Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lissa Hooi"'
Autor:
Dexter Kai Hao Thng, Lissa Hooi, Bei En Siew, Kai-Yin Lee, Ian Jse-Wei Tan, Bettina Lieske, Norman Sihan Lin, Alfred Wei Chieh Kow, Shi Wang, Masturah Bte Mohd Abdul Rashid, Chermaine Ang, Jasmin Jia Min Koh, Tan Boon Toh, Ker-Kan Tan, Edward Kai-Hua Chow
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) is often indicative of poor prognosis, as the 5-year survival rates of patients decline rapidly. De
Externí odkaz:
https://doaj.org/article/05c0ff32920f43348fd0f9682903d3ac
Autor:
Dexter Kai Hao Thng, Lissa Hooi, Clarissa Chin Min Toh, Jhin Jieh Lim, Deepa Rajagopalan, Imran Qamar Charles Syariff, Zher Min Tan, Masturah Bte Mohd Abdul Rashid, Lei Zhou, Alfred Wei Chieh Kow, Glenn Kunnath Bonney, Brian Kim Poh Goh, Juinn Huar Kam, Sudhakar Jha, Yock Young Dan, Pierce Kah Hoe Chow, Tan Boon Toh, Edward Kai‐Hua Chow
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2275-2294 (2023)
Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone‐lysine N‐methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including
Externí odkaz:
https://doaj.org/article/626aaf793fd742a0bc57798a71194ba1
Autor:
Jhin Jieh Lim, Lissa Hooi, Yock Young Dan, Glenn K. Bonney, Lei Zhou, Pierce K.-H. Chow, Cheng Ean Chee, Tan Boon Toh, Edward K.-H. Chow
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor bortezomib has shown promising preclinical activity in HCC, clinical trials of bortezomib showed
Externí odkaz:
https://doaj.org/article/5f1d1e935a954b05bd21327460ec0650
Autor:
Agata Blasiak, Anh T. L. Truong, Alexandria Remus, Lissa Hooi, Shirley Gek Kheng Seah, Peter Wang, De Hoe Chye, Angeline Pei Chiew Lim, Kim Tien Ng, Swee Teng Teo, Yee-Joo Tan, David Michael Allen, Louis Yi Ann Chai, Wee Joo Chng, Raymond T. P. Lin, David C. B. Lye, John Eu-Li Wong, Gek-Yen Gladys Tan, Conrad En Zuo Chan, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-12 (2022)
Abstract IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a
Externí odkaz:
https://doaj.org/article/523937a2d0914dc491cce1f3ee4e42c6
Autor:
Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah‐Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai‐Hua Chow
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, the clinical success of MYC‐targeted therapies is limited. Synthetic lethality offers an alternative therapeutic strategy by
Externí odkaz:
https://doaj.org/article/77b9e0909c8e44a4a3b1672a0d0ade9b
Autor:
Yong Chun Chong, Tan Boon Toh, Zhiling Chan, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, Lissa Hooi, Zhaobing Ding, Timothy Shuen, Han Chong Toh, Yock Young Dan, Glenn Kunnath Bonney, Lei Zhou, Pierce Chow, Yulan Wang, Touati Benoukraf, Edward Kai‐Hua Chow, Weiping Han
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1362-1381 (2020)
Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development. Hepatocellular carcinoma (HCC), a malignancy that has hitherto been re
Externí odkaz:
https://doaj.org/article/455bb7e369f34263b42da99ccb4aaa1a
Autor:
Xi Yun Zhang, Deepa Rajagopalan, Tae-Hoon Chung, Lissa Hooi, Tan Boon Toh, Johann Shane Tian, Masturah Bte Mohd Abdul Rashid, Noor Rashidha Bte Meera Sahib, Mengjie Gu, Jhin Jieh Lim, Wilson Wang, Wee Joo Chng, Sudhakar Jha, Edward Kai-Hua Chow
Publikováno v:
Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-17 (2020)
Abstract Background Multiple myeloma is an incurable hematological malignancy characterized by a heterogeneous genetic and epigenetic landscape. Although a number of genetic aberrations associated with myeloma pathogenesis, progression and prognosis
Externí odkaz:
https://doaj.org/article/222d56e97dd44dc69762b54495d9888e
Autor:
Agata Blasiak, Jhin Jieh Lim, Shirley Gek Kheng Seah, Theodore Kee, Alexandria Remus, De Hoe Chye, Pui San Wong, Lissa Hooi, Anh T. L. Truong, Nguyen Le, Conrad E. Z. Chan, Rishi Desai, Xianting Ding, Brendon J. Hanson, Edward Kai‐Hua Chow, Dean Ho
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 1, Pp n/a-n/a (2021)
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to multiple drug repurposing clinical trials that have yielded largely uncertain outcomes. To overcome this challenge, we used IDentif.AI, a platform that
Externí odkaz:
https://doaj.org/article/3bdb703644b14f66b5677f820eca6cec
Autor:
Eliza Li Shan Fong, Tan Boon Toh, Quy Xiao Xuan Lin, Zheng Liu, Lissa Hooi, Masturah Bte Mohd Abdul Rashid, Touati Benoukraf, Edward Kai-Hua Chow, The Hung Huynh, Hanry Yu
Publikováno v:
Data in Brief, Vol 18, Iss , Pp 594-606 (2018)
This data article presents datasets associated with the research article entitled “Generation of matched patient-derived xenograft in vitro–in vivo models using 3D macroporous hydrogels for the study of liver cancer” (Fong et al., 2018) [1]. A
Externí odkaz:
https://doaj.org/article/ec8c804692fc4ba5884f724fef2dbd34
Autor:
Agata Blasiak, Anh T. L. Truong, Peter Wang, Lissa Hooi, De Hoe Chye, Shi-Bei Tan, Kui You, Alexandria Remus, David Michael Allen, Louis Yi Ann Chai, Conrad E.Z. Chan, David C. B. Lye, Gek-Yen G. Tan, Shirley G. K. Seah, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
ACS Nano. 16:15141-15154
Nanomedicine-based and unmodified drug interventions to address COVID-19 have evolved over the course of the pandemic as more information is gleaned and virus variants continue to emerge. For example, some early therapies (e.g., antibodies) have expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd506e481c6e9e0142c387b69d89602
https://doi.org/10.1021/acsnano.2c06366
https://doi.org/10.1021/acsnano.2c06366