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pro vyhledávání: '"Lisa Rathgeb"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 47:663-667
Thrombin plays a pivotal role in the pathophysiology of acute coronary syndromes by mediating thrombus formation and endothelium-dependent vasomotor dysfunction. In human endothelial cells, prolonged incubation with thrombin down-regulates endothelia
Autor:
Thomas F. Lüscher, Hana Joch, Masato Eto, Toshiyuki Kozai, Zhihong Yang, Christine Barandier, Lisa Rathgeb
Publikováno v:
Circulation Research. 89:583-590
Abstract— An imbalance of nitric oxide and endothelin plays an important role in cardiovascular disease. Thrombin exerts profound effects on endothelial function. The present study investigated the molecular mechanisms by which thrombin regulates e