Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lisa von Kleist"'
Autor:
Mukhran Khundadze, Federico Ribaudo, Adeela Hussain, Jan Rosentreter, Sandor Nietzsche, Melanie Thelen, Dominic Winter, Birgit Hoffmann, Muhammad Awais Afzal, Tanja Hermann, Cecilia de Heus, Eva-Maria Piskor, Christian Kosan, Patricia Franzka, Lisa von Kleist, Tobias Stauber, Judith Klumperman, Markus Damme, Tassula Proikas-Cezanne, Christian A. Hübner
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 419-431 (2019)
Hereditary spastic paraplegia is a spastic gait disorder that arises from degeneration of corticospinal axons. The subtype SPG48 is associated with mutations in the zeta subunit of the adaptor protein complex five (AP5). AP5 function and the pathophy
Externí odkaz:
https://doaj.org/article/c5d0d4197e294f66a8340361edbe5c4c
Autor:
Judith Klumperman, Christian A. Hübner, Jan Rosentreter, Muhammad Awais Afzal, Christian Kosan, Melanie Thelen, Birgit Hoffmann, Markus Damme, Tassula Proikas-Cezanne, Adeela Hussain, Lisa von Kleist, Sandor Nietzsche, Patricia Franzka, Federico Ribaudo, Cecilia de Heus, Eva-Maria Piskor, Tanja Hermann, Dominic Winter, Tobias Stauber, Mukhran Khundadze
Publikováno v:
Neurobiology of Disease, Vol 127, Iss, Pp 419-431 (2019)
Hereditary spastic paraplegia is a spastic gait disorder that arises from degeneration of corticospinal axons. The subtype SPG48 is associated with mutations in the zeta subunit of the adaptor protein complex five (AP5). AP5 function and the pathophy
Autor:
Jennifer L. Stow, Ann H. Kwan, Jing Xue, Joel P. Mackay, Roland Gamsjaeger, Phillip J. Robinson, Jerome Wielens, Lin Luo, Liza Cubeddu, Michael W. Parker, Lisa von Kleist, Zhong Guo
Publikováno v:
Journal of Biological Chemistry. 291:9411-9424
Dynamin is a GTPase that mediates vesicle fission during synaptic vesicle endocytosis. Its long C-terminal proline-rich domain contains 13 PXXP motifs, which orchestrate its interactions with multiple proteins. The SH3 domains of syndapin and endophi
Autor:
Ngoc Chau, Phillip J. Robinson, Wiebke Stahlschmidt, Jennifer R. Baker, Adam McCluskey, Ainslie Whiting, Volker Haucke, Mark J. Robertson, Lisa von Kleist, Marc Nazaré, André Horatscheck, Samantha Sauer
Publikováno v:
Organic & Biomolecular Chemistry. 14:11266-11278
The development of a (Z)-5-((6,8-dichloro-4-oxo-4H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one (2), rhodanine-based lead that led to the Pitstop® 2 family of clathrin inhibitors is described herein. Head group substitution and bioisosteric rep
Autor:
Ingke Braren, Tobias Stauber, Stephan Storch, Khandsuren Ariunbat, Tatyana Danyukova, Lisa von Kleist
Publikováno v:
Supportive Care in Cancer
Molecular Genetics and Metabolism
Molecular Genetics and Metabolism
Mutations in the CLN7/MFSD8 gene encoding the lysosomal membrane protein CLN7 are causative of CLN7 disease, an inherited neurodegenerative disorder that typically affects children. To gain insight into the pathomechanisms of CLN7 disease, we establi
Publikováno v:
Fluorescence Imaging and Biological Quantification ISBN: 9781315121017
This chapter provides the optical measurement of the ion concentrations and the transmembrane potential of lysosomes. There are vast possibilities to measure ion concentrations using fluorescent ion sensors. The low pH is important for the activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559798f0bc64fc6188796fbe4ca4df79
https://doi.org/10.1201/9781315121017-14
https://doi.org/10.1201/9781315121017-14
Autor:
Shannon R. Joseph, James A. Daniel, Phillip J. Robinson, Peter Maamary, Adam McCluskey, Sai Krishnan, Lingbo Hu, Lisa von Kleist, Ainslie Whiting, Volker Haucke, Ngoc Chau, Fiona Simpson, Mohammed K. Abdel-Hamid
Publikováno v:
Traffic. 16:635-654
Chlorpromazine is a phenothiazine-derived antipsychotic drug (APD) that inhibits clathrin-mediated endocytosis (CME) in cells by an unknown mechanism. We examined whether its action and that of other APDs might be mediated by the GTPase activity of d
Autor:
Volker Haucke, Lisa von Kleist, Mark J. Robertson, Adam McCluskey, Wiebke Stahlschmidt, Phillip J. Robinson, Fiona M. Deane
Publikováno v:
Nature Protocols. 9:1592-1606
This protocol describes the synthesis of two classes of clathrin inhibitors, Pitstop 1 and Pitstop 2, along with two inactive analogs that can be used as negative controls (Pitstop inactive controls, Pitnot-2 and Pitnot-2-100). Pitstop-induced inhibi
Autor:
Mark J. Robertson, Wiebke Stahlschmidt, Kylie A. MacGregor, Phillip J. Robinson, Lisa von Kleist, Adam McCluskey, Ngoc Chau, Kelly A. Young, Ainslie Whiting, Volker Haucke
Publikováno v:
Journal of Medicinal Chemistry. 57:131-143
We reported the first small molecule inhibitors of the interaction between the clathrin N-terminal domain (TD) and endocyctic accessory proteins (i.e., clathrin inhibition1). Initial screening of a ∼17 000 small molecule ChemBioNet library identifi
Autor:
Antonio Palmeri, Erik Duelsner, Olivier Leclercq, Lisa von Kleist, Manuela Helmer-Citterich, Gerald F. Späth, Sabine Baumgart, Pier Federico Gherardini, Kathrin Bartho
Publikováno v:
Journal of Proteomics; Vol 86
Journal of Proteomics
Journal of Proteomics, Elsevier, 2013, 86, pp.97-104. ⟨10.1016/j.jprot.2013.05.002⟩
Journal of Proteomics, 2013, 86, pp.97-104. ⟨10.1016/j.jprot.2013.05.002⟩
Journal of Proteomics
Journal of Proteomics, Elsevier, 2013, 86, pp.97-104. ⟨10.1016/j.jprot.2013.05.002⟩
Journal of Proteomics, 2013, 86, pp.97-104. ⟨10.1016/j.jprot.2013.05.002⟩
International audience; Trypanosomatid parasites of the genus Leishmania cause severe human diseases collectively termed leishmaniasis. Parasite ATP-binding proteins have emerged as potent targets for chemotherapeutic intervention. However, many para