Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls.

Autor: Ingrida Vendele, Janet A Willment, Lisete M Silva, Angelina S Palma, Wengang Chai, Yan Liu, Ten Feizi, Maria Spyrou, Mark H T Stappers, Gordon D Brown, Neil A R Gow

Publikováno v: PLoS Pathogens, Vol 16, Iss 1, p e1007927 (2020)

During the course of fungal infection, pathogen recognition by the innate immune system is critical to initiate efficient protective immune responses. The primary event that triggers immune responses is the binding of Pattern Recognition Receptors (P

Externí odkaz: https://doaj.org/article/c5fa6d5b4b9d4571b6a61e868c7112d8

Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus

Autor: Marie N. Sorin, Antonio Di Maio, Lisete M. Silva, Domenic Ebert, Clément P. Delannoy, Ngoc-Khanh Nguyen, Yann Guerardel, Wengang Chai, Franck Halary, Karine Renaudin-Autain, Yan Liu, Céline Bressollette-Bodin, Thilo Stehle, Dorian McIlroy

Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112114- (2023)

Summary: BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, a

Externí odkaz: https://doaj.org/article/589cd137d26c40f086153d37f326313b

A novel and highly specific Forssman antigen-binding protein from sheep polyomavirus

Autor: Nils H. Rustmeier, Lisete M. Silva, Antonio Di Maio, Joshua C. Müller, Alexander Herrmann, Ten Feizi, Yan Liu, Thilo Stehle

Polyomaviruses are small, non-enveloped double-stranded DNA viruses of humans and other mammals, birds, and fish. Infections are usually asymptomatic and result in latency, however, some polyomaviruses can induce severe diseases, including cancer, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::847d7cf8228c313ca59f9c8cd094db98
https://doi.org/10.1101/2023.04.10.536218

Characterization of a glycan-binding complex of minor pilins completes the analysis of Streptococcus sanguinis type 4 pili subunits

Autor: Meriam Shahin, Devon Sheppard, Claire Raynaud, Jamie-Lee Berry, Ishwori Gurung, Lisete M. Silva, Ten Feizi, Yan Liu, Vladimir Pelicic

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (3), pp.e2216237120. ⟨10.1073/pnas.2216237120⟩

Type 4 filaments (T4F)—of which type 4 pili (T4P) are the archetype—are a superfamily of nanomachines nearly ubiquitous in prokaryotes. T4F are polymers of one major pilin, which also contain minor pilins whose roles are often poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21634286f3cf6d26c2b69d01dd0edfb
http://hdl.handle.net/10044/1/102185

Structural differences on cell wall polysaccharides of brewer's spent Saccharomyces and microarray binding profiles with immune receptors

Autor: Sofia F. Reis, Susana Messias, Rita Bastos, Vítor J. Martins, Viviana G. Correia, Benedita A. Pinheiro, Lisete M. Silva, Angelina S. Palma, Manuel A. Coimbra, Elisabete Coelho

Publikováno v: Carbohydrate polymers. 301

This work was financial supported by FCT - Fundação para a Ciência e a Tecnologia , I.P. within the project “Yeast4FoodMed” ( POCI-01-0145-FEDER-030936 and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioecon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bdd00a13d0e319625bc7bcc68bcb64
https://pubmed.ncbi.nlm.nih.gov/36446492