Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Lisa Schimanski"'
Autor:
Eve Richardson, Sagida Bibi, Florence McLean, Lisa Schimanski, Pramila Rijal, Marie Ghraichy, Valentin von Niederhäusern, Johannes Trück, Elizabeth A. Clutterbuck, Daniel O’Connor, Kerstin Luhn, Alain Townsend, Bjoern Peters, Andrew J. Pollard, Charlotte M. Deane, Dominic F. Kelly
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Outbreaks of Ebolaviruses, such as Sudanvirus (SUDV) in Uganda in 2022, demonstrate that species other than the Zaire ebolavirus (EBOV), which is currently the sole virus represented in current licensed vaccines, remain a major threat to global healt
Externí odkaz:
https://doaj.org/article/245451aecafd4d5884059c3f71712a1a
Autor:
Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Cheng-Pin Chen, Shu-Hsing Cheng, Wen-Hsin Lee, Yu-Chi Chou, Alain R Townsend, Che Ma, Kuan-Ying A Huang
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012246 (2024)
Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals and elucidate the mechanism of action of broadly neutraliz
Externí odkaz:
https://doaj.org/article/6b2ca9b4f9fe4182828d175f566a58ee
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Autor:
Kuan-Ying A. Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
An antibody, IY-2A, identified from a panel of class-4 SARS-CoV-2-neutralizing antibodies isolated from convalescent and vaccinated individuals, targets and induces partial unfolding of a conserved epitope within the RBD. IY-2A retains activity again
Externí odkaz:
https://doaj.org/article/4fd4ed3b1b214dcab49cfc9d3f96eda6
Autor:
Nina Urke Ertesvåg, Julie Xiao, Fan Zhou, Sonja Ljostveit, Helene Sandnes, Sarah Lartey, Marianne Sævik, Lena Hansen, Anders Madsen, Kristin G. I. Mohn, Elisabeth Fjelltveit, Jan Stefan Olofsson, Tiong Kit Tan, Pramila Rijal, Lisa Schimanski, Siri Øyen, Karl Albert Brokstad, Susanna Dunachie, Anni Jämsén, William S. James, Adam C. Harding, Heli Harvala, Dung Nguyen, David Roberts, PHE Virology group, Maria Zambon, Oxford collaborative group, Alain Townsend, Bergen COVID-19 Research Group, Nina Langeland, Rebecca Jane Cox
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-11 (2022)
Ertesvåg, Xiao et al. describe a method to evaluate neutralising antibodies to SARS-CoV-2 infection or vaccination, including variants of concern. A second mRNA-vaccine dose results in a broader antibody repertoire in adults, although with reduced c
Externí odkaz:
https://doaj.org/article/cbafc65b10794cc39ff63dc23d9135f0
Autor:
Chandima Jeewandara, Suranga Fernando, Pradeep Darshana Pushpakumara, Shyrar Tanussiya Ramu, Achala Kamaladasa, Banuri Gunasekara, Inoka Sepali Aberathna, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathne, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jewantha Jayamali, Ayesha Wijesinghe, Madushika Dissanayake, Gayasha Somathilake, Michael Harvie, Saubhagya Danasekara, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Nihal Weerasooriya, Chinthaka Kekulandara, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract As the first dose of Gam-COVID-Vac, is currently used as a single dose vaccine in some countries, we investigated the immunogenicity of this at 4 weeks (327 naïve individuals). 88.7% seroconverted, with significantly lower seroconversion ra
Externí odkaz:
https://doaj.org/article/0407a97b8ebb47ed9707033b587b4732
Autor:
Donal T. Skelly, Adam C. Harding, Javier Gilbert-Jaramillo, Michael L. Knight, Stephanie Longet, Anthony Brown, Sandra Adele, Emily Adland, Helen Brown, Medawar Laboratory Team, Tom Tipton, Lizzie Stafford, Alexander J. Mentzer, Síle A. Johnson, Ali Amini, OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Pramila Rijal, PITCH (Protective Immunity T cells in Health Care Worker) Study Group, C-MORE/PHOSP-C Group, John Frater, Philip Goulder, Christopher P. Conlon, Katie Jeffery, Christina Dold, Andrew J. Pollard, Alex Sigal, Tulio de Oliveira, Alain R. Townsend, Paul Klenerman, Susanna J. Dunachie, Eleanor Barnes, Miles W. Carroll, William S. James
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.
