Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Lisa V Goodrich"'
Autor:
Bridget M Curran, Kelsey R Nickerson, Andrea R Yung, Lisa V Goodrich, Alexander Jaworski, Marc Tessier-Lavigne, Le Ma
Publikováno v:
eLife, Vol 13 (2024)
The dorsal funiculus in the spinal cord relays somatosensory information to the brain. It is made of T-shaped bifurcation of dorsal root ganglion (DRG) sensory axons. Our previous study has shown that Slit signaling is required for proper guidance du
Externí odkaz:
https://doaj.org/article/4e5b23a3d32f43e89994292e30eaf048
Autor:
Michelle M Frank, Austen A Sitko, Kirupa Suthakar, Lester Torres Cadenas, Mackenzie Hunt, Mary Caroline Yuk, Catherine JC Weisz, Lisa V Goodrich
Publikováno v:
eLife, Vol 12 (2023)
Brainstem olivocochlear neurons (OCNs) modulate the earliest stages of auditory processing through feedback projections to the cochlea and have been shown to influence hearing and protect the ear from sound-induced damage. Here, we used single-nucleu
Externí odkaz:
https://doaj.org/article/2ef0530c5f474276ad9da559b2220486
Autor:
Holly Hardy, James GD Prendergast, Aara Patel, Sunit Dutta, Violeta Trejo-Reveles, Hannah Kroeger, Andrea R Yung, Lisa V Goodrich, Brian Brooks, Jane C Sowden, Joe Rainger
Publikováno v:
eLife, Vol 8 (2019)
Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical det
Externí odkaz:
https://doaj.org/article/954b152a5b0d453aa0310ee5b9f00758
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004823 (2014)
Tonotopy is a fundamental organizational feature of the auditory system. Sounds are encoded by the spatial and temporal patterns of electrical activity in spiral ganglion neurons (SGNs) and are transmitted via tonotopically ordered processes from the
Externí odkaz:
https://doaj.org/article/2b6c766867114ffaa29b14709a99a31b
Autor:
Andrea Yung, Lisa V Goodrich
Publikováno v:
eLife, Vol 2 (2013)
When the axons that carry signals to muscles are growing, they rely on help from Frizzled3—a protein that is known to perform a number of other important functions in cells—to reach their final destination.
Externí odkaz:
https://doaj.org/article/bd559f3a734f4a5b873a02cb036c5839
Autor:
Wei-Ming Yu, Jessica M Appler, Ye-Hyun Kim, Allison M Nishitani, Jeffrey R Holt, Lisa V Goodrich
Publikováno v:
eLife, Vol 2 (2013)
Information flow through neural circuits is determined by the nature of the synapses linking the subtypes of neurons. How neurons acquire features distinct to each synapse remains unknown. We show that the transcription factor Mafb drives the formati
Externí odkaz:
https://doaj.org/article/f133127fccd145e8ae3c48a4be418387
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003824 (2013)
Lrig proteins are conserved transmembrane proteins that modulate a variety of signaling pathways from worm to humans. In mammals, there are three family members - Lrig1, Lrig2, and Lrig3--that are defined by closely related extracellular domains with
Externí odkaz:
https://doaj.org/article/1e5962314c514c15bec30bdffbec7749
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29495 (2012)
The vestibular apparatus of the vertebrate inner ear uses three fluid-filled semicircular canals to sense angular acceleration of the head. Malformation of these canals disrupts the sense of balance and frequently causes circling behavior in mice. Th
Externí odkaz:
https://doaj.org/article/3563563f4033427c8ef32f89d9245b03
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31988 (2012)
Experiments utilizing the Looptail mutant mouse, which harbors a missense mutation in the vangl2 gene, have been essential for studies of planar polarity and linking the function of the core planar cell polarity proteins to other developmental signal
Externí odkaz:
https://doaj.org/article/5d165f89a6704151b428ab999398490a
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e8981 (2010)
The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanis
Externí odkaz:
https://doaj.org/article/865543bdd5bf4817b2040b293e4c4201