Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Lisa Won"'
IFNγ-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Migraine is a common headache disorder characterized by unilateral, intense headaches. In migraine with aura, the painful headache is preceded by focal neurological symptoms that can be visual, sensory, or motor in nature. Spreading depression (the m
Externí odkaz:
https://doaj.org/article/f7437040a88c4222bca1055a5a95c1c8
Autor:
Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 67-76 (2015)
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of l-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergi
Externí odkaz:
https://doaj.org/article/250b8769fd3246af8e7899fcd8c6a4bb
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 1, Pp 11-23 (2007)
l-DOPA-induced dyskinesia (LID) is one of the main limitations of long term l-DOPA use in Parkinson’s disease (PD) patients. We show that chronic l-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal defi
Externí odkaz:
https://doaj.org/article/7fb32ebfd1e442dd9204daf40d090e09
Publikováno v:
Journal of Cellular Immunology. 3
Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7defd7b774534bb67d74231d69e3ba8
https://doi.org/10.33696/immunology.3.102
https://doi.org/10.33696/immunology.3.102
Publikováno v:
Journal of cellular immunology
Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96773014f043098a0a14306a67b6e141
https://pubmed.ncbi.nlm.nih.gov/34337600
https://pubmed.ncbi.nlm.nih.gov/34337600
IFNγ-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Frontiers in Neuroscience
Migraine is a common headache disorder characterized by unilateral, intense headaches. In migraine with aura, the painful headache is preceded by focal neurological symptoms that can be visual, sensory, or motor in nature. Spreading depression (the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c82422ac7b76e3d327d2d2ab5f5e36
https://doi.org/10.3389/fnins.2019.00942
https://doi.org/10.3389/fnins.2019.00942
Autor:
Richard P. Kraig, Lisa Won
Publikováno v:
Brain Research. 1732:146673
Migraineurs can show brain hyperexcitability and oxidative stress that may promote headache. Since hyperexcitability can enhance oxidative stress which promotes hyperexcitability, ending this feed-back loop may reduce migraine. Neocortical spreading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a36d31fd4a6f717c73411fef15b1431
https://doi.org/10.1016/j.brainres.2020.146673
https://doi.org/10.1016/j.brainres.2020.146673
Autor:
Jessica C. Graham, Lisa Wong, Adeyemi O. Adedeji, Aija Kusi, Becky Lee, Donna Lee, Noel Dybdal
Publikováno v:
Animals, Vol 13, Iss 24, p 3863 (2023)
Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement
Externí odkaz:
https://doaj.org/article/209b4c4d48d4420bb934a00ca7c28cb0
Autor:
Lisa Won, Yunmin Ding, Un Jung Kang, Sean Austin O. Lim, Jonathan P. Britt, Daniel S. McGehee
Publikováno v:
Proceedings of the National Academy of Sciences. 108:840-845
Treatment of Parkinson disease (PD) with l -3,4-dihydroxyphenylalanine ( l -DOPA) dramatically relieves associated motor deficits, but l -DOPA–induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df1180158e72f418cea5bf12bf4c5af
https://doi.org/10.1073/pnas.1006511108
https://doi.org/10.1073/pnas.1006511108
Publikováno v:
Neuroscience Letters. 353:83-86
Lysates of X61, a striatal-derived cell line, and a partially purified preparation from the lysate (UF4) contain a factor(s) capable of increasing the dopamine content of a mesencephalic-derived dopaminergic cell line (MN9D) and of cultures containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6676a8f9e8ab834dcbce62c576ab30
https://doi.org/10.1016/j.neulet.2003.08.081
https://doi.org/10.1016/j.neulet.2003.08.081