Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

Autor: Jeremie Vendome, Yan Ling, Roland A. Cooper, Pradeep K. Singh, Liselle F. Guiang, Elena Fernández Álvaro, Kazuyoshi Aso, Laura A. Kirkman, Björn F.C. Kafsack, Carl Nathan, Lei Shi, Rong Wang, Joseph Visone, Purnima Bhanot, Patrick K Tumwebaze, Masanori Kawasaki, Ryoma Hara, Kavitha Govindasamy, Alexis Dziedziech, George Sukenick, Hao Fan, Mayako Michino, Rei Okamoto, J. Stone Doggett, Philip J. Rosenthal, Xinran Tong, Igor Bruzual, Kenjiro Sato, Michael Foley, Toshihiro Imaeda, Laura M. Sanz, Daniel Mota, Wenhu Zhan, Gang Lin

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Proceedings of the National Academy of Sciences of the United States of America

Significance Protozoal proteasome is a validated target for antimalarial drug development, but species selectivity of reported inhibitors is suboptimal. Here we identify inhibitors with improved selectivity for malaria proteasome β5 subunit over eac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efed7ad5f1e219e76055aed62b5b9cde
https://doi.org/10.1073/pnas.1806109115