Ad26.RSV.preF completely protects calves from severe respiratory disease induced by bovine RSV challenge

Autor: Leslie van der Fits, Rineke de Jong, Karin Dijkman, Marjolein Heemskerk-van der Meer, Lisanne Tettero, Judith Bonsing, Sophie van Oort, Jan Serroyen, Marianke van Schie, Norbert Stockhofe-Zurwieden, Benoit Callendret, Roland Zahn

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)

Abstract Vaccination with Ad26.RSV.preF, an Adenoviral serotype 26 vector encoding RSV F protein stabilized in its prefusion conformation, has previously shown to be immunogenic and protective in RSV seropositive adults and immunogenic in seropositiv

Externí odkaz: https://doaj.org/article/8b15c10cd47a4cbcb11b6592cfaf8b91

Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G

Autor: Richard Voorzaat, Freek Cox, Daan van Overveld, Lam Le, Lisanne Tettero, Joost Vaneman, Mark J. G. Bakkers, Johannes P. M. Langedijk

Publikováno v: Vaccines, Vol 12, Iss 3, p 294 (2024)

Human respiratory syncytial virus (RSV) poses a significant human health threat, particularly to infants and the elderly. While efficacious vaccines based on the F protein have recently received market authorization, uncertainties remain regarding th

Externí odkaz: https://doaj.org/article/7b3cd1758c084380a03c5b0855313ad3

Immunogenicity and protective efficacy of adenoviral and subunit RSV vaccines based on stabilized prefusion F protein in pre-clinical models

Autor: Eirikur, Saeland, Leslie, van der Fits, Renske, Bolder, Marjolein, Heemskerk-van der Meer, Joke, Drijver, Yolinda, van Polanen, Cornelis, Vaneman, Lisanne, Tettero, Jan, Serroyen, Hanneke, Schuitemaker, Benoit, Callendret, Johannes P M, Langedijk, Roland C, Zahn

Publikováno v: Vaccine. 40:934-944

Respiratory Syncytial Virus (RSV) remains a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously described the derivation of an RSV Fusion protein (F) stabilized in its prefusion conformation (pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe85a0942ed5591d0c8fc20b75986b6
https://doi.org/10.1016/j.vaccine.2021.12.043

Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge

Autor: Johan W. A. Verspuij, Petra Mooij, Harmjan Kuipers, Lisanne Tettero, Jeroen Huizingh, Liesbeth Dekking, Daniella Mortier, Jeroen Tolboom, Sonja P. R. Schmit-Tillemans, Hanneke Schuitemaker, Ted Kwaks, Willy M. J. M. Bogers, Gerrit Koopman, Joan E. M. van der Lubbe, Ramon Roozendaal, Boerries Brandenburg, Roland Zahn, Wim Meijberg

Publikováno v: npj Vaccines, 3(1):25. Nature Publishing Group
npj Vaccines, Vol 3, Iss 1, Pp 1-9 (2018)
NPJ Vaccines

Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37afb0217a019f93d61a111b27c02f43
https://pure.amc.nl/en/publications/minihemagglutinin-vaccination-induces-crossreactive-antibodies-in-preexposed-nhp-that-protect-mice-against-lethal-influenza-challenge(7ece9426-b1a1-4714-a24c-94e3d26594c7).html

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Autor: Katarina Radosevic, Patrick Wanningen, Martijn de Man, Jeroen Tolboom, Jaap Goudsmit, Wouter Koudstaal, Liesbeth Dekking, Xueyong Zhu, Antonietta Impagliazzo, Başak Kükrer, Lisanne Tettero, Jeroen Huizingh, Ryan M. B. Hoffman, Harmjan Kuipers, Ian A. Wilson, Michelle Wagner, Peter Lee, Wim Meijberg, Adrian Apetri, Wenli Yu, Andrew B. Ward, Fin Milder, Nick S. Laursen, Ruud van Meersbergen, Eveline Sneekes-Vriese, Johan Verspuij, Sander van Meerten, Danuta Tomkiewicz, Zhaoqing Ding, Anna Zakrzewska

Publikováno v: Science, 349(6254), 1301-1306. American Association for the Advancement of Science
Impagliazzo, A, Milder, F, Kuipers, H, Wagner, M V, Zhu, X, Hoffman, R M B, van Meersbergen, R, Huizingh, J, Wanningen, P, Verspuij, J, de Man, M, Ding, Z, Apetri, A, Kükrer, B, Sneekes-Vriese, E, Tomkiewicz, D, Laursen, N S, Lee, P S, Zakrzewska, A, Dekking, L, Tolboom, J, Tettero, L, van Meerten, S, Yu, W, Koudstaal, W, Goudsmit, J, Ward, A B, Meijberg, W, Wilson, I A & Radošević, K 2015, ' A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen ', Science, vol. 349, no. 6254, pp. 1301-1306 . https://doi.org/10.1126/science.aac7263

Flu vaccine candidate STEMs the tide Every year we need a new flu vaccine, because influenza virus constantly mutates the major target of antibodies to flu: the “head” region of the viral hemagglutinin (HA) protein. Avoiding the problem of mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5e966ec4eee967328572874fdaffcc
https://pure.amc.nl/en/publications/a-stable-trimeric-influenza-hemagglutinin-stem-as-a-broadly-protective-immunogen(f8e04c0c-f347-468c-81ca-21b0481e94eb).html