Výsledky vyhledávání - "Lisette P, Yco"

Akademický článek

Identification of Kinases Responsible for p53-Dependent Autophagy

Autor: Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway, Jeffrey P. MacKeigan

Publikováno v: iScience, Vol 15, Iss , Pp 109-118 (2019)

Summary: In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor

Externí odkaz: https://doaj.org/article/1963b7c4000c4a54a648f6f246f51215

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Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death

Autor: Lisette P. Yco, Tannya R. Ibarra-Rivera, John Opoku-Ansah, André S. Bachmann, Sudhakar Ambadi, Chia-en A. Chang, Michael C. Pirrung, Christopher C. Roberts

Publikováno v: Bachmann, André S; Opoku-Ansah, John; Ibarra-Rivera, Tannya R; Yco, Lisette P; Ambadi, Sudhakar; Roberts, Christopher C; et al.(2016). Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity And Induces Tumor Cell Death.. The Journal of biological chemistry. UC Office of the President: Cancer Research Coordinating Committee (CRCC). Retrieved from: http://www.escholarship.org/uc/item/17k970vv

Multiple myeloma (MM) is an aggressive hematopoietic cancer of plasma cells. The recent emergence of three effective FDA-approved proteasome-inhibiting drugs, bortezomib (Velcade), carfilzomib (Kyprolis), and ixazomib (Ninlaro) confirms that proteaso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5b14c77794f4ecbdb56a71ba195926
https://doi.org/10.1074/jbc.m115.710053

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Identification of Kinases Responsible for p53-Dependent Autophagy

Autor: Mark E. Scott, Matthew G. Kortus, Edward Spooner, Ronan C. O'Hagan, Lisette P. Yco, Peter Fuller, Katie R. Martin, Stephanie L. Celano, Jeffrey P. MacKeigan, Stuart D. Shumway, Abigail R. Solitro, Hakan Gunaydin

Publikováno v: iScience
iScience, Vol 15, Iss, Pp 109-118 (2019)

Summary In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58c128fd3d17c9b9e3ff8373d9ea684
https://pubmed.ncbi.nlm.nih.gov/31048145

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Immunoproteasome inhibition and bioactivity of thiasyrbactins

Autor: André S. Bachmann, Christopher C. Roberts, Lisette P. Yco, Nicole A. Bakas, Chia-en A. Chang, Michael C. Pirrung, Chad R. Schultz

Publikováno v: Bioorganicmedicinal chemistry. 26(2)

A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a sulfur-for-carbon substitution to enhance synthetic accessibility and facilitate modulation of their s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea243a8e64dc5b3fe8bcdca3d9b8a021
https://pubmed.ncbi.nlm.nih.gov/29269255

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AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

Autor: Heather McClung, Mark R. Burns, Ann M. Kendzicky, Giselle L. Sholler, Ping Zhao, André S. Bachmann, Katherine Samal, Eugene W. Gerner, Lisette P. Yco

Publikováno v: International Journal of Cancer. 133:1323-1333

Neuroblastoma (NB) is associated with MYCN oncogene amplification occurring in approximately 30% of NBs and is associated with poor prognosis. MYCN is linked to a number of genes including ornithine decarboxylase (ODC), the rate-limiting enzyme in po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cce4b91efe16d4910bb7edaedf86fc40
https://doi.org/10.1002/ijc.28139

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Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Autor: Lisette P. Yco, Dirk Geerts, André S. Bachmann, Jan Koster, Gabor Mocz

Publikováno v: BMC Cancer
BMC cancer, 15(1). BioMed Central
BMC Cancer, 15. BioMed Central
Yco, L P, Geerts, D, Mocz, G, Koster, J & Bachmann, A S 2015, ' Effect of sulfasalazine on human neuroblastoma : analysis of sepiapterin reductase (SPR) as a new therapeutic target ', BMC Cancer, vol. 15, pp. 477 . https://doi.org/10.1186/s12885-015-1447-y

BACKGROUND: Neuroblastoma (NB) is an aggressive childhood malignancy in children up to 5 years of age. High-stage tumors frequently relapse even after aggressive multimodal treatment, and then show therapy resistance, typically resulting in patient d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c614c9c4411a7e0410fb83e87b95e7
http://europepmc.org/articles/PMC4475614

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PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma

Autor: Jan Koster, Lisette P. Yco, André S. Bachmann, Dirk Geerts

Publikováno v: Yco, L P, Geerts, D, Koster, J & Bachmann, A S 2013, ' PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma ', International Journal of Oncology, vol. 42, no. 4, pp. 1408-16 . https://doi.org/10.3892/ijo.2013.1836
International Journal of Oncology, 42(4), 1408-16. Spandidos Publications
International journal of oncology, 42(4), 1408-1416. Spandidos Publications

Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is a novel 19-kDa protein with four transmembrane-spanning domains that belongs to the PRAF protein family. Neuroblastoma (NB) is the most common malignant extracranial solid tumor of childhoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011e0cd15076cc9c8364a4b2ff21e918
https://research.vumc.nl/en/publications/dd19e3b9-894a-4ba3-b18e-42818b56cd1b

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AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

Autor: Katherine, Samal, Ping, Zhao, Ann, Kendzicky, Lisette P, Yco, Heather, McClung, Eugene, Gerner, Mark, Burns, André S, Bachmann, Giselle, Sholler

Publikováno v: International journal of cancer. 133(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a8fc68bc9d96a7499bcb0fce93b4a32
https://pubmed.ncbi.nlm.nih.gov/23457004

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Abstract 3323: PRAF2 regulates Rab5-dependent endocytic trafficking of EGFR in neuroblastoma

Autor: Lisette P. Yco, André S. Bachmann

Publikováno v: Cancer Research. 74:3323-3323

Receptor tyrosine kinases, such as the epidermal growth factor receptor (EGFR), mediate extracellular signaling that activates downstream cell proliferation, differentiation, and migration. Through ligand stimulation, clathrin-mediated endocytosis re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ed1993f8aa97d82faa9feaf175339f6
https://doi.org/10.1158/1538-7445.am2014-3323

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Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma

Autor: Gabor Mocz, André S. Bachmann, Lisette P. Yco, John Opoku-Ansah

Publikováno v: Biochemistry Insights
Biochemistry Insights, Vol 7 (2014)
Biochemistry Insights, Vol 2014, Iss 7, Pp 1-13 (2014)

Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that has been implicated in many human cancers and has emerged as an ideal target for cancer therapy. Withaferin A (WFA) is a natural product with promisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d25b199c021055c777f546fe305b9d3
https://doi.org/10.4137/bci.s18863

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