Výsledky vyhledávání - "Lisa-Marie Appel"

Akademický článek

Cytosolic nucleic acid sensors and interferon beta-1 activation drive radiation-induced anti-tumour immune effects in human pancreatic cancer cells

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionPancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths worldwide with limited treatment options due to extensive radiation and chemotherapy resistance. Monotherapy with immune checkpoint blockade showed n

Externí odkaz: https://doaj.org/article/3025e223cab047d6828e139b1e21af01

Zobrazit plný text záznamu

Akademický článek

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation

Autor: Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Transcription is regulated by a multitude of activators and repressors, which bind to the RNA polymerase II (Pol II) machinery and modulate its progression. Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue pr

Externí odkaz: https://doaj.org/article/7e2958cf4ca145b5b98cf2019cfa7806

Zobrazit plný text záznamu

Akademický článek

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Autor: Lisa-Marie Appel, Vedran Franke, Johannes Benedum, Irina Grishkovskaya, Xué Strobl, Anton Polyansky, Gregor Ammann, Sebastian Platzer, Andrea Neudolt, Anna Wunder, Lena Walch, Stefanie Kaiser, Bojan Zagrovic, Kristina Djinovic-Carugo, Altuna Akalin, Dea Slade

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Here the authors establish the SPOC domain as a universal reader of the RNA Pol II CTD code and a versatile reader of phosphoserine marks found in co- and post-transcriptional regulators such as m6A writer and reader proteins.

Externí odkaz: https://doaj.org/article/c385ebe5d8ab489ea14decc0dad9379b

Zobrazit plný text záznamu

Akademický článek

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)

Here the authors identify PHF3 SPOC domain as a reader of the phosphorylated RNA polymerase II (Pol II) C-terminal domain. They show that PHF3 clusters with Pol II complexes in cells, drives phase separation of Pol II in vitro, and regulates neuronal

Externí odkaz: https://doaj.org/article/248ef7e0ffd543019b8945fa5bb593d6

Zobrazit plný text záznamu

SPOC domain proteins in health and disease

Autor: Lisa-Marie Appel, Johannes Benedum, Magdalena Engl, Sebastian Platzer, Alexander Schleiffer, Xué Strobl, Dea Slade

Publikováno v: Genes & Development. 37:140-170

Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20df419ae8de85294359e86eef1fcc92
https://doi.org/10.1101/gad.350314.122

Zobrazit plný text záznamu

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Autor: Lisa-Marie Appel, Irina Grishkovskaya, Johannes Benedum, Vedran Franke, Anton Polyansky, Andrea Neudolt, Anna Wunder, Bojan Zagrovic, Altuna Akalin, Kristina Djinovic-Carugo, Dea Slade

The heptarepeats of the C-terminal domain (CTD) of RNA polymerase II (Pol II) are extensively modified throughout the transcription cycle. The CTD coordinates RNA synthesis and processing by recruiting transcription regulation factors as well as RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e731145958750e0e3031211f34d394fd
https://doi.org/10.1101/2022.02.26.482114

Zobrazit plný text záznamu

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks ont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684420fa3a6b9d0b1c365744254e08a1
https://doi.org/10.1038/s41467-021-26360-2

Zobrazit plný text záznamu

PHF3 Regulates Neuronal Gene Expression Through the New Pol II CTD Reader Domain SPOC

Publikováno v: SSRN Electronic Journal.

SUMMARYThe C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a new CTD-binding factor that negatively regulates tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8083fa6bf92a25146a4f9e49d7ed067a
https://doi.org/10.2139/ssrn.3543843

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání