Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Lisa S. St. John"'
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target
Autor:
Maliha Khan, Selena Carmona, Pariya Sukhumalchandra, Jason Roszik, Anne Philips, Alexander A. Perakis, Celine Kerros, Mao Zhang, Na Qiao, Lisa S. St. John, Madhushree Zope, Jonathan Goldberg, Mariam Qazilbash, Haroon Jakher, Karen Clise-Dwyer, Yihua Qiu, Elizabeth A. Mittendorf, Jeffrey J. Molldrem, Steven M. Kornblau, Gheath Alatrash
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. We previously identified CG1 (FLLPTGAEA), a human leukocyte antigen-A2-restricted nonameric peptide deri
Externí odkaz:
https://doaj.org/article/b6df8da3c28b4eaa907aea2ac7cee27d
Autor:
Jeffrey J. Molldrem, Samir Hanash, Gheath Alatrash, Chantale Bernatchez, Stephen G. Swisher, John V. Heymach, Don L. Gibbons, Jason Roszik, Karen Clise-Dwyer, Kathryn Ruisaard, Mourad Majidi, Boris Sepesi, Jack A. Roth, Ismail M. Meraz, Lorenzo Federico, Lisa S. St. John, Haven R. Garber, Hiroyuki Katayama, Celine Kerros, Satyendra C. Tripathi, Haley L. Peters
Supplementary Figure S1. Lung cancer cell lines do not express NE and P3 gene transcripts. Supplementary Figure S2. CTL proliferate in the presence of NE-exposed lung cancer cells. Supplementary Figure S3. HLA class I presentation of mutant neoantige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2c731ad70e3270e82cab95deaa7b6d
https://doi.org/10.1158/2326-6066.22538360
https://doi.org/10.1158/2326-6066.22538360
Autor:
Jeffrey J. Molldrem, Samir Hanash, Gheath Alatrash, Chantale Bernatchez, Stephen G. Swisher, John V. Heymach, Don L. Gibbons, Jason Roszik, Karen Clise-Dwyer, Kathryn Ruisaard, Mourad Majidi, Boris Sepesi, Jack A. Roth, Ismail M. Meraz, Lorenzo Federico, Lisa S. St. John, Haven R. Garber, Hiroyuki Katayama, Celine Kerros, Satyendra C. Tripathi, Haley L. Peters
Immunotherapies targeting immune checkpoints have proven efficacious in reducing the burden of lung cancer in patients; however, the antigenic targets of these reinvigorated T cells remain poorly defined. Lung cancer tumors contain tumor-associated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49907a10f07f5f09abe1a4ce9f79bc7
https://doi.org/10.1158/2326-6066.c.6548756.v1
https://doi.org/10.1158/2326-6066.c.6548756.v1
Autor:
Jeffrey J. Molldrem, Samir Hanash, Gheath Alatrash, Chantale Bernatchez, Stephen G. Swisher, John V. Heymach, Don L. Gibbons, Jason Roszik, Karen Clise-Dwyer, Kathryn Ruisaard, Mourad Majidi, Boris Sepesi, Jack A. Roth, Ismail M. Meraz, Lorenzo Federico, Lisa S. St. John, Haven R. Garber, Hiroyuki Katayama, Celine Kerros, Satyendra C. Tripathi, Haley L. Peters
Figure Legends for Supplementary Figures S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee9147779faa94ee49c5a8f0c8aefa2
https://doi.org/10.1158/2326-6066.22538363.v1
https://doi.org/10.1158/2326-6066.22538363.v1
Autor:
Jeffrey J. Molldrem, Qing Ma, Elizabeth A. Mittendorf, Karen Clise-Dwyer, Sijie Lu, Lisa S. St John, Jinsheng Weng, Na Qiao, Haven R. Garber, Amanda M. Cernosek, Anne V. Philips, Ken H. Young, Shuhua Yi, Anna Sergeeva, Rebecca Patenia, Madhushree Zope, Haroon Jakher, Mao Zhang, Pariya Sukhumalchandra, Haley L. Peters, Celine Kerros, Alexander A. Perakis, Gheath Alatrash
U266 cross-presents PR1 after exposure to NE/P3 from PMN co-culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b70c375f1c18d1e168a3d75786a998b
https://doi.org/10.1158/1078-0432.22464956.v1
https://doi.org/10.1158/1078-0432.22464956.v1
Autor:
Gheath Alatrash, Paul M. Armistead, Gary L. Glish, Jeffrey J. Molldrem, Sijie Lu, Karen Clise-Dwyer, Gregory Lizee, Tania Rodriguez-Cruz, Haroon Jakher, Patricia A. Ropp, Zein Al-Atrache, Kathryn Ruisaard, Anna Sergeeva, Elizabeth A. Mittendorf, Sally A. Hunsucker, Lisa S. St. John, Atim A. Enyenihi, Pariya Sukhumalchandra, Mao Zhang
PDF file - 706k, Figure S1. CG is ubiquitinated in AML. Figure S2. CG1 is a naturally processed epitope that is eluted from leukemia cell surface. Figure S3. CG expression by each of the AML samples used in the cytotoxicity assays. Figure S4. Gating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47741c7caa16f27bfcbc2ae8a6ef06d
https://doi.org/10.1158/1078-0432.22449288
https://doi.org/10.1158/1078-0432.22449288
Autor:
Elizabeth A. Mittendorf, Elizabeth J. Shpall, Qing Ma, Jeffrey J. Molldrem, Willem W. Overwijk, Steve Wolpe, Leonard P. Miller, Karen Clise-Dwyer, Hiep Khong, Maria R. Khouri, Lisa S. St. John, Celine Kerros, Haven R. Garber, Anne V. Philips, Pariya Sukhumalchandra, Alexander A. Perakis, Madhushree Zope, Mao Zhang, Na Qiao, Gheath Alatrash
Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa351cde25fe8ad9c89a5ecafe8c9354
https://doi.org/10.1158/1078-0432.22474350
https://doi.org/10.1158/1078-0432.22474350
Autor:
Elizabeth A. Mittendorf, Elizabeth J. Shpall, Qing Ma, Jeffrey J. Molldrem, Willem W. Overwijk, Steve Wolpe, Leonard P. Miller, Karen Clise-Dwyer, Hiep Khong, Maria R. Khouri, Lisa S. St. John, Celine Kerros, Haven R. Garber, Anne V. Philips, Pariya Sukhumalchandra, Alexander A. Perakis, Madhushree Zope, Mao Zhang, Na Qiao, Gheath Alatrash
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f10cabf1040e71aeb33eae06cdbb57e
https://doi.org/10.1158/1078-0432.22474353.v1
https://doi.org/10.1158/1078-0432.22474353.v1
Autor:
Elizabeth A. Mittendorf, Elizabeth J. Shpall, Qing Ma, Jeffrey J. Molldrem, Willem W. Overwijk, Steve Wolpe, Leonard P. Miller, Karen Clise-Dwyer, Hiep Khong, Maria R. Khouri, Lisa S. St. John, Celine Kerros, Haven R. Garber, Anne V. Philips, Pariya Sukhumalchandra, Alexander A. Perakis, Madhushree Zope, Mao Zhang, Na Qiao, Gheath Alatrash
Purpose:Inefficient homing of adoptively transferred cytotoxic T lymphocytes (CTLs) to tumors is a major limitation to the efficacy of adoptive cellular therapy (ACT) for cancer. However, through fucosylation, a process whereby fucosyltransferases (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa176901ab9a8c0df267a836694ee3b
https://doi.org/10.1158/1078-0432.c.6528759
https://doi.org/10.1158/1078-0432.c.6528759
Autor:
Gheath Alatrash, Paul M. Armistead, Gary L. Glish, Jeffrey J. Molldrem, Sijie Lu, Karen Clise-Dwyer, Gregory Lizee, Tania Rodriguez-Cruz, Haroon Jakher, Patricia A. Ropp, Zein Al-Atrache, Kathryn Ruisaard, Anna Sergeeva, Elizabeth A. Mittendorf, Sally A. Hunsucker, Lisa S. St. John, Atim A. Enyenihi, Pariya Sukhumalchandra, Mao Zhang
Purpose: Immunotherapy targeting aberrantly expressed leukemia-associated antigens has shown promise in the management of acute myeloid leukemia (AML). However, because of the heterogeneity and clonal evolution that is a feature of myeloid leukemia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439b673e0ba53abeeb3fbd95e627c6
https://doi.org/10.1158/1078-0432.c.6521610
https://doi.org/10.1158/1078-0432.c.6521610