Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Lise Deschatelets"'
Autor:
Bassel Akache, Tyler M. Renner, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Christian Gervais, Jennifer J. Hill, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-7 (2022)
Abstract Using our strongly immunogenic SmT1 SARS-CoV-2 spike antigen platform, we developed antigens based on the Beta & Delta variants of concern (VOC). These antigens elicited higher neutralizing antibody activity to the corresponding variant than
Externí odkaz:
https://doaj.org/article/d6403fda9ca74d4599cc113bbc9a49d9
Autor:
Felicity C. Stark, Bassel Akache, Lise Deschatelets, Anh Tran, Matthew Stuible, Yves Durocher, Michael J. McCluskie, Gerard Agbayani, Renu Dudani, Blair A. Harrison, Tyler M. Renner, Shawn R. Makinen, Jegarubee Bavananthasivam, Diana Duque, Martin Gagne, Joseph Zimmermann, C. David Zarley, Terrence R. Cochrane, Martin Handfield
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract With the persistence of the SARS-CoV-2 pandemic and the emergence of novel variants, the development of novel vaccine formulations with enhanced immunogenicity profiles could help reduce disease burden in the future. Intranasally delivered v
Externí odkaz:
https://doaj.org/article/75d13e574ac142e0965e0c8633e1ee5d
Autor:
Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical studies. In particular, SLA-adjuvanted SARS-CoV-2 subunit vaccines based on trimeric spike
Externí odkaz:
https://doaj.org/article/7fefd380ab0e4f5e85bdc7345e2dcf2c
Autor:
Bassel Akache, Tyler M. Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Diana Duque, Julie Haukenfrers, Martin A. Rossotti, Francis Gaudreault, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J. McCluskie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine
Externí odkaz:
https://doaj.org/article/9618e29b6e8e4f74b75065bea762626c
Autor:
Bassel Akache, Andrew J. Read, Renu Dudani, Blair A. Harrison, Dean Williams, Lise Deschatelets, Yimei Jia, Vandana Chandan, Felicity C. Stark, Gerard Agbayani, Shawn R. Makinen, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Wei Zou, Peter D. Kirkland, Michael J. McCluskie
Publikováno v:
Vaccines, Vol 11, Iss 6, p 1043 (2023)
Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen. Rabbit hemorrhagic disease virus (RHDV)
Externí odkaz:
https://doaj.org/article/8033a136f9c84c7da76024c305c13447
Autor:
Gerard Agbayani, Yimei Jia, Bassel Akache, Vandana Chandan, Umar Iqbal, Felicity C. Stark, Lise Deschatelets, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 9, Pp 2183-2195 (2020)
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific
Externí odkaz:
https://doaj.org/article/3e7ef0b9480d48b5baae17d096234b45
Autor:
Mariam Maltseva, Yannick Galipeau, Tyler M. Renner, Lise Deschatelets, Yves Durocher, Bassel Akache, Marc-André Langlois
Publikováno v:
Vaccines, Vol 11, Iss 1, p 30 (2022)
Continuous viral evolution of SARS-CoV-2 has resulted in variants capable of immune evasion, vaccine breakthrough infections and increased transmissibility. New vaccines that invoke mucosal immunity may provide a solution to reducing virus transmissi
Externí odkaz:
https://doaj.org/article/c98aa5249a064eda9b9e42d993e5ac53
Autor:
Yimei Jia, Gerard Agbayani, Vandana Chandan, Umar Iqbal, Renu Dudani, Hui Qian, Zygmunt Jakubek, Kenneth Chan, Blair Harrison, Lise Deschatelets, Bassel Akache, Michael J. McCluskie
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2291 (2022)
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. They have classically been prepared using a thin-film hydrati
Externí odkaz:
https://doaj.org/article/9b2869dec3804fa1933b073d3c4f271c
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 12, Pp 2772-2779 (2017)
Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability and possess strong adjuvant and immunostimulatory properties making t
Externí odkaz:
https://doaj.org/article/de6817b6f35948efb347ce067493e406
Autor:
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Felicity C. Stark, Lakshmi Krishnan, Michael J. McCluskie
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 205 (2021)
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. SLA archaeosomes are a promising adjuvant candidate due to th
Externí odkaz:
https://doaj.org/article/65ffc8ded7204b35b0730b4fdff4a621