Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lisa Pirrie"'
Autor:
Nicholas J. Westwood, Sonia Lain, Tomas Lebl, Daumantas Matulis, Asta Zubrienė, Anna R. McCarthy, Louise L. Major, Vaida Morkūnaitė, Lisa Pirrie
Publikováno v:
Molecules, Vol 17, Iss 10, Pp 12206-12224 (2012)
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases. Here we describe SAR studies starting from the unselective sirtuin
Externí odkaz:
https://doaj.org/article/671838680b6349c49ea791e5f162cc7d
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 41K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568593bb00a1a2261ad018ca602ae0ea
https://doi.org/10.1158/1535-7163.22498024
https://doi.org/10.1158/1535-7163.22498024
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 178K, Tenovin-D3 causes cell cycle arrest in SirT2 wild type but not knockout cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c66a53bc3efea8b2882ea7dd2e4b2f
https://doi.org/10.1158/1535-7163.22498039
https://doi.org/10.1158/1535-7163.22498039
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 38K, Inhibition of purified SirT1 and SirT2 by tenovin-D3 using FdL substrates at 15 μM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc93a105baf8bf79fea430b1f4321ec
https://doi.org/10.1158/1535-7163.22498048.v1
https://doi.org/10.1158/1535-7163.22498048.v1
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 18K, Retention time of tenovin-D3 = 0.61 minutes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2a0e25fc12b0eb66d71d430169c27d
https://doi.org/10.1158/1535-7163.22498021.v1
https://doi.org/10.1158/1535-7163.22498021.v1
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422111ce2b51272c8c3791a5a66eff2d
https://doi.org/10.1158/1535-7163.22498027
https://doi.org/10.1158/1535-7163.22498027
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 42K, MDAMB468 cells were treated with the indicated amounts of TSA for 6 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a838b7f936b454466bf2e465e4b016
https://doi.org/10.1158/1535-7163.22498030
https://doi.org/10.1158/1535-7163.22498030
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 139K, Cell lines with differing p53 status were treated with TSA for 6 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cb04f78b22598fedeb9007183af6b9
https://doi.org/10.1158/1535-7163.22498036.v1
https://doi.org/10.1158/1535-7163.22498036.v1
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 30K, Tenovin-6 and tenovin-D3 are poor inhibitors of HDAC8 and SirT3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b87ca4466547f13c02767ef224a7c
https://doi.org/10.1158/1535-7163.22498042.v1
https://doi.org/10.1158/1535-7163.22498042.v1
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
While small-molecule inhibitors of class I/II histone deacetylases (HDAC) have been approved for cancer treatment, inhibitors of the sirtuins (a family of class III HDACs) still require further validation and optimization to enter clinical trials. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f23cf5e835db40607f2be3f141be481
https://doi.org/10.1158/1535-7163.c.6535771
https://doi.org/10.1158/1535-7163.c.6535771