Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Lisa Tuel-Ahlgren"'
Autor:
Lisa Tuel-Ahlgren, Chen Mao, Fatih M. Uckun, Elise Sudbeck, Taracad K. Venkatachalam, Rakesh Vig
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:3225-3233
Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been designed based on the structure of the NNI bindi
Autor:
Rakesh Vig, Elise A. Sudbeck, Fatih M. Uckun, Taracad K. Venkatachalam, Lisa Tuel-Ahlgren, Chen Mao
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1789-1797
A series of novel phenethylthiazolylthiourea (PETT) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of HIV reverse transcriptase (RT) have been designed based on the structure of the NNI binding pocket. The structure-based design
Autor:
Lisa Tuel-Ahlgren, Chen Mao, Taracad K. Venkatachalam, Elise A. Sudbeck, Fatih M. Uckun, Rakesh Vig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1461-1466
Novel dihydroalkoxybenzyloxopyrimidine (S-DABO) derivatives targeting the non-nucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been synthesized using a novel computer model for the NNI bind
Autor:
Tomohiro Kurosaki, Sandeep Mahajan, David Pond, Fatih M. Uckun, Alexei Vassilev, Alice Chu, Dong Tuong, Daiva Kristupaitis, Ilker Dibirdik, Lisa Tuel-Ahlgren, Richard Luben
Publikováno v:
Journal of Biological Chemistry. 273:12397-12401
Here we present evidence that exposure of DT40 lymphoma B-cells to low energy electromagnetic fields (EMF) results in activation of phospholipase C-gamma 2 (PLC-gamma2), leading to increased inositol phospholipid turnover. PLC-gamma2 activation in EM
Autor:
Fatih M. Uckun, R. Bruce Rowley, Dorothea E. Myers, Lisa Tuel-Ahlgren, Kevin G. Waddick, Joseph B. Bolen, Anne L. Burkhardt, Xiao Jun, Jizhong Jin
Publikováno v:
Journal of Biological Chemistry. 271:6389-6397
Exposure of human B-cell precursors (BCP) to ionizing radiation results in cell cycle arrest at the G2-M checkpoint as a result of inhibitory tyrosine phosphorylation of p34cdc2 . Here, we show that ionizing radiation promotes physical interactions b
Autor:
Lisa Tuel-Ahlgren, Lisa M. Chelstrom, Dorothea E. Myers, Roland Gunther, John Simon, Fatih M. Uckun
Publikováno v:
Blood. 85:2537-2545
The study of central nervous system (CNS) leukemia has been hampered by the lack of a suitable animal model. We report that severe combined immunodeficiency (SCID) mice invariably develop rapidly progressive fatal CNS leukemia within 3 weeks after in
Autor:
Andrew J. Carroll, Lisa M. Chelstrom, Lisa Tuel-Ahlgren, John Simon, Fatih M. Uckun, William M. Crist, Megan Ryan, Roland Gunther, James R. Downing
Publikováno v:
Blood. 84:859-865
Mice with severe combined immunodeficiency (SCID) were injected intravenously with primary bone marrow blasts from 12 children with newly diagnosed t(4;11)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from eight patients caused overt dissemina
Autor:
A. L. Burkhardt, F. M. Uckun, Joseph B. Bolen, Lisa Tuel-Ahlgren, Xiao Jun, B. Stealey, Lisa J. Jarvis, Ilker Dibirdik, Dorothea E. Myers
Publikováno v:
Journal of Biological Chemistry. 268:21172-21184
We present evidence that the CD19 receptor is functionally operative and transmits pleiotropic signals throughout the pro-B, pre-pre-B, pre-B, early B, and mature B cell stages of human B-cell ontogeny. The signaling ability of CD19 does not depend o
Autor:
Lisa Tuel-Ahlgren, Rakesh Vig, Fatih M. Uckun, Elise A. Sudbeck, Chen Mao, Taracad K. Venkatachalam
Publikováno v:
ChemInform. 29
Novel dihydroalkoxybenzyloxopyrimidine (S-DABO) derivatives targeting the non-nucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been synthesized using a novel computer model for the NNI bind
Autor:
Lisa Tuel-Ahlgren, Taracad K. Venkatachalam, Chen Mao, Fatih M. Uckun, Danielle Maher, Sharon Pendergrass, Dan Zhu
Publikováno v:
ChemInform. 30
We have replaced the pyridyl ring of trovirdine with an alicyclic cyclohexenyl, adamantyl or cis -myrtanyl ring. Only the cyclohexenyl-containing thiourea compound N-[2-(1-cyclohexenyl)ethyl]-N′-[2-(5-bromopyridyl)]-thiourea (HI-346) (as well as it