Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Lisbeth A. Guethlein"'
Autor:
Emily E. Wroblewski, Lisbeth A. Guethlein, Aaron G. Anderson, Weimin Liu, Yingying Li, Sara E. Heisel, Andrew Jesse Connell, Jean-Bosco N. Ndjango, Paco Bertolani, John A. Hart, Terese B. Hart, Crickette M. Sanz, David B. Morgan, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn, Peter Parham
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
A variant of MHC class I is protective against severe malaria disease and enriched in affected African populations. Here, Wroblewski et al., characterise the consequences of malaria infection in wild bonobo populations showing that the presence of ma
Externí odkaz:
https://doaj.org/article/528a72be56a540989e1b30f98ac36d3f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human NK cells are usually defined as CD3-CD56+ lymphocytes. However, a CD56-CD16+ (CD56neg) lymphocyte population that displays NK-associated markers expands during chronic viral infections such as HIV-1 and HCV, and, to lesser extent, in herpesviru
Externí odkaz:
https://doaj.org/article/7f4bb42b45d54182a0651a4c534769ac
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1886 (2021)
The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic β-cells, and in some areas of the central nervous sys
Externí odkaz:
https://doaj.org/article/1bb8ab1a02c14994a6e2bbeb424d3790
Autor:
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell f
Externí odkaz:
https://doaj.org/article/8759d92b23c14ad39042c5176a30a02a
Publikováno v:
Molecules, Vol 26, Iss 20, p 6125 (2021)
Elk-1 is a transcription factor that binds together with a dimer of the serum response factor (SRF) to the serum-response element (SRE), a genetic element that connects cellular stimulation with gene transcription. Elk-1 plays an important role in th
Externí odkaz:
https://doaj.org/article/8873477ac5cf4a43837e623b1ad0c9a2
Autor:
Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, Zakia Djaoud, Lisbeth A. Guethlein, Jeroen H. Blokhuis, Jason L. Pugh, Ana Goyos, Amir Horowitz, Rico Buchli, Ken W. Jackson, Wilfred Bardet, David A. Bushnell, Philip J. Robinson, Juan L. Mendoza, Michael E. Birnbaum, Morten Nielsen, K. Christopher Garcia, William H. Hildebrand, Peter Parham
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1394-1405 (2017)
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-co
Externí odkaz:
https://doaj.org/article/80996e0dab9f4ff09d46ee3a014674f3
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells have diverse roles in hominid immunity and reproduction. Modulating these functions are the interactions between major histocompatibility complex (MHC) class I molecules that are ligands for two NK cell surface receptor type
Externí odkaz:
https://doaj.org/article/eda653d22e114f83bf95c9ef32c0183d
Autor:
Laura A. Leaton, Jonathan Shortt, Katherine M. Kichula, Sudan Tao, Neda Nemat-Gorgani, Alexander J. Mentzer, Stephen J. Oppenheimer, Zhihui Deng, Jill A. Hollenbach, Christopher R. Gignoux, Lisbeth A. Guethlein, Peter Parham, Mary Carrington, Paul J. Norman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse popu
Externí odkaz:
https://doaj.org/article/444209174b3f4e9882d65728b9988a4f
Publikováno v:
Biochemical Society Transactions.
Long-term human diseases can shape the immune system, and natural killer (NK) cells have been documented to differentiate into distinct subsets specifically associated with chronic virus infections. One of these subsets found in large frequencies in
Autor:
Zakia Djaoud, Peter Parham, Lisbeth A. Guethlein, Daniel Olive, Bernhard B. Singer, Niassan Beyzaie, Alexander T.H. Cocker, Jason Pugh, Katherine Walwyn-Brown
γδ T cells stimulated by phosphoantigens (pAg) are potent effectors that secrete Th1 cytokines and kill tumor cells. Consequently, they are considered candidates for use in cancer immunotherapy. However, they have proven only moderately effective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2435875f180dd1f306069e0f37c5f2eb
https://doi.org/10.1158/2326-6066.c.6550517
https://doi.org/10.1158/2326-6066.c.6550517