Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lisa Welzel"'
Autor:
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105227- (2021)
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for develo
Externí odkaz:
https://doaj.org/article/ebf73ea039fa4ed9bcb04004def2080c
Autor:
Christine Henke, Kathrin Töllner, R. Maarten van Dijk, Nina Miljanovic, Thekla Cordes, Friederike Twele, Sonja Bröer, Vanessa Ziesak, Marco Rohde, Stefanie M. Hauck, Charlotte Vogel, Lisa Welzel, Tina Schumann, Diana M. Willmes, Anica Kurzbach, Nermeen N. El-Agroudy, Stefan R. Bornstein, Susanne A. Schneider, Jens Jordan, Heidrun Potschka, Christian M. Metallo, Rüdiger Köhling, Andreas L. Birkenfeld, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 105018- (2020)
In addition to tissues such as liver, the plasma membrane sodium-dependent citrate transporter, NaCT (SLC13A5), is highly expressed in brain neurons, but its function is not understood. Loss-of-function mutations in the human SLC13A5 gene have been a
Externí odkaz:
https://doaj.org/article/df9b3f253ba04e89ae8d4ee2953dca43
Autor:
Alina Schidlitzki, Pablo Bascuñana, Prashant K. Srivastava, Lisa Welzel, Friederike Twele, Kathrin Töllner, Christopher Käufer, Birthe Gericke, Rahel Feleke, Martin Meier, Andras Polyak, Tobias L. Ross, Ingo Gerhauser, Jens P. Bankstahl, Michael R. Johnson, Marion Bankstahl, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in sili
Externí odkaz:
https://doaj.org/article/87f6ca923e384f6d9e939b1b144f625c
Autor:
Kerstin Römermann, Marie Johne, Björn Gailus, Lisa Welzel, Kai Kaila, Hannah Naundorf, Wolfgang Löscher
Publikováno v:
Epilepsia. 62:2826-2844
Objective: Birth asphyxia is a major cause of hypoxic-ischemic encephalopathy (HIE) in neonates and often associated with mortality, neonatal seizures, brain damage, and later life motor, cognitive, and behavioral impairments and epilepsy. Preclinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cece3a99803aeb9f2a06511d1d9ca5c
https://doi.org/10.1111/epi.17050
https://doi.org/10.1111/epi.17050
Autor:
Lisa Welzel, Pavel Klein, Wolfgang Löscher, Alina Schidlitzki, Kathrin Töllner, Friederike Twele
Publikováno v:
Epilepsy Research. 151:48-66
Network-based approaches in drug discovery comprise both development of novel drugs interacting with multiple targets and repositioning of drugs with known targets to form novel drug combinations that interact with cellular or molecular networks whos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba07d5af62d1042e99bf0b1849753f73
https://doi.org/10.1016/j.eplepsyres.2019.02.010
https://doi.org/10.1016/j.eplepsyres.2019.02.010
Autor:
David H. Bergin, Marie Johne, Pavel Klein, Friederike Twele, Alina Schidlitzki, Wolfgang Löscher, Lisa Welzel
Publikováno v:
Neurobiology of Disease, Vol 149, Iss, Pp 105227-(2021)
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaf7891f5e8f6fd3910fc19f4bd1868
https://pubmed.ncbi.nlm.nih.gov/33347976
https://pubmed.ncbi.nlm.nih.gov/33347976
Autor:
András Polyák, Christopher Käufer, Marion Bankstahl, Jens P. Bankstahl, Martin Meier, Pablo Bascuñana, Tobias L. Ross, Ingo Gerhauser, Kathrin Töllner, Marvin Johnson, Lisa Welzel, Friederike Twele, Wolfgang Löscher, Alina Schidlitzki, Birthe Gericke, Prashant K. Srivastava, Rahel Feleke
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in sili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96176afa80236ce8cc583503f7fde1c
http://hdl.handle.net/10044/1/76196
http://hdl.handle.net/10044/1/76196
Publikováno v:
EpilepsiaREFERENCES. 61(1)
OBJECTIVE Intracranial (intrahippocampal or intra-amygdala) administration of kainate in rodents leads to spatially restricted brain injury and development of focal epilepsy with characteristics that resemble mesial temporal lobe epilepsy. Such roden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8ffcd0e8228e22c0a4545d61d12f4e
https://pubmed.ncbi.nlm.nih.gov/31828786
https://pubmed.ncbi.nlm.nih.gov/31828786
Autor:
Muneeb Anjum, Friederike Twele, Claudia Brandt, Edith Kaczmarek, Petra Hillmann, Wolfgang Löscher, Alina Schidlitzki, Lisa Welzel, Wiebke Theilmann, Birthe Gericke
Publikováno v:
Neuropharmacology. 162:107817
Dysregulation of the PI3K/Akt/mTOR pathway has been implicated in several brain disorders, including epilepsy. Rapamycin and similar compounds inhibit mTOR. complex 1 and have been reported to decrease seizures, delay seizure development, or prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe45ed7e92d743ddcba3e17f8d3e8aa
https://doi.org/10.1016/j.neuropharm.2019.107817
https://doi.org/10.1016/j.neuropharm.2019.107817