Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lisa Polak"'
Autor:
Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli, Samie R Jaffrey, Elaine Fuchs
Publikováno v:
eLife, Vol 9 (2020)
N6-methyladenosine is the most prominent RNA modification in mammals. Here, we study mouse skin embryogenesis to tackle m6A’s functions and physiological importance. We first landscape the m6A modifications on skin epithelial progenitor mRNAs. Cont
Externí odkaz:
https://doaj.org/article/701021811dfb44fe9ddeb33838e2cf41
Autor:
Shaopeng Yuan, Katherine S. Stewart, Yihao Yang, Merve Deniz Abdusselamoglu, S. Martina Parigi, Tamar Y. Feinberg, Karen Tumaneng, Hanseul Yang, John M. Levorse, Lisa Polak, David Ng, Elaine Fuchs
Publikováno v:
Nature. 612:555-563
Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy1–4. At tumour–stromal interfaces, a subset of tumour-initiating progenitors, the cancer stem cells, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425de5bfef61c0d2dc465c1216b9a632
https://doi.org/10.1038/s41586-022-05475-6
https://doi.org/10.1038/s41586-022-05475-6
Autor:
Elaine Fuchs, Katherine S. Stewart, Lynette Hidalgo, Thomas L. Carroll, H. Amalia Pasolli, Yihao Yang, Nicholas C. Gomez, Nicole R. Infarinato, Lisa Polak
Publikováno v:
Genes Dev
Through recurrent bouts synchronous with the hair cycle, quiescent melanocyte stem cells (McSCs) become activated to generate proliferative progeny that differentiate into pigment-producing melanocytes. The signaling factors orchestrating these event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c697536e9c36c50416ca8efaee7a30ee
https://doi.org/10.1101/gad.340281.120
https://doi.org/10.1101/gad.340281.120
Autor:
James G. Krueger, Hanseul Yang, Olivier Elemento, Elaine Fuchs, Lisa Polak, Yang Hu, Nicholas C. Gomez, Shiri Gur-Cohen, Akanksha Verma, Yuxuan Miao, Yejing Ge, Maria Nikolova
Publikováno v:
Proc Natl Acad Sci U S A
Aging manifests with architectural alteration and functional decline of multiple organs throughout an organism. In mammals, aged skin is accompanied by a marked reduction in hair cycling and appearance of bald patches, leading researchers to propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58365e3193e1c790138811b5176038d5
https://doi.org/10.1073/pnas.1901720117
https://doi.org/10.1073/pnas.1901720117
Autor:
Maria Nikolova, Ellen Wong, Matthew T. Tierney, Kevin Andrew Uy Gonzales, Hilda Amalia Pasolli, Shijing Luo, Lisa Polak, Anita Gola, Jesse S S Novak, Nicole R. Infarinato, Siqi Liu, Elaine Fuchs, Irina Matos, Kenneth Lay
Publikováno v:
Science (New York, N.Y.). 374(6571)
Stem cells remember Tissue stem cells sense their surroundings, and this perception influences subsequent fate and function. Gonzales et al . observed that stem cells accumulate epigenetic memories of diverse environmental events (see the Perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5989da4427d41771fbea7cfa44ff4362
https://pubmed.ncbi.nlm.nih.gov/34822297
https://pubmed.ncbi.nlm.nih.gov/34822297
Autor:
Alexander Y. Rudensky, Peter A. Savage, Cynthia Truong, Stanislav Dikiy, John Levorse, Nicole R. Infarinato, Elaine Fuchs, Audrey Gang, Yuxuan Miao, Katherine Stewart, Weijie Guo, Amalia H.A. Pasolli, Liberty Woodside, Lisa Polak
Adult stem cells reside in various tissues to govern homeostasis and repair damage. During wound healing, these stem cells must be mobilized to enter the center of the injury where they are exposed to many inflammatory immune cells infiltrating the w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6f88638f9a462825deb0c57fd29c66
https://doi.org/10.1101/2021.08.16.456570
https://doi.org/10.1101/2021.08.16.456570
Autor:
Lisa Polak, Elaine Fuchs, Thomas L. Carroll, Samie R. Jaffrey, Linghe Xi, Ji-Dung Luo, Irina Matos, H. Amalia Pasolli
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
N6-methyladenosine is the most prominent RNA modification in mammals. Here, we study mouse skin embryogenesis to tackle m6A’s functions and physiological importance. We first landscape the m6A modifications on skin epithelial progenitor mRNAs. Cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fb8d4a2e112e6626044ddf9a5d5085
https://doi.org/10.7554/elife.56980
https://doi.org/10.7554/elife.56980
Autor:
Elaine Fuchs, Hanseul Yang, Daniel S. Oristian, Amma Asare, Deyou Zheng, Samantha B. Larsen, Maria Nikolova, Lisa Polak, Meelis Kadaja, Shira Rockowitz, Rene C. Adam
Publikováno v:
Nature
Adult stem cells occur in niches that balance self-renewal with lineage selection and progression during tissue homeostasis. Following injury, culture or transplantation, stem cells outside their niche often display fate flexibility. Here we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958d9d120598e4ab0e1cb987df296249
https://doi.org/10.1038/nature14289
https://doi.org/10.1038/nature14289
Autor:
Elaine Fuchs, Ping Wang, Wen-Hui Lien, John Levorse, Deyou Zheng, Yejing Ge, Rene C. Adam, Lisa Polak, Hanseul Yang, Sanjeethan C. Baksh, Yilin Zhao
Publikováno v:
Cell Stem Cell, Vol. 22, p. 398-413 (2018)
Tissue regeneration relies on resident stem cells (SCs), whose activity and lineage choices are influenced by the microenvironment. Exploiting the synchronized, cyclical bouts of tissue regeneration in hair follicles (HFs), we investigate how microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14631eb0ddb784bf403a376bab32fe98
https://pubmed.ncbi.nlm.nih.gov/29337183
https://pubmed.ncbi.nlm.nih.gov/29337183