Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lisa Samuelsen"'
Publikováno v:
Samuelsen, L, Larsen, D, Schönbeck, C & Beeren, S R 2022, ' pH-Responsive templates modulate the dynamic enzymatic synthesis of cyclodextrins ', Chemical Communications, vol. 58, pp. 5152-5155 . https://doi.org/10.1039/d1cc06554h
Product selection in the dynamic enzymatic synthesis of cyclodextrins can be controlled by changing the pH. Using cyclodextrin glucanotransferase to make labile the glycosidic linkages in cyclodextrins (CDs), we generate a dynamic combinatorial libra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffeb5ed6d2c682d5288632fd72cd2c4
https://doi.org/10.1039/d1cc06554h
https://doi.org/10.1039/d1cc06554h
Publikováno v:
Samuelsen, L, Holm, R & Schönbeck, C 2022, ' Exploring the interactions between buffers and cyclodextrin complexes—formation of regular inclusion or atypical non-inclusion complexes ', Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 102, pp. 151-158 . https://doi.org/10.1007/s10847-021-01111-4
The aim of this study was for the first time to determine the effect of 11 buffers on a γ-cyclodextrin complex, and use these and previous reported data to systematically explore the effect of buffers on different cyclodextrin complexes, considering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3773c93359e645867e9b4cd9f492277
https://doi.org/10.1007/s10847-021-01111-4
https://doi.org/10.1007/s10847-021-01111-4
Publikováno v:
Samuelsen, L, Holm, R & Schönbeck, C 2021, ' Simultaneous determination of cyclodextrin stability constants as a function of pH and temperature – A tool for drug formulation and process design ', Journal of Drug Delivery Science and Technology, vol. 65, 102675 . https://doi.org/10.1016/j.jddst.2021.102675
The stability constant for complex formation is an important physicochemical property used to guide drug formulation development with cyclodextrins. Complex formation depends on both pH and temperature, factors often altered during pharmaceutical pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e469d05e6ebb1799cfac0f8ebaadb9
https://findresearcher.sdu.dk:8443/ws/files/184504482/1_s2.0_S1773224721003555_main.pdf
https://findresearcher.sdu.dk:8443/ws/files/184504482/1_s2.0_S1773224721003555_main.pdf
Publikováno v:
International Journal of Pharmaceutics. 560:357-364
Solution pH is an important factor during drug formulation and processing. Changes in pH present challenges. Regulation of pH is typically managed by using a buffer system, which must have a suitable pKa. The pKa of buffers depends on temperature, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38074bd2b743351f0cf1194414018fe6
https://doi.org/10.1016/j.ijpharm.2019.02.019
https://doi.org/10.1016/j.ijpharm.2019.02.019
Publikováno v:
Journal of pharmaceutical sciences. 110(7)
The effect of 11 buffers as well as the effect of ionic strength were investigated on the binding between the bile salt taurochenodeoxycholate and the ionic sulfobutylether-β-cyclodextrin. The investigations showed that both ionic strength and compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9b300c816dbd4a4094f1c5ada254ab
https://pubmed.ncbi.nlm.nih.gov/33607189
https://pubmed.ncbi.nlm.nih.gov/33607189
Publikováno v:
International journal of pharmaceutics. 589
Thirteen buffers were investigated for their effect on the binding of adamantanol to β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Stability constants for the β-cyclodextrin complex ranged from 14,800 to 46,000 M−1, and the binding enthalpies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7472a0a108836e1e7eb9d4dbed7bb243
https://pubmed.ncbi.nlm.nih.gov/32916213
https://pubmed.ncbi.nlm.nih.gov/32916213
Publikováno v:
International journal of pharmaceutics. 585
Complex formation between cyclodextrins and ionizable guest molecules depends on pH. In general, the neutral species of an ionizable guest molecule has the highest affinity for the cyclodextrin cavity, but ionized species will also be able to form co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c56d039d352384dd35c7d5b79d8dd6
https://pubmed.ncbi.nlm.nih.gov/32502687
https://pubmed.ncbi.nlm.nih.gov/32502687
Usnic acid has anti-cancer activity, however, low solubility and toxicity limit the potential. To investigate biological activity of usnic acid derivatives, enantiopure derivatives were synthesised by reacting usnic acid with ethylenediamine, which y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadb2f5d974fa3207ac78d1e63c55031
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 184
The advantage of isothermal titration calorimetry (ITC) to determine the acid dissociation constant (pKa value) is the simultaneous determination of the binding constant and binding enthalpy, as well as being precise and easy to use. The pKa can be c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc73ebd17b3e18ef4fc4021c1cfd781f
https://pubmed.ncbi.nlm.nih.gov/32126458
https://pubmed.ncbi.nlm.nih.gov/32126458
Publikováno v:
International journal of pharmaceutics. 568
In drug formulations, cyclodextrins are used to increase aqueous solubility and chemical stability of drugs via formation of inclusion complexes. For ionizable drug molecules, the complexation strength depends on pH. Increased ionization leads to a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca6dc4c06efaca2c6fb89cf38f428e1
https://pubmed.ncbi.nlm.nih.gov/31319150
https://pubmed.ncbi.nlm.nih.gov/31319150