Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Autor: Sofie Vestergaard Fonager, Gudrun Winther, Thomas Rea Wittenborn, Lisbeth Jensen, Cecilia Fahlquist-Hagert, Lisbeth Ahm Hansen, Ernst-Martin Füchtbauer, Marina Romero-Ramos, Søren Egedal Degn

Publikováno v: Fonager, S V, Winther, G, Wittenborn, T R, Jensen, L, Fahlquist-Hagert, C, Hansen, L A, Füchtbauer, E-M, Romero-Ramos, M & Degn, S E 2022, ' Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring ', Journal of Neuroimmunology, vol. 370, 577927 . https://doi.org/10.1016/j.jneuroim.2022.577927

Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba039347c7a63e48b99862576184d6f7
https://pure.au.dk/portal/da/publications/increased-maternofoetal-transfer-of-antibodies-in-a-murine-model-of-systemic-lupus-erythematosus-but-no-immune-activation-and-neuroimmune-sequelae-in-offspring(5e13c1cc-0e1d-4d3c-9a81-c7c6d064d5ae).html

Genome Editing in Mice

Autor: Lisbeth Ahm Hansen, Ernst-Martin Füchtbauer

Publikováno v: Methods in Molecular Biology ISBN: 9781493991693

Programmable nucleases like CRISPR/Cas9 enable to edit the mouse genome directly in the zygote. Several methods have been successfully used for this. Here we describe injection into one of the pronuclei of the zygote and electroporation of zygotes. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::beb5179fd7e771fc4e28ccd497aece28
https://doi.org/10.1007/978-1-4939-9170-9_15