Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis

Autor: Bernard M. J. Uitdehaag, Timo K. van den Berg, Rianka P. M. Vloet, Roeland Hanemaaijer, Charlotte E. Teunissen, Holger Jon Møller, Babs O. Fabriek, Christine D. Dijkstra, Lisa van Winsen

Publikováno v: Journal of Neuroimmunology, 187(1-2), 179-86. Elsevier
Journal of neuroimmunology, 187(1-2), 179-186. Elsevier
Fabriek, B O, Møller, H J, Vloet, R P M, van Winsen, L M, Hanemaaijer, R, Teunissen, C E, Uitdehaag, B M J, van den Berg, T K & Dijkstra, C D 2007, ' Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis. ', Journal of Neuroimmunology, vol. 187, no. 1-2, pp. 179-86 . https://doi.org/10.1016/j.jneuroim.2007.04.016
Fabriek, B O, Møller, H J, Vloet, R P M, van Winsen, L M, Hanemaaijer, R, Teunissen, C E, Uitdehaag, B M J, van den Berg, T K & Dijkstra, C D 2007, ' Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis ', Journal of Neuroimmunology, vol. 187, no. 1-2, pp. 179-86 . https://doi.org/10.1016/j.jneuroim.2007.04.016

The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f3f013909410976458a9d715998b89
https://doi.org/10.1016/j.jneuroim.2007.04.016

Suppressive effect of glucocorticoids on TNF-alpha production is associated with their clinical effect in multiple sclerosis

Autor: Fred J.H. Tilders, Christine D. Dijkstra, Bernard M. J. Uitdehaag, Lisa van Winsen, Chris H. Polman

Publikováno v: Multiple Sclerosis Journal, 16, 500-2
van Winsen, L M L, Polman, C H, Dijkstra, C D, Tilders, F J H & Uitdehaag, B M J 2010, ' Suppressive effect of glucocorticoids on TNF-alpha production is associated with their clinical effect in multiple sclerosis ', Multiple Sclerosis, vol. 16, no. 4, pp. 500-502 . https://doi.org/10.1177/1352458509359721
Multiple Sclerosis Journal, 16, 4, pp. 500-2
Multiple Sclerosis, 16(4), 500-502. SAGE Publications Ltd

Item does not contain fulltext A reduced sensitivity to glucocorticoids can affect the clinical effect of treatment with high-dose intravenous methylprednisolone in multiple sclerosis. We prospectively studied 27 multiple sclerosis patients who were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb1fbe1a5d95f793945cfcc85985482
http://hdl.handle.net/2066/89117

Sensitivity to glucocorticoids is decreased in relapsing remitting multiple sclerosis

Autor: Chris H. Polman, Lisa van Winsen, Timo K. van den Berg, Bernard M. J. Uitdehaag, Daan F R Muris, Christine D. Dijkstra

Publikováno v: Journal of clinical endocrinology and metabolism, 90(2), 734-740. The Endocrine Society
The Journal of clinical endocrinology and metabolism, 90(2), 734-40. The Endocrine Society
van Winsen, L M L, Muris, D F R, Polman, C H, Dijkstra, C D, van den Berg, T K & Uitdehaag, B M J 2005, ' Sensitivity to glucocorticoids is decreased in relapsing remitting multiple sclerosis ', The Journal of clinical endocrinology and metabolism, vol. 90, no. 2, pp. 734-40 . https://doi.org/10.1210/jc.2004-0306

Endogenous glucocorticoids (GC), which are under control of the hypothalamic-pituitary-adrenal axis, play an important role in controlling chronic inflammatory demyelinating diseases, like multiple sclerosis (MS). Increased hypothalamic-pituitary-adr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b6ada9884791dcd6b631b36b032429
https://pubmed.ncbi.nlm.nih.gov/15546910

CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis

Autor: Tineke van Veen, Bernard M. J. Uitdehaag, J. Bart A. Crusius, Frederik Barkhof, Lisa van Winsen, Bing Xia, Chris H. Polman, A. Salvador Peña

Publikováno v: van Veen, T, Crusius, J B A, van Winsen, L, Xia, B, Barkhof, F, Pena, A S, Polman, C H & Uitdehaag, B M J 2003, ' CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis. ', Journal of Neuroimmunology, vol. 140, no. 1-2, pp. 188-93 . https://doi.org/10.1016/S0165-5728(03)00184-X
Journal of Neuroimmunology, 140(1-2), 188-93. Elsevier

The balance between CD28 and CTLA-4 signalling is important for regulation of the immune response. We were interested whether a genetically mediated disturbance of this balance could be related to susceptibility or severity of multiple sclerosis (MS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b90045688927ce3bd481dfc340a3594
https://research.vumc.nl/en/publications/793cfa54-6e91-4b28-a906-841b48b21d85