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Autor:
Marc Schmidt-Supprian, Kristin Müller, Beate Lembrich, Manolis Pasparakis, Stijn Stroobants, Barry J. Bedell, Hartwig Wolburg, Lydia Sorokin, Markus Schwaninger, François Truchetet, Kathrin Töllner, Dirk Rades, Xin-Kang Tong, Jan Wenzel, Tobias Weber, Rudi D'Hooge, Lisanne Fischer, Panayiota Papadopoulos, Wolfgang Löscher, Cristina Elena Niturad, Dirk A. Ridder, Marilyn Grand'Maison, Julian C. Assmann, Eva Korpos, Edith Hamel, Detlef Balschun
Publikováno v:
The Journal of Experimental Medicine
Ridder et al. show that deletion of NEMO, a component of NF-kB signaling, in brain endothelial cells results in increased cerebral vascular permeability and endothelial cell death, and recapitulates the neurological symptoms observed in the genetic d