas R. Spitz, Isabella M. Grumbach
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 401-413 (2018)
Objective: Reduction of oxidized methionines is emerging as a major protein repair pathway. The lack of methionine sulfoxide reductase A (MsrA) exacerbates cardiovascular disease phenotypes driven by increased oxidative stress. However, the role of M
Externí odkaz:
https://doaj.org/article/9d4c6889acfa42c19277977a23592a98
Autor:
Chen Kang, Litao Xie, Susheel K. Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew W. Norris, Samuel B. Stephens, Rajan Sah
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. sh
Externí odkaz:
https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc
Autor:
Jason A Scott, Paula J Klutho, Ramzi El Accaoui, Emily Nguyen, Ashlee N Venema, Litao Xie, Shuxia Jiang, Megan Dibbern, Sabrina Scroggins, Anand M Prasad, Elisabeth D Luczak, Melissa K Davis, Weiwei Li, Xiaoqun Guan, Johannes Backs, Annette J Schlueter, Robert M Weiss, Francis J Miller, Mark E Anderson, Isabella M Grumbach
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71550 (2013)
OBJECTIVE:Sustained hemodynamic stress mediated by high blood flow promotes arteriogenesis, the outward remodeling of existing arteries. Here, we examined whether Ca²⁺/calmodulin-dependent kinase II (CaMKII) regulates arteriogenesis. METHODS AND R
Externí odkaz:
https://doaj.org/article/a6212747293a4b058e5501de611d149f
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 223-228 (2019)
Adipocyte
Adipocyte
Obesity is becoming a global epidemic, predisposing to Type 2 diabetes, cardiovascular disease, fatty liver disease, pulmonary disease, osteoarthritis and cancer. Therefore, understanding the biology of adipocyte expansion in response to overnutritio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fab7a241b15b26f5f97fbfe57075a7
https://doaj.org/article/d7bf3a33e18f46e3ac79efeb74d26a2a
https://doaj.org/article/d7bf3a33e18f46e3ac79efeb74d26a2a
Autor:
Yumi Imai, Eric B. Taylor, Stephen G. Brohawn, Susheel K. Gunasekar, Norris Aw, Isaac Samuel, Pratik Rajesh Chheda, Ashok Kumar, David M Kern, Macaulay Elliot-Hudson, Robert J. Kerns, Joshua M Maurer, Rajan Sah, Chen Kang, Jessica K. Smith, Chaitanya A. Kulkarni, Grzesik Wj, My-Ta C, Litao Xie, Peter Nau, Sheldon Rd, E.E. Gerber, Lerner Dj, Yuyun Zhang
Type 2 diabetes (T2D) is associated with insulin resistance, impaired insulin secretion from the pancreatic β-cell, and nonalcoholic fatty liver disease (NAFLD). SWELL1 (LRRC8a) ablation impairs adipose and skeletal muscle insulin-pAKT2 signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3063e6f2aab7088b3277b744e9c04bd2
https://doi.org/10.1101/2021.02.28.432901
https://doi.org/10.1101/2021.02.28.432901
