Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19

Autor: Julia Minnema, Melvin Lafeber, Roos S.G. Sablerolles, Janneke A.L. van Kempen, Lisanne Tap, Harmke A. Polinder-Bos, Bob P.A. van de Loo, Hugo van der Kuy, Miriam C. Faes, Jacomien Aleman, Jos Tournoy, Lorenz Van der Linden, Marco Gambera, Isabella Martignoni, Ronald Van Etten, Hein van Onzenoort, Mariette Kappers, Peter van Wijngaarden, Jose Verstijnen, Vera Theeuwes, Marleen Kemper, Elise Slob, Ferdi Sombogaard, Heshu Abdullah-Koolmees, Roland van den Berg, Hugo de Wit, Betul Dilek, Freija Hogenhuis, Vahid Buyukayten, Britt te Brake, Margriet Nieuwenhuijzen, Maria Scheeren, Madelief de Wit, Arjan Bulsink, Ingrid van Haelst, Peter ter Horst, Rosalie Moorlag, Anja Vos, Annemiek Otten-Helmers, Erik van Kan, Marije Voskamp, Marieke Ebbens, Marieke Ezinga, Cees van Nieuwkoop, Loes Visser, Caroline Ghazarian, Doranne Hilarius, Gonneke Hermanides, Carlinda Bresser, Judith Derijks-Engwegen, Ebbie Boemaars, Zahira Getrouw, Barbara Maat, Peter Wierenga, Tessa Bosch, Lisanne Krens, Kajie Liang, Langeza Saleh, Milou van Heuckelum, Linda Hendriksen, Paul van der Linden, Kaylen Guda, Kristel Crommentuijn, Ilse Cornelissen-Wesseling, Jeroen Diepstraten, Jacobien Ellerbroek, Saskia Coenradie, Debbie Deben, Kim Hurkens, Dennis Wong, Marion Vromen, Marjolein de Bock, Suzan Savelkoul, Saskia Wolters, Louise Andrews, Eefje Jong, Rosanne Kranenburg, Joana Soares, Fatima Falcao, Mariana Solano, Erica Viegas, Margarida Falcao, Helena Farinha, Dina Mendes, Joao Rijo, Marta Miarons, Maria Queralt Gorgas, Cristina García Yubero, Laura Portillo Horcajada, Kim Keijzers, Silke Lim, Linden Ashfield, Helen Bell, Naomi Fitzhugh, Glenda Fleming, Nicola Goodfellow, Joanne Hanley, Michael Scott, Simon P. Mooijaart, Jacobijn Gussekloo, Petra Elders, Geeske Peeters

Publikováno v: Heliyon, Vol 10, Iss 23, Pp e40456- (2024)

Background: The clinical frailty scale (CFS) was used as a triage tool for medical decision making during the COVID-19 pandemic. The CFS has been posed as a suitable risk marker for in-hospital mortality in COVID-19 patients. We evaluated whether the

Externí odkaz: https://doaj.org/article/c6e84359db6c419a80d153ef70cdacce

Abstract 1846: Co-treatment with simvastatin and cetuximab in KRAS mutant LoVo cells decreases PTK activity effectively and increases STK activity to overcome the anti-EGFR resistance

Autor: Henk-Jan Guchelaar, Lisanne Krens, Monique Mommersteeg, Renee Pablo-Baak, Tahar van der Straaten, Maria Helena Hilhorst, Rob Ruijtenbeek

Publikováno v: Cancer Research. 74:1846-1846

Background: 40% of colorectal cancer patients have mutations in the KRAS gene, resulting in auto activation of KRAS and EGFR independent proliferation. Those patients are excluded from therapy with anti-EGFR antibodies. Activation of KRAS depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ee9ed3554f6a95b18cf3eacc5f87605
https://doi.org/10.1158/1538-7445.am2014-1846