Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lisa Rauschenberger"'
Autor:
Susanne Knorr, Lisa Rauschenberger, Muthuraman Muthuraman, Rhonda McFleder, Thomas Ott, Kathrin Grundmann-Hauser, Takahiro Higuchi, Jens Volkmann, Chi Wang Ip
Publikováno v:
Neurobiology of Disease, Vol 194, Iss , Pp 106462- (2024)
DYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a “second hit” DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phen
Externí odkaz:
https://doaj.org/article/e3e0427f360e46b5810d1e70a6ce8c05
Autor:
Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Rauschenberger, Muthuraman Muthuraman, Panagiota Arampatzi, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106453- (2024)
DYT-TOR1A dystonia is the most common monogenic dystonia characterized by involuntary muscle contractions and lack of therapeutic options. Despite some insights into its etiology, the disease's pathophysiology remains unclear. The reduced penetrance
Externí odkaz:
https://doaj.org/article/75730ac91a984c17901626e8ba00be1c
Autor:
Lisa Rauschenberger, Chi Wang Ip
Publikováno v:
Dystonia, Vol 3 (2024)
Dystonia is a network disorder presumed to result from abnormalities in multiple brain regions and in multiple cell populations. The specific pathomechanisms affecting the motor circuits in dystonia are, however, still largely unclear. Animal models
Externí odkaz:
https://doaj.org/article/d7060f18edbf42579eee5c4e79e7e23e
Autor:
Lisa Rauschenberger, Esther-Marie Krenig, Alea Stengl, Susanne Knorr, Tristan H. Harder, Felix Steeg, Maximilian U. Friedrich, Kathrin Grundmann-Hauser, Jens Volkmann, Chi Wang Ip
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106056- (2023)
The relationship between genotype and phenotype in DYT-TOR1A dystonia as well as the associated motor circuit alterations are still insufficiently understood. DYT-TOR1A dystonia has a remarkably reduced penetrance of 20–30%, which has led to the se
Externí odkaz:
https://doaj.org/article/69a317db0e5a4ee98ff484e42030a71d
Autor:
Lisa Rauschenberger, Jennifer Behnke, Alexander Grotemeyer, Susanne Knorr, Jens Volkmann, Chi Wang Ip
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105798- (2022)
The pathogenesis of Parkinson's disease (PD) is closely interwoven with the process of aging. Moreover, increasing evidence from human postmortem studies and from animal models for PD point towards inflammation as an additional factor in disease deve
Externí odkaz:
https://doaj.org/article/1906fbb022e44b96a370c59e42505ab0
Second hit hypothesis in dystonia: Dysfunctional cross talk between neuroplasticity and environment?
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105511- (2021)
One of the great mysteries in dystonia pathophysiology is the role of environmental factors in disease onset and development. Progress has been made in defining the genetic components of dystonic syndromes, still the mechanisms behind the discrepant
Externí odkaz:
https://doaj.org/article/003c42a8ab5644169e660e1d5a844b56
Autor:
Susanne Knorr, Lisa Rauschenberger, Uri Ramirez Pasos, Maximilian U. Friedrich, Robert L. Peach, Kathrin Grundmann-Hauser, Thomas Ott, Aet O'Leary, Andreas Reif, Philip Tovote, Jens Volkmann, Chi Wang Ip
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105337- (2021)
TOR1A is the most common inherited form of dystonia with still unclear pathophysiology and reduced penetrance of 30–40%. ∆ETorA rats mimic the TOR1A disease by expression of the human TOR1A mutation without presenting a dystonic phenotype. We aim
Externí odkaz:
https://doaj.org/article/8c06d0bbd2204284a3bf0ac22fbea2a6
Autor:
Lisa Rauschenberger, Christopher Güttler, Jens Volkmann, Andrea A. Kühn, Chi Wang Ip, Roxanne Lofredi
Publikováno v:
Experimental neurology 355, 114140 (2022). doi:10.1016/j.expneurol.2022.114140
Intracerebral recordings from movement disorders patients undergoing deep brain stimulation have allowed the identification of pathophysiological patterns in oscillatory activity that correlate with symptom severity. Changes in oscillatory synchrony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541b34e175f2616bee06a1245a74f8c9
Publikováno v:
Journal of Visualized Experiments.
The induction of a peripheral nerve injury is a widely used method in neuroscience for the assessment of repair and pain mechanisms among others. In addition, in the research field of movement disorders, sciatic crush injury has been employed to trig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d89b71889c2bb3802c06b605e5fa5f
https://doi.org/10.3791/62606-v
https://doi.org/10.3791/62606-v
Publikováno v:
Journal of Visualized Experiments.
Genetically modified mouse models face limitations, especially when studying movement disorders, where most of the available transgenic rodent models do not present a motor phenotype resembling the clinical aspects of the human disease. Pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045c2b4fa6645276dea994fea755c251
https://doi.org/10.3791/61635-v
https://doi.org/10.3791/61635-v