Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lisa-Marie Funk"'
Autor:
Lisa-Marie Funk, Gereon Poschmann, Fabian Rabe von Pappenheim, Ashwin Chari, Kim M. Stegmann, Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in viral replication, has been val
Externí odkaz:
https://doaj.org/article/721e5465cdfb4b73a39d8f7ff2da8167
Autor:
Kai Tittmann, Lisa-Marie Funk, Fabian Rabe von Pappenheim, Marie Wensien, Nora Eulig, Elke Penka, Kim Stegmann, Antje Dickmanns, Matthias Dobbelstein, Ricardo Mata, Jon Uranga, Sophia Bazzi, Tobias Fritz, Ashwin Chari, Elham Paknia, Gaby Heyne, Arwen Pearson, Rolf Hilgenfeld, Ute Curth, Carsten Berndt, Gereon Poschmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52d5429e39701bce7669e6b07b16574
https://doi.org/10.21203/rs.3.rs-2341326/v1
https://doi.org/10.21203/rs.3.rs-2341326/v1
Autor:
Lisa-Marie Funk, Gereon Poschmann, Ashwin Chari, Fabian Rabe von Pappenheim, Kim-Maren Stegmann, Antje Dickmanns, Nora Eulig, Marie Wensien, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c180ad7c9a84e59bc5f1117bc181f463
https://doi.org/10.1101/2022.04.18.487732
https://doi.org/10.1101/2022.04.18.487732
Autor:
Franziska Seifert, Stephan Schilling, Oliver Kupski, Hans-Ulrich Demuth, Lisa-Marie Funk, Viktor Sautner, Franc Meyer, Ulf Diederichsen, Brigitte Worbs, Daniel Ramsbeck, Mirko Buchholz, Kai Tittmann
Publikováno v:
Biochemistry. 59:2585-2591
Amyloidogenic plaques are hallmarks of Alzheimer's disease (AD) and typically consist of high percentages of modified Aβ peptides bearing N-terminally cyclized glutamate residues. The human zinc(II) enzyme glutaminyl cyclase (QC) was shown in vivo t
Autor:
Fabian Rabe von Pappenheim, Marie Wensien, Jin Ye, Jon Uranga, Iker Irisarri, Jan de Vries, Lisa-Marie Funk, Ricardo A. Mata, Kai Tittmann
Publikováno v:
Nature chemical biology 18, 368 – 375 (2022). doi:10.1038/s41589-021-00966-5
Nature chemical biology 18, 368 – 375 (2022). doi:10.1038/s41589-021-00966-5
We recently reported the discovery of a lysine–cysteine redox switch in proteins with a covalent nitrogen–oxygen–sulfur (NOS) bridge. Here, a systematic survey
We recently reported the discovery of a lysine–cysteine redox switch in proteins with a covalent nitrogen–oxygen–sulfur (NOS) bridge. Here, a systematic survey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abe506b1cea8e4b7a3300525a5e31bb
Autor:
Andreas Meyer, Annemarie Kehl, Chang Cui, Fehmke A. K. Reichardt, Fabian Hecker, Lisa-Marie Funk, Manas K. Ghosh, Kuan-Ting Pan, Henning Urlaub, Kai Tittmann, JoAnne Stubbe, Marina Bennati
Publikováno v:
Journal of the American Chemical Society
Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, thereby playing a key role in DNA replication and repair. Escherichia coli class Ia RNR is an α2β2 enzyme complex that uses a reversible multistep r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ae7da97f471aecad15672c5fd97a2f
https://hdl.handle.net/21.11116/0000-000A-E2CB-221.11116/0000-000A-E2CD-0
https://hdl.handle.net/21.11116/0000-000A-E2CB-221.11116/0000-000A-E2CD-0
Autor:
M. Wensien, Kai Tittmann, Lisa-Marie Funk, Jon Uranga, Fabian Rabe von Pappenheim, Ricardo A. Mata, Jin Ye
We recently reported on the discovery of a lysine-cysteine redox switch in proteins with a covalent NOS bridge. Here, a systematic survey of the whole protein structure database discloses that NOS bridges are ubiquitous, hitherto overlooked redox swi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6317d938a631bce8eff62a927c6b05d5
https://doi.org/10.21203/rs.3.rs-635771/v1
https://doi.org/10.21203/rs.3.rs-635771/v1
Autor:
Fabian Rabe von Pappenheim, Kai Tittmann, Ulf Diederichsen, Henning Urlaub, Viktor Sautner, M. Wensien, Pan Fang, Ute Curth, Jin Ye, Ricardo A. Mata, Jon Uranga, Lisa-Marie Funk, Kuan-Ting Pan, Patrick Kloskowski
Publikováno v:
Nature 593(7859), 460-464 (2021). doi:10.1038/s41586-021-03513-3
Nature 593(7859), 460 - 464 (2021). doi:10.1038/s41586-021-03513-3
Disulfide bonds between cysteine residues are important post-translational modifications in proteins that have critical roles for protein structure and stability, as redox-active
Disulfide bonds between cysteine residues are important post-translational modifications in proteins that have critical roles for protein structure and stability, as redox-active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b907a825dee6e1b58031f42e6c61859
https://bib-pubdb1.desy.de/record/459162
https://bib-pubdb1.desy.de/record/459162
Publikováno v:
Zeitschrift für Didaktik der Biologie - Biologie Lehren und Lernen, Vol 27 (2023)
Die zunehmende weltweite Plastikproduktion führt dazu, dass sich in allen Ökosystemen Mikroplastik anreichert, ohne abge-baut zu werden. Während das Recycling von Makroplastik seit Jahrzehnten in der Umweltbildung verankert ist, geraten durch aktu
Externí odkaz:
https://doaj.org/article/e6d8de99925a4a7fb0372e7e741d912d
Autor:
Benjamin Schröder, Fabian Rabe von Pappenheim, Shaobo Dai, Lisa-Marie Funk, Viktor Sautner, Jon Uranga, Ricardo A. Mata, Kai Tittmann, Mirko Paulikat
Publikováno v:
Nature. 573(7775)
The underlying molecular mechanisms of cooperativity and allosteric regulation are well understood for many proteins, with haemoglobin and aspartate transcarbamoylase serving as prototypical examples1,2. The binding of effectors typically causes a st