Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Lita A. Freeman"'
Autor:
Masaki Sato, Edward B. Neufeld, Martin P. Playford, Yu Lei, Alexander V. Sorokin, Angel M. Aponte, Lita A. Freeman, Scott M. Gordon, Amit K. Dey, Kianoush Jeiran, Masato Hamasaki, Maureen L. Sampson, Robert D. Shamburek, Jingrong Tang, Marcus Y. Chen, Kazuhiko Kotani, Josephine L.C. Anderson, Robin P.F. Dullaart, Nehal N. Mehta, Uwe J.F. Tietge, Alan T. Remaley
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
BACKGROUND Cellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not suitable as a routine clinical assay.METHODS We developed an HDL-specific phospholipid efflux (
Externí odkaz:
https://doaj.org/article/39566e9a46204437a84f2a721f256ea3
Autor:
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Lita A. Freeman, Edward B. Neufeld, Maureen L. Sampson, Rafael Zubirán, Anna Wolska, Alan T. Remaley, James D. Otvos, Margery A. Connelly
Publikováno v:
Molecules, Vol 29, Iss 3, p 564 (2024)
Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin–cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnosti
Externí odkaz:
https://doaj.org/article/7b4075c84b5d4606bf457aaea0b6e7e5
Autor:
Diego Lucero, Ozan Dikilitas, Michael M. Mendelson, Zahra Aligabi, Promotto Islam, Edward B. Neufeld, Aruna T. Bansal, Lita A. Freeman, Boris Vaisman, Jingrong Tang, Christian A. Combs, Yuesheng Li, Szilard Voros, Iftikhar J. Kullo, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100160- (2022)
A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor. To identify new genes
Externí odkaz:
https://doaj.org/article/36e2a63f6e5b47bb9ee2ec4ae8fc5638
Autor:
Edward B. Neufeld, Lita A. Freeman, Vinay Durbhakula, Maureen L. Sampson, Robert D. Shamburek, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Biology, Vol 11, Iss 8, p 1248 (2022)
Lipoprotein-X (LpX) are abnormal nephrotoxic lipoprotein particles enriched in free cholesterol and phospholipids. LpX with distinctive lipid compositions are formed in patients afflicted with either familial LCAT deficiency (FLD) or biliary cholesta
Externí odkaz:
https://doaj.org/article/6ed159cc775c49b792a6b85b47d79cc8
Autor:
Lita A. Freeman, Robert D. Shamburek, Maureen L. Sampson, Edward B. Neufeld, Masaki Sato, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 1050-1057 (2019)
Familial LCAT deficiency (FLD) patients accumulate lipoprotein-X (LP-X), an abnormal nephrotoxic lipoprotein enriched in free cholesterol (FC). The low neutral lipid content of LP-X limits the ability to detect it after separation by lipoprotein elec
Externí odkaz:
https://doaj.org/article/334e3aea938c4fc9b998b97c64d7fd77
Autor:
Marcelo J. A. Amar, Lita A. Freeman, Takafumi Nishida, Maureen L. Sampson, Milton Pryor, Boris L. Vaisman, Edward B. Neufeld, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholestero
Externí odkaz:
https://doaj.org/article/a5400b9886c54798acd3bec096f0c038
Autor:
Rafique M. Islam, Mohsen Pourmousa, Denis Sviridov, Scott M. Gordon, Edward B. Neufeld, Lita A. Freeman, B. Scott Perrin, Richard W. Pastor, Alan T. Remaley
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases. Similar to apoA-I, their atheroprotective property is attributed to their ability to
Externí odkaz:
https://doaj.org/article/f6efbe4920c04c43bd95b4e576884d48
Autor:
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2450-2457 (2013)
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible
Externí odkaz:
https://doaj.org/article/fb9a4e021ca546949a0288cce5fb182d
Autor:
Federica Basso, Lita A. Freeman, Carol Ko, Charles Joyce, Marcelo J. Amar, Robert D. Shamburek, Terese Tansey, Fairwell Thomas, Justina Wu, Beverly Paigen, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 114-126 (2007)
We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase net sterol los
Externí odkaz:
https://doaj.org/article/6b6bbb105a6d4b7691fc3ab212ba8c95
Autor:
Lita A. Freeman, Arion Kennedy, Justina Wu, Samantha Bark, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1197-1206 (2004)
The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134–142 of the AB
Externí odkaz:
https://doaj.org/article/f240ee8826674eafaaa342beb01bb3c0