Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lise Sarah Namer"'
Autor:
Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout, Raymond Kaempfer
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that this RNA-mediated ne
Externí odkaz:
https://doaj.org/article/a21711e43d92478496d8b395fce71a1b
Autor:
Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich, Fred Schaper
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform. He
Externí odkaz:
https://doaj.org/article/fe30643aa25e4834a6e08dfbb94c75ba
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 188-200 (2017)
Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3′ UTR element that activates RNA-dependent eIF2α protein kinase (PKR). The TNF-α RNA activator, we sho
Externí odkaz:
https://doaj.org/article/b08a0644fc3049c88278087c2467dabc
Autor:
Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer, Farhat Osman
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Externí odkaz:
https://doaj.org/article/64d3508dcf124420accf8e6bb274fa61
Autor:
Fred Schaper, Anna Dittrich, Nadine Köhler, Lise Sarah Namer, Oliver Klepsch, Raymond Kaempfer
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-15 (2019)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform. Here, we st
Autor:
Farhat Osman, Lena Ilan, Lise Sarah Namer, Einav Eliahu, Smadar Cohen-Chalamish, Raymond Kaempfer, Yona Banai, Yitzhak Ben-Asouli
Publikováno v:
Cell Research. 27:688-704
Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2α (eIF2α). We demonstrate a novel, positive rol
Autor:
Lise Sarah Namer, Lena Ilan, Raymond Kaempfer, Orli Turgeman, Farhat Osman, Smadar Cohen-Chalamish
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Publikováno v:
The international journal of biochemistrycell biology. 105
Once activated by double-helical RNA, mammalian RNA-dependent stress protein kinase, PKR, phosphorylates its substrate, translation initiation factor eIF2α, to inhibit translation. eIF2α phosphorylation is critical for mounting a cellular stress re
Dynamic refolding of IFN-gamma mRNA enables it to function as PKR activator and translation template
Autor:
Dahlia Weinberg, Lise Sarah Namer, Anat Hasson, Yona Banai, Farhat Osman, Smadar Cohen-Chalamish, Raymond Kaempfer
Publikováno v:
Nature chemical biology. 5(12)
Interferon-gamma mRNA activates the RNA-dependent protein kinase PKR, which in turn strongly attenuates translation of interferon-gamma mRNA. Unlike riboswitches restricted to noncoding regions, the interferon-gamma RNA domain that activates PKR comp
Publikováno v:
Cytokine. 56:4