Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lisa Starick"'
Autor:
Mohindar M. Karunakaran, Hariharan Subramanian, Yiming Jin, Fiyaz Mohammed, Brigitte Kimmel, Claudia Juraske, Lisa Starick, Anna Nöhren, Nora Länder, Carrie R. Willcox, Rohit Singh, Wolfgang W. Schamel, Viacheslav O. Nikolaev, Volker Kunzmann, Andrew J. Wiemer, Benjamin E. Willcox, Thomas Herrmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg
Externí odkaz:
https://doaj.org/article/f44499b1682d4024855a409410410b01
Autor:
Alina Suzann Fichtner, Mohindar Murugesh Karunakaran, Lisa Starick, Richard W. Truman, Thomas Herrmann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
1–5% of human blood T cells are Vγ9Vδ2 T cells whose T cell receptor (TCR) contain a TRGV9/TRGJP rearrangement and a TRDV2 comprising Vδ2-chain. They respond to phosphoantigens (PAgs) like isopentenyl pyrophosphate or (E)-4-hydroxy-3-methyl-but-
Externí odkaz:
https://doaj.org/article/828bffdac1164b29ad2935df435999c4
Autor:
Daniel Paletta, Alina Suzann Fichtner, Lisa Starick, Steven A Porcelli, Paul B Savage, Thomas Herrmann
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143449 (2015)
CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also
Externí odkaz:
https://doaj.org/article/91d18be1127f401082f4ced557b38707
Autor:
Elisa Monzon-Casanova, Birte Steiniger, Stefanie Schweigle, Holger Clemen, Daniela Zdzieblo, Lisa Starick, Ingrid Müller, Chyung-Ru Wang, Sara Rhost, Susanna Cardell, Elwira Pyz, Thomas Herrmann
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological condit
Externí odkaz:
https://doaj.org/article/edfd5180012744dd853e8c5794e12b17
Autor:
Mohindar Murugesh Karunakaran, Hariharan Subramanian, Yiming Jin, Fiyaz Mohammed, Brigitte Kimmel, Claudia Juraske, Lisa Starick, Anna Nöhren, Nora Länder, Carrie R. Willcox, Rohit Singh, Wolfgang W. Schamel, Viacheslav O. Nikolaev, Volker Kunzmann, Andrew J. Wiemer, Benjamin E. Willcox, Thomas Herrmann
Butyrophilin (BTN)-3A and BTN2A1 molecules control TCR-mediated activation of human Vγ9Vδ2 T-cells triggered by phosphoantigens (PAg) from microbes and tumors, but the molecular rules governing antigen sensing are unknown. Here we establish three m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bda15829a12b35dce98f02acc1f458
https://doi.org/10.21203/rs.3.rs-2583246/v1
https://doi.org/10.21203/rs.3.rs-2583246/v1
Autor:
Thomas Herrmann, Siyi Gu, Alina Suzann Fichtner, Lisa Starick, Anna Nöhren, Erin J. Adams, Mohindar Murugesh Karunakaran, Thomas W. Göbel, Christopher T. Boughter, Marta T. Borowska
Publikováno v:
Proceedings of the National Academy of Sciences. 117:6697-6707
Vγ9Vδ2 T cells are a major γδ T cell population in the human blood expressing a characteristic Vγ9JP rearrangement paired with Vδ2. This cell subset is activated in a TCR-dependent and MHC-unrestricted fashion by so-called phosphoantigens (PAgs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33eec99324881e3ec7160455fe1e2c22
https://doi.org/10.1073/pnas.1909474117
https://doi.org/10.1073/pnas.1909474117
Autor:
Alina S, Fichtner, Mohindar M, Karunakaran, Siyi, Gu, Christopher T, Boughter, Marta T, Borowska, Lisa, Starick, Anna, Nöhren, Thomas W, Göbel, Erin J, Adams, Thomas, Herrmann
Publikováno v:
Proc Natl Acad Sci U S A
Vγ9Vδ2 T cells are a major γδ T cell population in the human blood expressing a characteristic Vγ9JP rearrangement paired with Vδ2. This cell subset is activated in a TCR-dependent and MHC-unrestricted fashion by so-called phosphoantigens (PAgs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b648d6fd97d7f8ae89b8181e8225f93
https://pubmed.ncbi.nlm.nih.gov/32139608
https://pubmed.ncbi.nlm.nih.gov/32139608
Autor:
Lisa Starick, Mark Jeeves, Anna Nöhren, Carrie R. Willcox, Katie A Berwick, Paul A. Bates, Brigitte Kimmel, Alina Suzann Fichtner, Fiyaz Mohammed, Timothy J. Knowles, Vincent Pitard, Thomas Herrmann, Raphael A. G. Chaleil, Mahboob Salim, Daniel Paletta, Charlotte R Begley, Volker Kunzmann, Julie Déchanet-Merville, Mohindar Murugesh Karunakaran, Benjamin E. Willcox, Angela Noll, Lutz Walter
Publikováno v:
Immunity
Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory molecules,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39122f09271f7028d4c8862269c505d
http://europepmc.org/articles/PMC7083227
http://europepmc.org/articles/PMC7083227
Autor:
Lisa Starick, Alina Suzann Fichtner, Thomas D. Mueller, Niklas Beyersdorf, Elisa Monzón-Casanova, Thomas Herrmann, Daniel Paletta, Anne Maria Hahn
Publikováno v:
European Journal of Immunology. 45:2122-2133
TCRs of invariant NKT (iNKT) cells bind α-galactosylceramide (αGC) loaded CD1d in a highly conserved fashion and show a characteristic TCR gene usage: An "invariant" α chain with a canonical AV14/AJ18 rearrangement in mice (AV24/AJ18 in humans) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bba4f8cdfd734f0b253e4ae34c2e77
https://doi.org/10.1002/eji.201545534
https://doi.org/10.1002/eji.201545534
Autor:
Felipe Riano, Jianqiang Li, Mohindar Murugesh Karunakaran, Daniel Olive, Thomas Herrmann, Lisa Starick, Volker Kunzmann, Claus Jürgen Scholz, Sabine Amslinger
Publikováno v:
European Journal of Immunology. 44:2571-2576
Pyrophosphorylated metabolites of isoprenoid-biosynthesis (phosphoantigens, PAgs) activate Vγ9Vδ2 T cells during infections and trigger antitumor activity. This activation depends on expression of butyrophilin 3 A1 (BTN3A1) by antigen-presenting ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f2cb0b8bf05f940e2bb0266892c1ad
https://doi.org/10.1002/eji.201444712
https://doi.org/10.1002/eji.201444712