Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lisa Sevenich"'
Autor:
Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero‐Boix, Aylin Möckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H Plate, Yvonne Reiss, Franz Rödel, Lisa Sevenich
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-19 (2021)
Abstract The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Despite thei
Externí odkaz:
https://doaj.org/article/00137b811f904876a7198d982dadfa0c
Autor:
Michael Schulz, Lisa Sevenich
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages not only represent an integral part of innate immunity but also critically contribute to tissue and organ homeostasis. Moreover, disease progression is accompanied by macrophage accumulation in many cancer types and is often associated wi
Externí odkaz:
https://doaj.org/article/4ce014efe81c48a5a2038a1281493bcd
Autor:
Michael Schulz, Birgitta Michels, Katja Niesel, Stefan Stein, Henner Farin, Franz Rödel, Lisa Sevenich
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101178- (2020)
Summary: Brain-resident microglia and bone marrow-derived macrophages represent the most abundant non-cancerous cells in the brain tumor microenvironment with critical functions in disease progression and therapeutic response. To date little is known
Externí odkaz:
https://doaj.org/article/958c6ae9cac14733b76d5663f0219591
Autor:
Woon Hyung Chae, Katja Niesel, Michael Schulz, Florian Klemm, Johanna A. Joyce, Marcus Prümmer, Boris Brill, Judith Bergs, Franz Rödel, Ulrich Pilatus, Lisa Sevenich
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Brain metastases are the most common intracranial tumor in adults and are associated with poor patient prognosis and median survival of only a few months. Treatment options for brain metastasis patients remain limited and largely depend on surgical r
Externí odkaz:
https://doaj.org/article/054e472917e64dafb3ad947268479dc6
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cellular and non-cellular components of the tumor microenvironment (TME) are emerging as key regulators of primary tumor progression, organ-specific metastasis, and therapeutic response. In the era of TME-targeted- and immunotherapies, cancer-associa
Externí odkaz:
https://doaj.org/article/b8223e91629c43df8a4f0789415ad36e
Autor:
Lisa Sevenich
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The development of immunotherapies has revolutionized intervention strategies for a variety of primary cancers. Despite this promising progress, treatment options for primary brain cancer and brain metastasis remain limited and still largely depend o
Externí odkaz:
https://doaj.org/article/55fce874993649b29314d5f43bc2f2ca
Autor:
Lisa Sevenich
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Inflammation is a hallmark of different central nervous system (CNS) pathologies. It has been linked to neurodegenerative disorders as well as primary and metastatic brain tumors. Microglia, the brain-resident immune cells, are emerging as a central
Externí odkaz:
https://doaj.org/article/fcea1db2b03c4b5e8b5af6c25e3b2098
Autor:
Patrick N. Harter, Roy Thomas Daniel, Michael Schulz, Florian Klemm, Alexander Schaffer, Monika E. Hegi, Pia S. Zeiner, Roeltje R. Maas, Anna Salamero-Boix, Benelita T. Elie, Johanna A. Joyce, Robert L. Bowman, Katja Niesel, Lisa Sevenich, Marie Groth, Aylin Möckl, Jenny Zinke, Karl H. Plate, Tijna Alekseeva
Publikováno v:
Nature Cancer. 2:1086-1101
Tumor microenvironment-targeted therapies are emerging as promising treatment options for different cancer types. Tumor-associated macrophages and microglia (TAMs) represent an abundant nonmalignant cell type in brain metastases and have been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0012561b506fd8edf38617812bedda1f
https://doi.org/10.1038/s43018-021-00254-0
https://doi.org/10.1038/s43018-021-00254-0
Autor:
Nadja I. Lorenz, Benedikt Sauer, Pia S. Zeiner, Maja I. Strecker, Anna-Luisa Luger, Dorothea Schulte, Michel Mittelbronn, Tijna Alekseeva, Lisa Sevenich, Patrick N. Harter, Christian Münch, Joachim P. Steinbach, Michael W. Ronellenfitsch
AMP-activated protein kinase (AMPK) is a central cellular energy sensor that regulates metabolic activity. We hypothesised that in glioblastoma (GB), AMPK plays a pivotal role in balancing metabolism under conditions of the tumour microenvironment, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193b92bc1d62a935813004ce499f29aa
https://doi.org/10.1101/2022.03.25.485624
https://doi.org/10.1101/2022.03.25.485624
Autor:
Lila Bemmerlein, Ilker A. Deniz, Jana Karbanová, Angela Jacobi, Stephan Drukewitz, Theresa Link, Andy Göbel, Lisa Sevenich, Anna V. Taubenberger, Pauline Wimberger, Jan Dominik Kuhlmann, Denis Corbeil
Publikováno v:
Cancers; Volume 14; Issue 3; Pages: 603
Cancers, Vol 14, Iss 603, p 603 (2022)
Cancers, Vol 14, Iss 603, p 603 (2022)
Breast cancer is a heterogeneous disease and the mechanistic framework for differential osteotropism among intrinsic breast cancer subtypes is unknown. Hypothesizing that cell morphology could be an integrated readout for the functional state of a ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a4cabf6b1caf16b851a3a8c97cac2