Výsledky vyhledávání - "Lisa Woodworth"

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

Publikováno v: Nature Neuroscience
Nature Neuroscience (2021)
Nature neuroscience 24(3), 355-367 (2021). doi:10.1038/s41593-020-00780-7

Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebcdb3392cdcf8bf64de6471ae63665

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CSF1R signaling is a regulator of pathogenesis in progressive MS

Autor: Matija Zelic, Jose Sancho, Yi Li, Nellwyn Hagan, Oleg Butovsky, John L. Kane, Lisa Woodworth, Andrew Scholte, Charlotte Madore, Michael Kothe, Barbara Gisevius, Dimitry Ofengeim, Jacqueline Saleh, Jonathan Proto, Deepak Grover, Maria Fitzgerald, Aiden Haghikia, Jinyu Liu, Amy Mahan

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 10, Pp 1-25 (2020)

Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc9ca138cd4d331e3ff620100313d25
http://europepmc.org/articles/PMC7584629

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RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

Autor: Dimitry Ofengeim, Egil Lien, Alexei Degterev, Pontus Orning, Yi Ren, Matija Zelic, Aislinn Keane, Lilu Guo, Lisa Woodworth, Ross C. Gruber, Michael LaMorte, Tai-he Xia, Pequita Loring, Boyao Zhang, Fabrizio Pontarelli, Amy Mahan, Cheng Zhu, Timothy R. Hammond

Publikováno v: e1-e7
Cell reports

Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory signaling and is increased in multiple sclerosis (MS) brain samples. Here, we investigate the role of glial RIPK1 kinase activity in mediating MS pathogenesis. We demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c256dfb9fcdaf94d307edafe0a6d7c0
https://pubmed.ncbi.nlm.nih.gov/33979622

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Gene Transfer to the CNS Is Efficacious in Immune-primed Mice Harboring Physiologically Relevant Titers of Anti-AAV Antibodies

Autor: S. Pablo Sardi, Marco A. Passini, Jie Bu, Lisa Woodworth, Gregory D Hurlbut, James Dodge, Lamya S. Shihabuddin, Christopher M. Treleaven, Thomas J. Tamsett, Jonathan A. Fidler, Seng H. Cheng

Publikováno v: Molecular Therapy. 20(9):1713-1723

Central nervous system (CNS)-directed gene therapy with recombinant adeno-associated virus (AAV) vectors has been used effectively to slow disease course in mouse models of several neurodegenerative diseases. However, these vectors were typically tes

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Preexisting Immunity and Low Expression in Primates Highlight Translational Challenges for Liver-directed AAV8-mediated Gene Therapy

Autor: Scott D. Bercury, John Marshall, Nilesh Pande, Lisa Woodworth, Seng H. Cheng, Ronald K. Scheule, Jennifer B. Nietupski, Mark Bree, David W. Souza, Robin J. Ziegler, Michael Lukason, Elizabeth Meyers, Joseph W. Foley, Gregory D Hurlbut

Publikováno v: Molecular Therapy. 18:1983-1994

Liver-directed gene therapy with adeno-associated virus (AAV) vectors effectively treats mouse models of lysosomal storage diseases (LSDs). We asked whether these results were likely to translate to patients. To understand to what extent preexisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4233401d6c87256f502e812872df1557
https://doi.org/10.1038/mt.2010.175

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Cytotoxic T Lymphocyte Responses to Transgene Product, Not Adeno-Associated Viral Capsid Protein, Limit Transgene Expression in Mice

Autor: William M. Siders, Johanne Kaplan, Abraham Scaria, Michael Lukason, Jacqueline Shields, Sam Wadsworth, Lisa Woodworth

Publikováno v: Human Gene Therapy. 20:11-20

The use of adeno-associated viral (AAV) vectors for gene replacement therapy is currently being explored in several clinical indications. However, reports have suggested that input capsid proteins from AAV-2 vector particles may result in the stimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450dec2f6ef86e261d3594c125a2d782
https://doi.org/10.1089/hum.2008.055

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Potentiation of Gene Transfer to the Mouse Lung by Complexes of Adenovirus Vector and Polycations Improves Therapeutic Potential

Autor: Sarah E. Pennington, Richard J. Gregory, Samuel C. Wadsworth, John Marshall, Lisa Woodworth, Alan E. Smith, Judith A. St. George, Seng H. Cheng, Johanne Kaplan, A Fasbender

Publikováno v: Human Gene Therapy. 9:1469-1479

Recombinant adenovirus (Ad) vectors are being considered for in vivo delivery of various therapeutic genes. One limiting factor in the development of Ad-based gene therapy is the low efficiency of gene transfer to target tissues such as vascular endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48892973f07bd0c6a522dcafddae3519
https://doi.org/10.1089/hum.1998.9.10-1469

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80. Pre-Existing Cytotoxic T-Lymphocyte (CTL) Responses to the AAV CAP Protein Do Not Interfere with AAV Transgene Expression in Mice

Autor: Abraham Scaria, William M. Siders, Lisa Woodworth, Jacqueline Shields, Johanne Kaplan, Michael Lukason, Sam Wadsworth

Publikováno v: Molecular Therapy. 13

The use of adeno-associated viral (AAV) vectors as a delivery method for gene replacement strategies is currently being explored in several clinical indications. AAV vectors do not express any viral proteins suggesting that they represent a less immu

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Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes

Autor: Alan E. Smith, Samuel C. Wadsworth, Abraham Scaria, Lisa Woodworth, Donna Armentano, Johanne Kaplan, Richard J. Gregory, Sarah E. Pennington

Publikováno v: Journal of virology. 73(5)

Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596777c18063f659ee753e64ac949c99
https://pubmed.ncbi.nlm.nih.gov/10196353

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