Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model

Autor: Brunella Cristofaro, Lisley I. Mambelli, Luc Pardanaud, Ricardo A. Azevedo, Adilson Kleber Ferreira, Anne Eichmann, Cristiane Castilho Fernandes da Silva, Osvaldo A. Sant'Anna, Mxarcella Faria, Milene C. Menezes, Miryam Guillermina Palomino Rodriguez, Paulo Luiz de Sá Júnior, Ana Oliveira, Alexandre Keiji Tashima, Robson L. Melo, Daniela Cajado Carvalho, Fernanda C. V. Portaro

Publikováno v: Oncotarget. 11:4770-4787

Most characterized angiogenic modulators are proteolytic fragments of structural plasma and/or matrix components. Herein, we have identified a novel anti-angiogenic peptide generated by the in vitro hydrolysis of the C-terminal moiety of the fibrinog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d740eebbd653f34c28689c8e2e0c25c
https://doi.org/10.18632/oncotarget.27839

Phosphoethanolamine induces caspase-independent cell death by reducing the expression of C-RAF and inhibits tumor growth in human melanoma model

Autor: Sarah Fernandes Teixeira, Bárbara Kawamura, Salomão Dória Jorge, Ricardo A. Azevedo, Adilson Kleber Ferreira, Lisley I. Mambelli, José Alexandre Marzagão Barbuto, Renato Meneguelo

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 103

Phosphoethanolamine (PEA) is a fundamental precursor during the biosynthesis of cell membranes phospholipids. In the past few years, it has been described as a potential antitumor agent. In previous studies, we demonstrated that PEA showed antitumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb2843668e9922380fa10444aa1fd93
https://pubmed.ncbi.nlm.nih.gov/29635124

Intervening in disease through genetically-modified bacteria

Autor: Lisley I. Mambelli, Saravanan Y. Pillai, Adilson Kleber Ferreira

Publikováno v: Best practiceresearch. Clinical gastroenterology. 31(6)

The comprehension of the molecular basis of different diseases is rapidly being dissected as a consequence of advancing technology. Consequently, proteins with potential therapeutic usefulness, including cytokines and signaling molecules have been id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98fec5498814349dd85c625d3da9621
https://pubmed.ncbi.nlm.nih.gov/29566913

Early-onset breast cancer patients in the South and Southeast of Brazil should be tested for the TP53 p.R337H mutation

Autor: Maria Isabel Achatz, Karina Miranda Santiago, Amanda F. Nóbrega, Lisley I. Mambelli, Kelvin C. de Andrade, Fernanda P. Fortes

Publikováno v: Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 39, Iss 2, Pp 199-202 (2016)
Genetics and Molecular Biology, Volume: 39, Issue: 2, Pages: 199-202, Published: 24 MAY 2016
Genetics and Molecular Biology, Iss 0 (2016)

Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS), a disease that predisposes carriers to a wide variety of early onset tumors. In southern and southeastern Brazil, a high frequency of a germline TP53 mutation, p.R337H, was diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cf74c4fc2c3cbe9de51475d9fe8fcc
https://pubmed.ncbi.nlm.nih.gov/27223487

Isolation, Culture and Characterization of Stem Cells Derived from Feline Adipose Tissue and Their Multilineage Differentiation Potential

Autor: Santos, Enrico, Lisley I. Mambelli, Kerkis, Alexandre, Kerkis, Irina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28e60006dcd3ae372c3ab5d465fd78b6