Výsledky vyhledávání - "Lisa Rahnfeld"

Akademický článek

Injectable Lipid-Based Depot Formulations: Where Do We Stand?

Publikováno v: Pharmaceutics, Vol 12, Iss 6, p 567 (2020)

The remarkable number of new molecular entities approved per year as parenteral drugs, such as biologics and complex active pharmaceutical ingredients, calls for innovative and tunable drug delivery systems. Besides making these classes of drugs avai

Externí odkaz: https://doaj.org/article/04fb9c2e31b6493ea43461f5a834fca5

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Development and in vivo validation of phospholipid-based depots for the sustained release of bupivacaine

Autor: Simone Aleandri, Lisa Rahnfeld, Despo Chatzikleanthous, Alessandra Bergadano, Claudia Bühr, Carlotta Detotto, Sara Fuochi, Kevin Weber-Wilk, Stefan Schürch, Peter van Hoogevest, Paola Luciani

Publikováno v: Aleandri, Simone; Rahnfeld, Lisa; Chatzikleanthous, Despo; Bergadano, Alessandra; Bühr, Claudia; Detotto, Carlotta; Fuochi, Sara; Weber-Wilk, Kevin; Schürch, Stefan; van Hoogevest, Peter; Luciani, Paola (2022). Development and in vivo validation of phospholipid-based depots for the sustained release of bupivacaine. European journal of pharmaceutics and biopharmaceutics, 181, pp. 300-309. Elsevier 10.1016/j.ejpb.2022.11.019

By direct deposition of the drug at the local site of action, injectable depot formulations - intended for treatment of a local disease or for local intervention - are designed to limit the immediate exposure of the active principle at a systemic lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97837022c8d8a5c8e8addfcc57f0b967

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Immobilization of plasmids in bacterial nanocellulose as gene activated matrix

Autor: Yvette Pötzinger, Lisa Rahnfeld, Dagmar Fischer, Dana Kralisch

Publikováno v: Carbohydrate Polymers. 209:62-73

The synergy of the local delivery of nucleic acids using a hydrogel-based gene activated matrix (GAM) might support regenerative processes on a genetic level by concurrently providing a cell-friendly microenvironment. To investigate bacterial nanocel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08430d6af4685014e69d49fca46a519
https://doi.org/10.1016/j.carbpol.2019.01.009

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Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation

Autor: Paola Luciani, Peter van Hoogevest, Lisa Rahnfeld, Jana Thamm, Frank Steiniger

Publikováno v: Colloids and Surfaces B: Biointerfaces. 168:10-17

Compared to conventional parenteral formulations injectable depot formulations, owing to a sustained drug release, offer several advantages, such as a reduced dosing frequency - and consequent improved compliance - or a predictable release profile. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2691237ee3565ed1b117a08a087190
https://doi.org/10.1016/j.colsurfb.2018.02.023

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Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival

Autor: Jean-Christophe Prost, Cédric Bovet, Jan A. Plock, Esther Vögelin, Jonas T. Schnider, Robert Rieben, Yara Banz, Damian Sutter, Adriano Taddeo, Dzhuliya V. Dzhonova, Paola Luciani, Lisa Rahnfeld, Jean-Christophe Leroux

Publikováno v: Sutter, Damian; Dzhonova, Dzhuliya V.; Prost, Jean-Christophe; Bovet, Cedric; Banz, Yara; Rahnfeld, Lisa; Leroux, Jean-Christophe; Rieben, Robert; Vögelin, Esther; Plock, Jan A.; Luciani, Paola; Taddeo, Adriano; Schnider, Jonas T. (2019). Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival. Scientific reports, 9(1), p. 9269. Springer Nature 10.1038/s41598-019-45759-y
Scientific Reports
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

Vascularized composite allotransplantation (VCA), such as hand and face transplantation, is emerging as a potential solution in patients that suffered severe injuries. However, adverse effects of chronic high-dose immunosuppression regimens strongly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2c0961ac23e8d2d95c3b20f25734ff
https://doi.org/10.1038/s41598-019-45759-y

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Analytical profiling and stability evaluation of liposomal drug delivery systems: A rapid UHPLC-CAD-based approach for phospholipids in research and quality control

Autor: Florian Weber, Lisa Rahnfeld, Paola Luciani

Publikováno v: Weber, Florian; Rahnfeld, Lisa; Luciani, Paola (2020). Analytical profiling and stability evaluation of liposomal drug delivery systems: a rapid UHPLC-CAD-based approach for phospholipids in research and quality control. Talanta, 220, p. 121320. Elsevier 10.1016/j.talanta.2020.121320

Phospholipids and their derivatives represent a broad range of multifunctional substances used as excipients or active ingredients by different industries due to their natural origin and unique properties. A fast and reliable quantification as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0d8ffb85d541f9634ef7a74573aead
https://doi.org/10.1016/j.talanta.2020.121320

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