Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Lisheng Dai"'
Autor:
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGenome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA damage response pathway for genome integrity maintenance. Germline mutations o
Externí odkaz:
https://doaj.org/article/0d2e5d6b71eb4b909e5643961c4ff61e
Autor:
Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 279-289 (2022)
The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we per
Externí odkaz:
https://doaj.org/article/323a20767c8b455ebfa77ffc7863939f
Autor:
Acong Yang, Tie-Juan Shao, Xavier Bofill-De Ros, Chuanjiang Lian, Patricia Villanueva, Lisheng Dai, Shuo Gu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing-
Externí odkaz:
https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f70
Autor:
Hongyan Chen, Chang Liu, Hao Jiang, Yan Gao, Mingqiang Xu, Jiawei Wang, Siyuan Liu, Yao Fu, Xulei Sun, Jiajun Xu, Jiabao Zhang, Lisheng Dai
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 2, Pp 439-450 (2017)
Background: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are members of the transforming growth factor beta (TGF-β) superfamily. Through autocrine and paracrine mechanisms, these two factors can regulate cell diff
Externí odkaz:
https://doaj.org/article/dc80b86f176848d2abe329bdb13ea119
Autor:
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 447-459.e4 (2019)
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studie
Externí odkaz:
https://doaj.org/article/ddfe0f6fd3994ce482d993e45c7ea9a6
Publikováno v:
Molecules, Vol 23, Iss 12, p 3329 (2018)
Cells frequently simultaneously express RNAs and cognate antisense transcripts without necessarily leading to the formation of RNA duplexes. Here, we present a novel transcriptome-wide experimental approach to ascertain the presence of accessible dou
Externí odkaz:
https://doaj.org/article/251cc2fa734d493a9533e06254580acf
Autor:
Bo Zhai, Huiyu Liu, Xu Li, Lisheng Dai, Yan Gao, Changhong Li, Lianjiang Zhang, Yu Ding, Xianfeng Yu, Jiabao Zhang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 2, Pp 264-278 (2013)
Background: Bone morphogenetic protein-15 (BMP15) is a maternal gene necessary for mammalian reproduction. BMP15 expression increased in oocytes accompanied by follicle growth and development. The function and regulation mechanism of BMP15 in porcine
Externí odkaz:
https://doaj.org/article/0fb9e6f11f2447309e3052fbf068035d
Autor:
Yan Gao, Fujuan Li, Yonghong Zhang, Lisheng Dai, Hao Jiang, Huiyu Liu, Shumin Zhang, Chengzhen Chen, Jiabao Zhang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 31, Iss 2-3, Pp 452-461 (2013)
Aims: Our study aims to characterize the functions of the ADIPOQ gene in the process of fat deposition of pigs, thereby providing a basis for the use of this gene as a molecular marker for pork quality. Methods: We used healthy Junmu1 piglets less th
Externí odkaz:
https://doaj.org/article/9c6d8eec8aae479c88e20e69f3c66d62
Autor:
Yurong Song, Shaneen Baxter, Lisheng Dai, Chelsea Sanders, Holli Loomans-Kropp, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Simone Difilippantonio, Ligia Pinto, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Publikováno v:
Cancer Research. 83:6518-6518
DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, PMS2, and EPCAM) play an important role in maintaining genomic stability during DNA replication and recombination. Deficiency in MMR resulting from mutations in these genes leads to mutations i
Autor:
Yurong Song, Shaneen S. Baxter, Lisheng Dai, Chelsea Sanders, Sandra Burkett, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Simone Difilippantonio, Baktiar Karim, Yuwaraj Kadariya, Ligia A. Pinto, Joseph R. Testa, Robert H. Shoemaker
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3108
Malignant mesothelioma (MMe) is a rare malignancy originating from the linings of the pleural, peritoneal and pericardial cavities. The best-defined risk factor is exposure to carcinogenic mineral fibers (e.g., asbestos). Genomic studies have reveale