Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lital Povodovski"'
Autor:
Peter Sabo, Vahagn Makaryan, Yosef Dicken, Lital Povodovski, Liat Rockah, Tzlil Bar, Matan Gabay, Dalia Elinger, Ella Segal, Ora Haimov, Maya Antoshvili, Anat London Drori, Tanoya Poulsen, Asael Herman, Rafi Emmanuel, David C. Dale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 119-131 (2022)
Severe congenital neutropenia (SCN) is a life-threatening marrow failure disorder, usually caused by heterozygous mutations in ELANE. Potential genetic treatment strategies include biallelic knockout or gene correction via homology-directed repair (H
Externí odkaz:
https://doaj.org/article/6b02eb013dc84ea08570ae9f64c22434
Autor:
Ofer Elhanani, Tomer Meir Salame, Jonathan Sobel, Dena Leshkowitz, Lital Povodovski, Itay Vaknin, Dror Kolodkin-Gal, Michael D. Walker
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of
Externí odkaz:
https://doaj.org/article/d8304aed690945eb9d1ebe06d45b0285
Autor:
Peter Sabo, Vahagn Makaryan, Yosef Dicken, Lital Povodovski, Liat Rockah, Tzlil Bar, Matan Gabay, Dalia Elinger, Ella Segal, Ora Haimov, Maya Antoshvili, Anat London Drori, Tanoya Poulsen, Asael Herman, Rafi Emmanuel, David C. Dale
Publikováno v:
Molecular therapy. Methodsclinical development. 26
Severe congenital neutropenia (SCN) is a life-threatening marrow failure disorder, usually caused by heterozygous mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32828f532c462ac3e6317ac938fe9d07
https://pubmed.ncbi.nlm.nih.gov/35795780
https://pubmed.ncbi.nlm.nih.gov/35795780
Autor:
Asael Herman, Rafi Emmanuel, Peter J. Sabo, Yosef Dicken, Lital Povodovski, David C. Dale, Vahagn Makaryan
Publikováno v:
Blood. 138:3122-3122
ELANE-related severe congenital neutropenia (SCN) is a disorder wherein numerous heterozygous mutations in the ELANE gene lead to misfolding and mislocalization of mutant neutrophil elastase, resulting in the death of myeloid cells and block in neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ea5b41c9b043a8ac1357e81fb970f2
https://doi.org/10.1182/blood-2021-149249
https://doi.org/10.1182/blood-2021-149249
Autor:
Dror Kolodkin-Gal, Dena Leshkowitz, Lital Povodovski, Ofer Elhanani, Itay Vaknin, Jonathan Sobel, Michael D. Walker, Tomer-Meir Salame
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Summary The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efbe145f4b34ae8c5e8442f725f0fe0
https://pubmed.ncbi.nlm.nih.gov/32375045
https://pubmed.ncbi.nlm.nih.gov/32375045
Autor:
Rafi Emmanuel, Tanoya Poulsen, Lital Povodovski, Yosef Dicken, Vahagn Makaryan, David C. Dale, Peter J. Sabo, Asael Herman
Publikováno v:
Blood. 136:23-23
Background: Mutations in ELANE are a cause of cyclic and severe congenital neutropenia (SCN), predominantly autosomal dominant disorders. ELANE encodes neutrophil elastase (NE), a tissue specific serine protease. Neutropenia occurs because mutant NE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e508d822985b0b7fbfb41998441c5eaa
https://doi.org/10.1182/blood-2020-137215
https://doi.org/10.1182/blood-2020-137215
Autor:
Rinat Kalaora, Lital Povodovski, Gilgi Friedlander, Ann Saada, Shani Bialik, Maya David, Yael Yoffe, Ester Feldmesser, Adi Kimchi, Elena Ainbinder
Multiple transcriptional and epigenetic changes drive differentiation of embryonic stem cells (ESCs). This study unveils an additional level of gene expression regulation involving noncanonical, cap-independent translation of a select group of mRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dedc1d6e9752cb584d737b9181ef2d8
https://europepmc.org/articles/PMC5066241/
https://europepmc.org/articles/PMC5066241/
