Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Lise, Hafkenscheid"'
1
Akademický článek
N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line
Autor: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to F
Externí odkaz: https://doaj.org/article/93a8586e551741e0bef6fe5c6e66c9f0
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2
Akademický článek
Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
Autor: Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall
Publikováno v: iScience, Vol 26, Iss 7, Pp 106984- (2023)
Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extra
Externí odkaz: https://doaj.org/article/5c38b67b7b324db0855f8aa5f59ead4a
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3
Akademický článek
Role of N-Glycosylation in FcγRIIIa interaction with IgG
Autor: Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG with FcγRs and the resulting effector functions, which has led to the
Externí odkaz: https://doaj.org/article/d3ca065183164628bb92e4118236f671
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4
Akademický článek
HappyTools: A software for high-throughput HPLC data processing and quantitation.
Autor: Bas Cornelis Jansen, Lise Hafkenscheid, Albert Bondt, Richard Andrew Gardner, Jenifer Lynn Hendel, Manfred Wuhrer, Daniel Ian Richard Spencer
Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200280 (2018)
High-performance liquid chromatography (HPLC) is widely used for absolute quantitation. The advent of new columns and HPLC technology has enabled higher sample throughput, and hence, larger scale studies that perform quantitation on different sample
Externí odkaz: https://doaj.org/article/76ca2a58c3074087a8706cd82c6eb7d1
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5
Galectin-1 upregulates IDO1 and PD-L1 and induces a tolerogenic tumor-associated macrophage phenotype
Autor: Asha Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias Nielsen, Caroline Mathiesen, Jesse Stoop, Sean Stowell, Per Straten, hakon lefler, Sergey Vakhrushev, Sally Dabelsteen, Jesper Olsen, Hans Wandall
Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we used an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef01bd6b8b6a229f435343027f10ee5
https://doi.org/10.21203/rs.3.rs-1936493/v1
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6
IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples
Autor: Theresa Kissel, Lise Hafkenscheid, Tineke J. Wesemael, Mami Tamai, Shin‐ya Kawashiri, Atsushi Kawakami, Hani S. El‐Gabalawy, Dirkjan van Schaardenburg, Solbritt Rantapää‐Dahlqvist, Manfred Wuhrer, Annette H. M. van der Helm‐van Mil, Cornelia F. Allaart, Diane van der Woude, Hans U. Scherer, Rene E. M. Toes, Tom W. J. Huizinga
Publikováno v: Kissel, T, Hafkenscheid, L, Wesemael, T J, Tamai, M, Kawashiri, S, Kawakami, A, el-Gabalawy, H S, van Schaardenburg, D, Rantapää-Dahlqvist, S, Wuhrer, M, van der Helm-van Mil, A H M, Allaart, C F, van der Woude, D, Scherer, H U, Toes, R E M & Huizinga, T W J 2022, ' IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter : A Cross-Sectional Study Encompassing ~1,500 Samples ', Arthritis and Rheumatology, vol. 74, no. 7, pp. 1147-1158 . https://doi.org/10.1002/art.42098
Arthritis & Rheumatolgy
Arthritis and Rheumatology, 74(7), 1147-1158. John Wiley and Sons Ltd
Kissel, T, Hafkenscheid, L, Wesemael, T J, Tamai, M, Kawashiri, S-Y, Kawakami, A, El-Gabalawy, H S, van Schaardenburg, D, Rantapää-Dahlqvist, S, Wuhrer, M, van der Helm-van Mil, A H M, Allaart, C F, van der Woude, D, Scherer, H U, Toes, R E M & Huizinga, T W J 2022, ' IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross Sectional Study Encompassing ~1,500 Samples ', Arthritis and Rheumatology, vol. 74, no. 7, pp. 1147-1158 . https://doi.org/10.1002/art.42098
Arthritis & Rheumatology, 74(7), 1147-1158. WILEY
Objective: The autoimmune response in rheumatoid arthritis (RA) is marked by the presence of anti–citrullinated protein antibodies (ACPAs). A notable feature of IgG ACPA is the abundant expression of N-linked glycans in the variable domain. However
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f367b13ff447990929d8690202733d
https://pubmed.ncbi.nlm.nih.gov/35188715
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7
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
Autor: Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S.B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J.M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W.J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E.M. Toes
Publikováno v: Science Advances, 8, 6, pp. 1-21
Science Advances, 8, 1-21
Science advances, 8(6):abm1759. American Association for the Advancement of Science
Kissel, T, Ge, C, Hafkenscheid, L, Kwekkeboom, J C, Slot, L M, Cavallari, M, He, Y, van Schie, K A, Vergroesen, R D, Kampstra, A S B, Reijm, S, Stoeken-Rijsbergen, G, Koeleman, C, Voortman, L M, Heitman, L H, Xu, B, Pruijn, G J M, Wuhrer, M, Rispens, T, Huizinga, T W J, Scherer, H U, Reth, M, Holmdahl, R & Toes, R E M 2022, ' Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation ', Science Advances, vol. 8, no. 6, abm1759 . https://doi.org/10.1126/sciadv.abm1759
Science Advances, 8(6). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances, 8(6), 1-21
The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208285deb500549af186c437aedd773
https://repository.ubn.ru.nl/handle/2066/248660
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8
OP0295 N-LINKED GLYCANS IN THE VARIABLE DOMAIN OF ACPA-IGG IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS
Autor: Lise Hafkenscheid, Xiaobo Meng, Thomas Huizinga, Manfred Wuhrer, Stacy Tanner, René E. M. Toes, Irene Smolik, Hani El-Gabalawy, Hans Scherer, Bas C. Jansen, Emma C. de Moel, Albert Bondt
Publikováno v: Oral Presentations.
Background Anti-citrullinated protein antibodies (ACPA) are disease-specific biomarkers in rheumatoid arthritis (RA). Recently, we described that more than 90% of ACPA-IgGs harbour N-linked glycans in the antibody variable (V) domain. The correspondi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::938fd23ff802483439999f8592d6ddb0
https://doi.org/10.1136/annrheumdis-2019-eular.7067
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10
The Emerging Importance of IgG Fab Glycosylation in Immunity
Autor: Yoann Rombouts, Lise Hafkenscheid, Theo Rispens, Fleur S. van de Bovenkamp
Publikováno v: Journal of immunology (Baltimore, Md.. 196(4):1435-1441
Human IgG is the most abundant glycoprotein in serum and is crucial for protective immunity. In addition to conserved IgG Fc glycans, ∼15–25% of serum IgG contains glycans within the variable domains. These so-called “Fab glycans” are primari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b12e462faf202d4a0fc7877100215bf
https://doi.org/10.4049/jimmunol.1502136
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