Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lisa Prendergast"'
Autor:
Rebecca J. Harris, Maninder Heer, Mark D. Levasseur, Tyrell N. Cartwright, Bethany Weston, Jennifer L. Mitchell, Jonathan M. Coxhead, Luke Gaughan, Lisa Prendergast, Daniel Rico, Jonathan M. G. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Histone modifications influence the recruitment of reader proteins to chromosomes to regulate events including transcription and cell division. The idea of a histone code, where combinations of modifications specify unique downstream functio
Externí odkaz:
https://doaj.org/article/7bc3ec07d76b40a6a92788fa320dd0b0
Autor:
Lisa Prendergast, Urszula L. McClurg, Rossitsa Hristova, Rolando Berlinguer-Palmini, Sarah Greener, Katie Veitch, Inmaculada Hernandez, Philippe Pasero, Daniel Rico, Jonathan M. G. Higgins, Anastas Gospodinov, Manolis Papamichos-Chronakis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex pr
Externí odkaz:
https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
Autor:
Carsten Dornblut, Nadine Quinn, Shamci Monajambashi, Lisa Prendergast, Chelly van Vuuren, Sandra Münch, Wen Deng, Heinrich Leonhardt, M. Cristina Cardoso, Christian Hoischen, Stephan Diekmann, Kevin F. Sullivan
Publikováno v:
Open Biology, Vol 4, Iss 2 (2014)
The functional identity of centromeres arises from a set of specific nucleoprotein particle subunits of the centromeric chromatin fibre. These include CENP-A and histone H3 nucleosomes and a novel nucleosome-like complex of CENPs -T, -W, -S and -X. F
Externí odkaz:
https://doaj.org/article/e51a9a64a0ab477286fa5e4aca964fd7
Autor:
Lisa Prendergast, Chelly van Vuuren, Agnieszka Kaczmarczyk, Volker Doering, Daniela Hellwig, Nadine Quinn, Christian Hoischen, Stephan Diekmann, Kevin F Sullivan
Publikováno v:
PLoS Biology, Vol 9, Iss 6, p e1001082 (2011)
Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organ
Externí odkaz:
https://doaj.org/article/a8dfbd0ee36d4c4bb9f5318d0d8ea666
Autor:
Jonathan M.G. Higgins, Rolando Berlinguer-Palmini, Daniel Rico, Rossitsa Hristova, Inmaculada Hernandez, Anastas Gospodinov, Urszula L. McClurg, Manolis Papamichos-Chronakis, Philippe Pasero, Sarah Greener, Lisa Prendergast, Katie Veitch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94863d6502252d0111047beb6f4559a7
https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
Publikováno v:
Cancers
Volume 12
Issue 4
Cancers, Vol 12, Iss 878, p 878 (2020)
Volume 12
Issue 4
Cancers, Vol 12, Iss 878, p 878 (2020)
PARP inhibition results in the accumulation of DNA SSBs, causing replication stress (RS) and lesions that can only be resolved by homologous recombination repair (HRR). Defects in HRR, e.g., due to BRCA2 mutation, confer profound sensitivity to PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d239595004a6f4d466d10a8621632d83
Publikováno v:
Cancers
PARP inhibition results in the accumulation of DNA SSBs, causing replication stress (RS) and lesions that can only be resolved by homologous recombination repair (HRR). Defects in HRR, e.g., due to BRCA2 mutation, confer profound sensitivity to PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d2552de98fae6d641296619ca904f71
https://pubmed.ncbi.nlm.nih.gov/32260355
https://pubmed.ncbi.nlm.nih.gov/32260355
Autor:
Garry Pairaudeau, Michael J. Waring, Louis F Valente, Lisa Prendergast, Andrew Madin, James H. Hunter
Publikováno v:
Bioconjugate chemistry. 31(1)
DNA encoded chemical libraries provide a highly efficient means of screening vast numbers of small molecules against an immobilized protein target. Their potential is currently restricted by the constraints of carrying out library synthesis in the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a16f897ebbd0a494e67dc6339bb593
https://pubmed.ncbi.nlm.nih.gov/31873005
https://pubmed.ncbi.nlm.nih.gov/31873005
Autor:
Huw D. Thomas, Celine Cano, Anderson J. Ryan, M. Raymond V. Finlay, Yanyan Jiang, Yan Zhao, Helen L. Reeves, Nicole Phillips, Luiza Madia Lourenco, Catherine E. Willoughby, Gesa Junge, David R. Newell, Joanne M. Munck, Anita Wittner, Lisa Prendergast, Roger J. Griffin, Stephen R. Wedge, Tommy Rennison, Suzanne Kyle, Turner Paul, Elaine Willmore, Susan J. Tudhope, James Pickles
Publikováno v:
The Journal of Clinical Investigation
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity as much as tumor toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfec92227f655feda3619c7b6de2be2
Autor:
Andy Lloyd, Patricia Verheyden, Nancy L. Staus, Silvia Singer, Bern Gorecki, Ling-Ling Chew, Cindy Chambers, Anne Solli, Jennifer Lynne Martin, Lynn D. Dierking, Tak-Cheung Lau, John H. Falk, Gabrielle Trepanier, Chantal Barriault, Svein A. Dahl, Mariana Back, Kati Tyystjärvi, Carlos Catalao, Sigrid Falla, Jennifer Santer, Lisa Prendergast Swanger
Publikováno v:
Science Education. 100:849-876
This international investigation was designed to determine if, and under what circumstances experiences at science centers, significantly correlated with a range of adult general public science and technology literacy measures. Given the complex and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79248145da1ddb5d516d115a96ac0a82
https://doi.org/10.1002/sce.21225
https://doi.org/10.1002/sce.21225