Prioritization of genes driving congenital phenotypes of patients with de novo genomic structural variants

Autor: Sjors Middelkamp, Judith M. Vlaar, Jacques Giltay, Jerome Korzelius, Nicolle Besselink, Sander Boymans, Roel Janssen, Lisanne de la Fonteijne, Ellen van Binsbergen, Markus J. van Roosmalen, Ron Hochstenbach, Daniela Giachino, Michael E. Talkowski, Wigard P. Kloosterman, Edwin Cuppen

Publikováno v: Genome Medicine, Vol 11, Iss 1, Pp 1-15 (2019)

Abstract Background Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown. Methods We applied a combination

Externí odkaz: https://doaj.org/article/341d24bce7eb47ffb1b6902c15a0ce41

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells

Autor: Lodewyk F. A. Wessels, René Bernards, Lisanne de la Fonteijne, Sara Mainardi, Gianluca Maddalo, Edwin Cuppen, Albert J. R. Heck, Anna Ressa, Myrthe Jager, A. F. Maarten Altelaar, Joep de Ligt, Martin Fitzpatrick, Anirudh Prahallad, Stijn Groten, Evert Bosdriesz

Publikováno v: Ressa, A, Bosdriesz, E, de Ligt, J, Mainardi, S, Maddalo, G, Prahallad, A, Jager, M, de la Fonteijne, L, Fitzpatrick, M, Groten, S, Altelaar, A F M, Bernards, R, Cuppen, E, Wessels, L & Heck, A J R 2018, ' A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells ', Molecular and Cellular Proteomics, vol. 17, no. 10, pp. 1892-1908 . https://doi.org/10.1074/mcp.RA117.000486
Molecular and Cellular Proteomics, 17(10), 1892-1908. American Society for Biochemistry and Molecular Biology Inc.
Molecular & Cellular Proteomics, 17(10), 1892. American Society for Biochemistry and Molecular Biology Inc.

Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of cancer has resulted in more efficient strategies, where one or multiple drugs are adopted in no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2b62d6a87d2d6f8cfd017c5019cba
https://dspace.library.uu.nl/handle/1874/377105

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

Autor: A. F. Maarten Altelaar, Myrthe Jager, Stijn Groten, Lisanne de la Fonteijne, Lodewyk F. A. Wessels, Albert J. R. Heck, Martin Fitzpatrick, Joep de Ligt, Gianluca Maddalo, Evert Bosdriesz, Sara Mainardi, Anna Ressa, Edwin Cuppen, Anirudh Prahallad, René Bernards

Publikováno v: SSRN Electronic Journal.

Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of cancer has resulted in more efficient strategies, where one or multiple drugs are adopted in no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97a642a7b35e4b691247bce8ffad2770
https://doi.org/10.2139/ssrn.3151997