Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Lisa Wiesmüller"'
Autor:
Mohamed Akmal Marzouk, Sara Greco, Florence Gbahou, Jenni Küblbeck, Nedjma Labani, Ralf Jockers, Ulrike Holzgrabe, Lisa Wiesmüller, Darius P. Zlotos
Publikováno v:
ACS Omega, Vol 9, Iss 48, Pp 47857-47871 (2024)
Externí odkaz:
https://doaj.org/article/26a46784b974474a9166cd69e73c3086
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-16 (2024)
Abstract Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and preventing tumor development. Over the years, p53 was found to exist in various isoforms, which are generated through alternative splicing, alternative initiat
Externí odkaz:
https://doaj.org/article/6c245dc1415848df9c32e4f5b265f9cc
Autor:
Juliane Sachsenweger, Rebecca Jansche, Tatjana Merk, Benedikt Heitmeir, Miriam Deniz, Ulrike Faust, Cristiana Roggia, Andreas Tzschach, Christopher Schroeder, Angelika Riess, Helmut Pospiech, Hellevi Peltoketo, Katri Pylkäs, Robert Winqvist, Lisa Wiesmüller
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-15 (2023)
Abstract It has been well-established that mutations in BRCA1 and BRCA2, compromising functions in DNA double-strand break repair (DSBR), confer hereditary breast and ovarian cancer risk. Importantly, mutations in these genes explain only a minor fra
Externí odkaz:
https://doaj.org/article/22359356d9db4cbc807bfe4a73796d52
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-14 (2021)
Abstract The recently discovered p53-dependent DNA damage tolerance (DDT) pathway relies on its biochemical activities in DNA-binding, oligomerization, as well as complex formation with the translesion synthesis (TLS) polymerase iota (POLι). These p
Externí odkaz:
https://doaj.org/article/c2ffa96a58b34f0bb8aa8a21cb59c600
Autor:
Julia Eberle, Rahel Stefanie Wiehe, Boris Gole, Liska Jule Mattis, Anja Palmer, Ludger Ständker, Wolf-Georg Forssmann, Jan Münch, J. Christof M. Gebhardt, Lisa Wiesmüller
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Rearrangements in the Mixed Lineage Leukemia breakpoint cluster region (MLLbcr) are frequently involved in therapy-induced leukemia, a severe side effect of anti-cancer therapies. Previous work unraveled Endonuclease G as the critical nuclease causin
Externí odkaz:
https://doaj.org/article/690d8419243e4e368712118f4286895d
Autor:
Shahar Biechonski, Leonid Olender, Adi Zipin-Roitman, Muhammad Yassin, Nasma Aqaqe, Victoria Marcu-Malina, Melanie Rall-Scharpf, Magan Trottier, M. Stephen Meyn, Lisa Wiesmüller, Katia Beider, Yael Raz, Dan Grisaru, Arnon Nagler, Michael Milyavsky
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis. Although HSPCs are widely considered a target of ionizing radiation (I
Externí odkaz:
https://doaj.org/article/9313fac1c8ce4adb8917c5a6468462c9
Autor:
Salih Demir, Elena Boldrin, Qian Sun, Stephanie Hampp, Eugen Tausch, Cornelia Eckert, Martin Ebinger, Rupert Handgretinger, Geertruy te Kronnie, Lisa Wiesmüller, Stephan Stilgenbauer, Galina Selivanova, Klaus-Michael Debatin, Lüder Hinrich Meyer
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DN
Externí odkaz:
https://doaj.org/article/bc5b47cc9d5e44d6ac89de5a2c7859c3
Autor:
Katharina Keupp, Stephanie Hampp, Annette Hübbel, Monika Maringa, Sarah Kostezka, Kerstin Rhiem, Anke Waha, Barbara Wappenschmidt, Roser Pujol, Jordi Surrallés, Rita K. Schmutzler, Lisa Wiesmüller, Eric Hahnen
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 9, Pp n/a-n/a (2019)
Abstract Background Biallelic BRCA1 mutations are regarded either embryonically lethal or to cause Fanconi anemia (FA), a genomic instability syndrome characterized by bone marrow failure, developmental abnormalities, and cancer predisposition. We re
Externí odkaz:
https://doaj.org/article/6072626b1bad465e92c630f0e2e02109
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 981 (2021)
The genetic principle of synthetic lethality has most successfully been exploited in therapies engaging Poly-ADP-ribose-polymerase (PARP) inhibitors to treat patients with homologous recombination (HR)-defective tumors. In this work, we went a step f
Externí odkaz:
https://doaj.org/article/f6654e3bc0d74ca0aa90b5c329c8cb28
Autor:
Sabrina F. Mansilla, Agostina P. Bertolin, Sofía Venerus Arbilla, Bryan A. Castaño, Tiya Jahjah, Jenny K. Singh, Sebastián O. Siri, María Victoria Castro, María Belén de la Vega, Annabel Quinet, Lisa Wiesmüller, Vanesa Gottifredi
Publikováno v:
Science Advances. 9
Recent studies have described a DNA damage tolerance pathway choice that involves a competition between PrimPol-mediated repriming and fork reversal. Screening different translesion DNA synthesis (TLS) polymerases by the use of tools for their deplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e5f9abbb66566b7997ccd0ff25c529
https://doi.org/10.1126/sciadv.ade7997
https://doi.org/10.1126/sciadv.ade7997