The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

Autor: G. Tuba Barut, Nico Joel Halwe, Adriano Taddeo, Jenna N. Kelly, Jacob Schön, Nadine Ebert, Lorenz Ulrich, Christelle Devisme, Silvio Steiner, Bettina Salome Trüeb, Bernd Hoffmann, Inês Berenguer Veiga, Nathan Georges François Leborgne, Etori Aguiar Moreira, Angele Breithaupt, Claudia Wylezich, Dirk Höper, Kerstin Wernike, Aurélie Godel, Lisa Thomann, Vera Flück, Hanspeter Stalder, Melanie Brügger, Blandina I. Oliveira Esteves, Beatrice Zumkehr, Guillaume Beilleau, Annika Kratzel, Kimberly Schmied, Sarah Ochsenbein, Reto M. Lang, Manon Wider, Carlos Machahua, Patrick Dorn, Thomas M. Marti, Manuela Funke-Chambour, Andri Rauch, Marek Widera, Sandra Ciesek, Ronald Dijkman, Donata Hoffmann, Marco P. Alves, Charaf Benarafa, Martin Beer, Volker Thiel

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

A comprehensive characterisation of Omicron-BA.1 and VOC Delta in numerous in vitro and in vivo models uncovers the factors that led to its global dominance.

Externí odkaz: https://doaj.org/article/d61f64a2bd024554b35cf6a993be8d5f

SARS-CoV-2 spike D614G change enhances replication and transmission

Autor: Li Wang, Berta Pozzi, Jenna N. Kelly, Malania M. Wilson, Fabien Labroussaa, Nannan Jiang, Charaf Benarafa, Jasmine Portmann, John R. Barnes, Matthew W. Keller, Volker Thiel, Bin Zhou, Bernd Hoffmann, Joerg Jores, Lorenz Ulrich, Silvio Steiner, Jacqueline King, Tran Thi Nhu Thao, Ronald Dijkman, Xiaoyu Fan, Nico Joel Halwe, David E. Wentworth, Hanspeter Stalder, Dan Cui, Bettina Salome Trüeb, Jaber Hossain, Simone de Brot, Donata Hoffmann, Thomas J. Stark, Martin Beer, Xudong Lin, Anne Pohlmann, Adriano Taddeo, Lisa Thomann, Nadine Ebert

Publikováno v: Nature

During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic1. However, whether the increasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c3a36f944abc8ad7f663dd36c0395
https://doi.org/10.1038/s41586-021-03361-1

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

Autor: Tuba Barut, Nico Joel Halwe, Adriano Taddeo, Jenna N. Kelly, Jacob Schön, Nadine Ebert, Lorenz Ulrich, Christelle Devisme, Silvio Steiner, Bettina Salome Trüeb, Bernd Hoffmann, Inês Berenguer Veiga, Nathan Georges François Leborgne, Etori Aguiar Moreira, Angele Breithaupt, Claudia Wylezich, Dirk Höper, Kerstin Wernike, Aurélie Godel, Lisa Thomann, Vera Flück, Hanspeter Stalder, Melanie Brügger, Blandina I. Oliveira Esteves, Beatrice Zumkehr, Guillaume Beilleau, Annika Kratzel, Kimberly Schmied, Sarah Ochsenbein, Reto M. Lang, Manon Wider, Carlos Machahua, Patrick Dorn, Thomas M. Marti, Manuela Funke-Chambour, Andri Rauch, Marek Widera, Sandra Ciesek, Ronald Dijkman, Donata Hoffmann, Marco P. Alves, Charaf Benarafa, Martin Beer, Volker Thiel

Publikováno v: Barut, G Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype. Nature Communications, 13(1), p. 5929. Springer Nature 10.1038/s41467-022-33632-y

Variant of concern (VOC) Omicron-BA1 has achieved global predominance in early 2022. Therefore, surveillance and comprehensive characterization of Omicron-BA.1 in advanced primary cell culture systems and multiple animal models is urgently needed. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e737ae0e300cce41859f337f3536dff3
https://pubmed.ncbi.nlm.nih.gov/36207334

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Autor: Lorenz Ulrich, Nico Joel Halwe, Adriano Taddeo, Nadine Ebert, Jacob Schön, Christelle Devisme, Bettina Salome Trüeb, Bernd Hoffmann, Manon Wider, Xiaoyu Fan, Meriem Bekliz, Manel Essaidi-Laziosi, Marie Luisa Schmidt, Daniela Niemeyer, Victor Max Corman, Anna Kraft, Aurélie Godel, Laura Laloli, Jenna N. Kelly, Brenda M. Calderon, Angele Breithaupt, Claudia Wylezich, Inês Berenguer Veiga, Mitra Gultom, Sarah Osman, Bin Zhou, Kenneth Adea, Benjamin Meyer, Christiane S. Eberhardt, Lisa Thomann, Monika Gsell, Fabien Labroussaa, Jörg Jores, Artur Summerfield, Christian Drosten, Isabella Anne Eckerle, David E. Wentworth, Ronald Dijkman, Donata Hoffmann, Volker Thiel, Martin Beer, Charaf Benarafa

Publikováno v: Nature
Ulrich, Lorenz; Halwe, Nico Joel; Taddeo, Adriano; Ebert, Nadine; Schön, Jacob; Devisme, Christelle; Trüeb, Bettina Salome; Hoffmann, Bernd; Wider, Manon; Fan, Xiaoyu; Bekliz, Meriem; Essaidi-Laziosi, Manel; Schmidt, Marie Luisa; Niemeyer, Daniela; Corman, Victor Max; Kraft, Anna; Godel, Aurélie; Laloli, Laura; Kelly, Jenna N; Calderon, Brenda M; ... (2022). Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta. Nature, 602(7896), pp. 307-313. Springer Nature 10.1038/s41586-021-04342-0

Emerging variants of concern (VOCs) are driving the COVID-19 pandemic1,2. Experimental assessments of replication and transmission of major VOCs and progenitors are needed to understand the mechanisms of replication and transmission of VOCs3. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72468d93d7b03eae09f65818ba78d565
https://pubmed.ncbi.nlm.nih.gov/34937050

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

Autor: Kenneth C McCullough, Isabelle Bassi, Panagiota Milona, Rolf Suter, Lisa Thomann-Harwood, Pavlos Englezou, Thomas Démoulins, Nicolas Ruggli

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)

Self-amplifying replicon RNA (RepRNA) possesses high potential for increasing antigen load within dendritic cells (DCs). The major aim of the present work was to define how RepRNA delivered by biodegradable, chitosan-based nanoparticulate delivery ve

Externí odkaz: https://doaj.org/article/5a224979cb0c41f395b0bcaf8cec7b56