Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lisa Sach-Peltason"'
Autor:
Simon J. Crouzet, Anja Maria Lieberherr, Kenneth Atz, Tobias Nilsson, Lisa Sach-Peltason, Alex T. Müller, Matteo Dal Peraro, Jitao David Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2872-2882 (2024)
Protein–ligand interactions (PLIs) determine the efficacy and safety profiles of small molecule drugs. Existing methods rely on either structural information or resource-intensive computations to predict PLI, casting doubt on whether it is possible
Externí odkaz:
https://doaj.org/article/706aaa4c8b7f494480f6a524cfbe1b08
Autor:
Li Wang, Qihui Zhu, Jitao David Zhang, Yaling Zhang, Xiaoju Ni, Kunlun Xiang, Jiaxi Jiang, Baocun Li, Youjun Yu, Hui Hu, Meifang Zhang, Waikwong Wu, Jing Zeng, Zhipeng Yan, Jieyu Dai, Kai Sun, Xin Zhang, Dongdong Chen, Song Feng, Lisa Sach-Peltason, John A.T. Young, Lu Gao
Publikováno v:
Journal of Hepatology. 78:742-753
The persistence of covalently closed circular DNA (cccDNA) in infected hepatocytes is the major barrier preventing viral eradication with existing therapies in patients with chronic hepatitis B (CHB). Therapeutic agents that can eliminate cccDNA are
Autor:
Raya Stoyanova, Paul Maximilian Katzberger, Leonid Komissarov, Aous Khadhraoui, Lisa Sach-Peltason, Katrin Groebke Zbinden, Torsten Schindler, Nenad Manevski
Publikováno v:
Journal of Chemical Information and Modeling. 63:442-458
Although computational predictions of pharmacokinetics (PK) are desirable at the drug design stage, existing approaches are often limited by prediction accuracy and human interpretability. Using a discovery data set of mouse and rat PK studies at Roc
Autor:
Leonard D. Goldstein, Filip Roudnicky, Bo Kyoung Kim, Claas A. Meyer, Lisa Sach-Peltason, Nikhil J. Pandya, Klaus Christensen, Christoph Patsch, Héloïse Ragelle, Oliv Eidam, Chad A. Cowan, Martin Graf, Pamela Strassburger, Zora Modrusan, Mark Burcin, Balazs Banfai, Verena Kueppers, Manuel Tzouros, Mirjana Lazendic, Sabine Uhles, Gregor Sturm, Peter D. Westenskow, Franco Revelant, Yanjun Lan, Jitao David Zhang, Sabine Gruener
Publikováno v:
Proc Natl Acad Sci U S A
The blood–retina barrier and blood–brain barrier (BRB/BBB) are selective and semipermeable and are critical for supporting and protecting central nervous system (CNS)-resident cells. Endothelial cells (ECs) within the BRB/BBB are tightly coupled,
Autor:
Manuela Jaklin, Claudia McGinnis, Erich Kueng, Paul Barrow, Lisa Sach-Peltason, Marcel Leist, Stefan Kustermann, Jitao David Zhang, Nicole Schaefer, Nicole Clemann
Publikováno v:
Toxicological Sciences
Teratogenicity poses severe threats to patient safety. Stem-cell-based in vitro systems are promising tools to predict human teratogenicity. However, current in vitro assays are limited because they either capture effects on a certain germ layer, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb95219af3a197bc5805d486b9c288ab
https://doi.org/10.1101/2021.07.06.451364
https://doi.org/10.1101/2021.07.06.451364
Autor:
Lynne M. Bird, Lisa Sach-Peltason, Mark Nespeca, Wen-Hann Tan, Daiana Cassater, Joerg F. Hipp, Mariana Bustamante, Alexander Rotenberg
Publikováno v:
Pediatr Neurol
BACKGROUND Epilepsy is highly prevalent in children with Angelman syndrome (AS), and its detailed characterization and relationship to the genotype (deletion vs nondeletion) is important both for medical practice and for clinical trial design. METHOD
Publikováno v:
Drug discovery today. 25(3)
Here, we introduce models at three levels-molecular level, cellular and omics level, and organ and system level-that study drug mechanism and safety in preclinical drug discovery. The models differ in both their scope of study and technical details,
Publikováno v:
Laboratory Animals. 51:44-53
The cannulation of the cisterna magna in rats for in vivo sampling of cerebrospinal fluid serves as a valuable model for studying the delivery of new drugs into the central nervous system or disease models. It offers the advantages of repeated sampli
Publikováno v:
Journal of Chemical Information and Modeling, 54(9), 2395-2401. American Chemical Society
The calculation of pairwise compound similarities based on fingerprints is one of the fundamental tasks in chemoinformatics. Methods for efficient calculation of compound similarities are of utmost importance for various applications like similarity