Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lise Barbé"'
Autor:
Lise Barbé, Stephanie Lam, Austin Holub, Zohreh Faghihmonzavi, Minnie Deng, Rajshri Iyer, Steven Finkbeiner
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102680- (2023)
DNA damage is a common cellular feature seen in cancer and neurodegenerative disease, but fast and accurate methods for quantifying DNA damage are lacking. Comet assays are a biochemical tool to measure DNA damage based on the migration of broken DNA
Externí odkaz:
https://doaj.org/article/3095c988dd1743c3b0b2a4f6a3259417
Autor:
Lise Barbé, Steve Finkbeiner
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Repeat diseases, such as fragile X syndrome, myotonic dystrophy, Friedreich ataxia, Huntington disease, spinocerebellar ataxias, and some forms of amyotrophic lateral sclerosis, are caused by repetitive DNA sequences that are expanded in affected ind
Externí odkaz:
https://doaj.org/article/602c0c9c94694c42a34d27589352500d
Autor:
Silvie Franck, Edouard Couvreu De Deckersberg, Jodi L. Bubenik, Christina Markouli, Lise Barbé, Joke Allemeersch, Pierre Hilven, Geoffrey Duqué, Maurice S. Swanson, Alexander Gheldof, Claudia Spits, D. Karen
Publikováno v:
Biology Open, Vol 11, Iss 1 (2022)
Skeletal muscle tissue is severely affected in myotonic dystrophy type 1 (DM1) patients, characterised by muscle weakness, myotonia and muscle immaturity in the most severe congenital form of the disease. Previously, it was not known at what stage du
Externí odkaz:
https://doaj.org/article/18c90ea6abe240b6b187510af8fdf853
Autor:
Kurt Jacobs, Filippo Zambelli, Afroditi Mertzanidou, Ilse Smolders, Mieke Geens, Ha Thi Nguyen, Lise Barbé, Karen Sermon, Claudia Spits
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 330-341 (2016)
Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked
Externí odkaz:
https://doaj.org/article/4222fde08724456886ef948b0fcfc442
Autor:
Simon Ardui, Claudia Spits, Joris Vermeesch, Geoffrey Duqué, Alexander Gheldof, Silvie Franck, Joke Allemeersch, Pierre Hilven, Dominika Dziedzicka, Fien Vanroye, Yannick De Vlaeminck, Lise Barbé, Karen Sermon
Myotonic dystrophy type 1 (DM1) is caused by expansion of a CTG repeat in the DMPK gene, where expansion size and somatic mosaicism correlates with disease severity and age of onset. While it is known that the mismatch repair protein MSH2 contributes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6affc08e28437152db51fb8118248ddd
https://biblio.vub.ac.be/vubir/msh2-knockdown-shows-ctg-repeat-stability-and-concomitant-upstream-demethylation-at-the-dmpk-locus-in-myotonic-dystrophy-type-1-human-embryonic-stem-cells(21e21ba3-53a1-42e9-a30a-9d3a7cae4a0f).html
https://biblio.vub.ac.be/vubir/msh2-knockdown-shows-ctg-repeat-stability-and-concomitant-upstream-demethylation-at-the-dmpk-locus-in-myotonic-dystrophy-type-1-human-embryonic-stem-cells(21e21ba3-53a1-42e9-a30a-9d3a7cae4a0f).html
Autor:
Patrick Shannon, Rosanna Weksberg, Ioana Miron, Kathelijne Keymolen, Jean Mathieu, Zuzana Musova, Arturo Lopez-Castel, Julie Letourneau, Michael D. Wilson, Claudia Spits, Sanaa Choufani, Minggao Liang, Silvie Franck, Stéphanie Tomé, Cynthia Gagnon, Stella Lanni, Christopher E. Pearson, David Chitayat, Sara Seneca, Karen Sermon, Lise Barbé, Zdenek Sedlacek
Publikováno v:
The American Journal of Human Genetics. 100:488-505
CTG repeat expansions in DMPK cause myotonic dystrophy (DM1) with a continuum of severity and ages of onset. Congenital DM1 (CDM1), the most severe form, presents distinct clinical features, large expansions, and almost exclusive maternal transmissio
Autor:
Mieke Geens, Kurt Jacobs, Lise Barbé, Claudia Spits, Afroditi Mertzanidou, Ha Thi Nguyen, Karen Sermon, Ilse Julia Smolders, Filippo Zambelli
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 330-341 (2016)
Stem Cell Reports
Stem Cell Reports
Summary Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification
Autor:
Srikanth Namuduri, Prateek Mehta, Lise Barbe, Stephanie Lam, Zohreh Faghihmonzavi, Steven Finkbeiner, Shekhar Bhansali
Publikováno v:
ECS Sensors Plus, Vol 3, Iss 1, p 012401 (2024)
Comet assays are used to assess the extent of Deoxyribonucleic acid (DNA) damage, in human cells, caused by substances such as novel drugs or nano materials. Deep learning is showing promising results in automating the process of quantifying the perc
Externí odkaz:
https://doaj.org/article/2f9b6116f51747a7ae0666a0c48f5344
Autor:
Lise Barbé, Dominika Dziedzicka, Karen Sermon, Claudia Spits, Mieke Geens, Christina Markouli
When aiming for homogenous embryoid body (EB) differentiation, the use of equal-sized EBs is required to avoid a size-induced differentiation bias. In this study we developed an efficient and standardized EB formation protocol for human pluripotent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecf2f815d99f1f3a8e14e2dc13c5127
https://biblio.vub.ac.be/vubir/a-high-proliferation-rate-is-critical-for-reproducible-and-standardized-embryoid-body-formation-from-laminin521based-human-pluripotent-stem-cell-cultures(bef3d2f3-4759-41c0-8792-4b8980dd7aea).html
https://biblio.vub.ac.be/vubir/a-high-proliferation-rate-is-critical-for-reproducible-and-standardized-embryoid-body-formation-from-laminin521based-human-pluripotent-stem-cell-cultures(bef3d2f3-4759-41c0-8792-4b8980dd7aea).html
Publikováno v:
Vrije Universiteit Brussel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::23ae5e499cccdad4ff80b5de0696bfe5
https://biblio.vub.ac.be/vubir/cpg-methylation-upstream-of-the-ctg-repeat-in-myotonic-dystrophy-type-1-affected-human-embryonic-stem-cell-lines-is-correlated-with-maternal-inheritance-of-the-disease-and-a-larger-expansion-size(a3057e94-6535-44d5-a75b-a0793a70fd57).html
https://biblio.vub.ac.be/vubir/cpg-methylation-upstream-of-the-ctg-repeat-in-myotonic-dystrophy-type-1-affected-human-embryonic-stem-cell-lines-is-correlated-with-maternal-inheritance-of-the-disease-and-a-larger-expansion-size(a3057e94-6535-44d5-a75b-a0793a70fd57).html