Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lisa Seipold"'
Autor:
Stefan F. Lichtenthaler, Paul Saftig, Tobias B. Huber, Lukas Heintz, Lisa Seipold, Lisa Schebsdat, Maja T. Lindenmeyer, Renate Lüllmann-Rauch, Sebastian Wetzel, Stephanie Zielinski, Oliver Kretz, Catherine Meyer-Schwesinger, Marlies Sachs, Wiebke Sachs, Julia Reichelt, Thorsten Wiech, Stephan A. Müller
Publikováno v:
Journal of the American Society of Nephrology 32(6), 1389-1408 (2021). doi:10.1681/ASN.2020081213
J Am Soc Nephrol
J Am Soc Nephrol
Background Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd38702448fa14059c39567c6bc8975
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1869:119165
Besides its involvement in blood and bone physiology, the kidney's main function is to filter substances and thereby regulate the electrolyte composition of body fluids, acid-base balance and toxin removal. Depending on underlying conditions, the nep
Autor:
Edward T Davis, Michael G. Tomlinson, Lisa Seipold, Murat Keles, Natalie S. Poulter, Paul Saftig, Antonia Malinova, Stephan A. Mueller, Stefan F. Lichtenthaler, Alexandra L. Matthews, Bethany Cragoe, Hanh T.H. Nguyen, Stephen J. Briddon, Nicholas D. Holliday, Christos Pliotas, Chek Ziu Koo, Eric Rubinstein, Thomas A. McFarlane, Johanna Tüshaus, Michael C. Sykes, Justyna Szyroka, Eleanor Cull, Katie Willis, Haroon Ahmed, Alessandro Di Maio, Clara Apicella, Joelle Goulding, Peter J. Noy, Neale Harrison, Hung-En Hsia, Philip R. Morrison
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601
International audience; A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a “mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb363ab27157e6e501561ef205a029
https://hal.sorbonne-universite.fr/hal-03124330
https://hal.sorbonne-universite.fr/hal-03124330
Autor:
Hermann C. Altmeppen, Andreas Tholey, Julia Bär, Paul Saftig, Petr Kasparek, Lisa Seipold, Tomas Koudelka, Michaela Schweizer, Markus Glatzel, Marina Mikhaylova, Radislav Sedlacek
Publikováno v:
Cellular and Molecular Life Sciences. 75:3251-3267
A disintegrin and metalloproteinase 10 (ADAM10) plays a major role in the ectodomain shedding of important surface molecules with physiological and pathological relevance including the amyloid precursor protein (APP), the cellular prion protein, and
Autor:
Alexandra L. Matthews, Stefan F. Lichtenthaler, Edward T Davis, Hung-En Hsia, Antonia Malinova, Alessandro Di Maio, Michael G. Tomlinson, Justyna Szyroka, Paul Saftig, Michael C. Sykes, Neale Harrison, Katie Willis, Philip R. Morrison, Eleanor Cull, Chek Ziu Koo, Eric Rubinstein, Clara Apicella, Joelle Goulding, Stephen J. Briddon, Murat Keles, Lisa Seipold, Nicholas D. Holliday, Stephan A. Mueller, Bethany Cragoe, Natalie S. Poulter, Thomas A. McFarlane, Haroon Ahmed, Peter J. Noy, Johanna Tüshaus
A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a ‘molecular scissor’ that proteolytically cleaves the extracellular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6ba7b78aec233816b3516d596bd571
https://doi.org/10.1101/800557
https://doi.org/10.1101/800557
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(11 Pt)
Proteolytic cleavage represents a unique and irreversible posttranslational event regulating the function and half-life of many intracellular and extracellular proteins. The metalloproteinase ADAM10 has raised attention since it cleaves an increasing
Autor:
Paul Saftig, Lisa Seipold
Publikováno v:
Frontiers in Molecular Neuroscience. 10
Autor:
Paul Saftig, Lisa Seipold
Publikováno v:
Frontiers in Molecular Neuroscience
Tetraspanins are a family of ubiquitously expressed and conserved proteins, which are characterized by four transmembrane domains and the formation of a short and a large extracellular loop (LEL). Through interaction with other tetraspanins and trans
Autor:
Margherita Verani, Olaf Riess, Alberto Bresciani, Paola Martufi, Gerardo Biella, Paul Saftig, Elena Vezzoli, Francesca Talpo, Giulio Sancini, Ottavia Cecchetti, Paola Conforti, Andrea Falqui, Pia Rivetti di Val Cervo, Elisa Sogne, Lisa Seipold, Hoa Nguyen, Chiara Zuccato, Dario Besusso, Elena Cattaneo, Lara Petricca, Ilaria Caron, Andrea Caricasole, Elisa Battaglia
Publikováno v:
Journal of Clinical Investigation
A disintegrine and metalloproteinase 10 (ADAM10) is implicated in synaptic function through its interaction with postsynaptic receptors and adhesion molecules. Here, we report that levels of active ADAM10 are increased in Huntington's disease (HD) mo