Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.

Autor: de Boer C; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Armstrong Z; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.; Current address: Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Lit VAJ; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Barash U; Technion Integrated Cancer Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Ruijgrok G; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Boyango I; Technion Integrated Cancer Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Weitzenberg MM; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Schröder SP; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Sarris AJC; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Meeuwenoord NJ; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Bule P; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.; Current address: Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal., Kayal Y; Technion Integrated Cancer Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Ilan N; Technion Integrated Cancer Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Codée JDC; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Vlodavsky I; Technion Integrated Cancer Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Overkleeft HS; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands., Davies GJ; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Wu L; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.; The Rosalind Franklin Institute, Harwell, OX11 0FA, UK.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 02; Vol. 119 (31), pp. e2203167119. Date of Electronic Publication: 2022 Jul 26.