Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lisa-Marie Ramirez"'
Autor:
Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Viet H. Man, Haiqiong Ye, Yue Han, Yunfei Liu, Ping Li, Zhengding Su, Junmei Wang, Hanbin Mao, Markus Zweckstetter, Sarah Perrett, Si Wu, Meng Gao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Preventing tau aggregation is a potential therapeutic strategy in Alzheimer’s disease and other tauopathies. Recently, liquid–liquid phase separation has been found to facilitate the formation of pathogenic tau conformations and fibrilla
Externí odkaz:
https://doaj.org/article/f29b0f1178684b23b9c392b3ba2dbc9b
Autor:
Isabelle Aillaud, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funke
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2022)
Abstract Background Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that mainly affects older adults. One of the pathological hallmarks of AD is abnormally aggregated Tau protein that forms fi
Externí odkaz:
https://doaj.org/article/be7a9b4f92e14cbdb3ebad08765e0077
Publikováno v:
Current opinion in chemical biology 74, 102304 (2023). doi:10.1016/j.cbpa.2023.102304
Proteostasis is maintained by a network of molecular chaperones, a prominent member of which is the 90-kilodalton heat shock protein Hsp90. The chaperone function of Hsp90 has been extensively reviewed previously, emphasizing its ATPase activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06076061115a4a60707390acab22c2eb
Autor:
Antonia Moll, Lisa Marie Ramirez, Momchil Ninov, Juliane Schwarz, Henning Urlaub, Markus Zweckstetter
Publikováno v:
Nature Communications
Nature Communications 13(1), 3668 (2022). doi:10.1038/s41467-022-31396-z
Nature Communications 13(1), 3668 (2022). doi:10.1038/s41467-022-31396-z
Alzheimer’s disease is a neurodegenerative disorder in which misfolding and aggregation of pathologically modified Tau is critical for neuronal dysfunction and degeneration. The two central chaperones Hsp70 and Hsp90 coordinate protein homeostasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cf72f27f88e54698b2ed7a52acd262
https://doi.org/10.1101/2022.03.18.484853
https://doi.org/10.1101/2022.03.18.484853
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e4676d5618d4e715742ab807a3fd10
https://doi.org/10.1096/fasebj.20.4.a588-d
https://doi.org/10.1096/fasebj.20.4.a588-d