Externí odkaz:
https://doaj.org/article/2028f3a39a5c4516bfd1ae04c2a4f499
Autor:
Chandima Jeewandara, Achala Kamaladasa, Pradeep Darshana Pushpakumara, Deshni Jayathilaka, Inoka Sepali Aberathna, Danasekara Rallage Saubhagya Rasikangani Danasekara, Dinuka Guruge, Thushali Ranasinghe, Shashika Dayarathna, Thilagaraj Pathmanathan, Gayasha Somathilake, Panambara Arachchige Deshan Madhusanka, Shyrar Tanussiya Ramu, Tibutius Thanesh Pramanayagam Jayadas, Heshan Kuruppu, Ayesha Wijesinghe, Herath Mudiyanselage Thashmi Nimasha, Dushantha Milroy, Achini Anuja Nandasena, Poththawela Kankanam Gamage Nilanka Sanjeewani, Ruwan Wijayamuni, Sudath Samaraweera, Lisa Schimanski, T. K. Tan, Tao Dong, Graham S. Ogg, Alain Townsend, Gathsaurie Neelika Malavige
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here the authors show in a large cohort of healthcare workers that one dose of the AZD1222 vaccine seroconverts 92.9% of vaccinees, irrespective of age and gender, and results in high antibody titers to wild-type SARS-CoV-2 but only low titers to the
Externí odkaz:
https://doaj.org/article/8ce8a0ccd45c48f3a81d8d158056219c
Autor:
Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract Background To determine the kinetics and persistence of immune responses following the Sinopharm/BBIBP‐CorV, we investigated immune responses in a cohort of Sri Lankan individuals. Methods SARS‐CoV‐2 specific total antibodies were meas
Externí odkaz:
https://doaj.org/article/fa7f9ac8fb0a40fb91a1d708c760475e
Autor:
Alain Townsend, Pramila Rijal, Julie Xiao, Tiong Kit Tan, Kuan-Ying A. Huang, Lisa Schimanski, Jiandong Huo, Nimesh Gupta, Rolle Rahikainen, Philippa C. Matthews, Derrick Crook, Sarah Hoosdally, Susanna Dunachie, Eleanor Barnes, Teresa Street, Christopher P. Conlon, John Frater, Carolina V. Arancibia-Cárcamo, Justine Rudkin, Nicole Stoesser, Fredrik Karpe, Matthew Neville, Rutger Ploeg, Marta Oliveira, David J. Roberts, Abigail A. Lamikanra, Hoi Pat Tsang, Abbie Bown, Richard Vipond, Alexander J. Mentzer, Julian C. Knight, Andrew J. Kwok, Gavin R. Screaton, Juthathip Mongkolsapaya, Wanwisa Dejnirattisai, Piyada Supasa, Paul Klenerman, Christina Dold, J. Kenneth Baillie, Shona C. Moore, Peter J. M. Openshaw, Malcolm G. Semple, Lance C. W. Turtle, Mark Ainsworth, Alice Allcock, Sally Beer, Sagida Bibi, Donal Skelly, Lizzy Stafford, Katie Jeffrey, Denise O’Donnell, Elizabeth Clutterbuck, Alexis Espinosa, Maria Mendoza, Dominique Georgiou, Teresa Lockett, Jose Martinez, Elena Perez, Veronica Gallardo Sanchez, Giuseppe Scozzafava, Alberto Sobrinodiaz, Hannah Thraves, Etienne Joly
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Serological detection of antibodies against SARS-CoV-2 can help establish rates of seroconversion. Here the authors develop a red cell agglutination test to detect antibodies against the receptor binding domain for distribution free of charge to qual
Externí odkaz:
https://doaj.org/article/b760dbce11dc471eb4678ce36cb1f7a4
Autor:
Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Background To understand the kinetics of immune responses with different dosing gaps of the AZD1222 vaccine, we compared antibody and T cell responses in two cohorts with two different dosing gaps. Methods Antibodies to the SARS‐CoV‐2 vi
Externí odkaz:
https://doaj.org/article/9d4a80cf4a59483e9dcd3f2dc549092e