Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lisa Pence"'
Autor:
Sudeepa Bhattacharyya, Lisa Pence, Ke Yan, Pritmohinder Gill, Chunqiao Luo, Lynda G. Letzig, Pippa M. Simpson, Gregory L. Kearns, Richard D. Beger, Laura P. James
Publikováno v:
Toxicology Reports, Vol 3, Iss , Pp 747-755 (2016)
Phospholipids are an important class of lipids that act as building blocks of biological cell membranes and participate in a variety of vital cellular functions including cell signaling. Previous studies have reported alterations in phosphatidylcholi
Externí odkaz:
https://doaj.org/article/b6cbf4313fb141c5b3d782eaa4824c7a
Autor:
Jack Hinson, Laura James, Pippa Simpson, Leah Hennings, Ke Yan, Sandra McCullough, Shubhra Chaudhuri, Richard Beger, Lisa Pence, Sudeepa Bhattacharyya
Publikováno v:
Metabolites, Vol 3, Iss 3, Pp 606-622 (2013)
High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glu
Externí odkaz:
https://doaj.org/article/2f44a7d7c21b49a7bbfb4267565d42bf
Autor:
Laura James, Ke Yan, Lisa Pence, Pippa Simpson, Sudeepa Bhattacharyya, Pritmohinder Gill, Lynda Letzig, Gregory Kearns, Richard Beger
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131010 (2015)
Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids
Externí odkaz:
https://doaj.org/article/1f007fc43ba24ccab9588f29c8ecbe4a
Autor:
Feng Wei, Lisa Pence, Kellie Woodling, Prathyusha Bagam, Richard Beger, Goncalo Gamboa da Costa, Li Pang
Publikováno v:
Toxicological Sciences. 188:48-61
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been widely used in the Comprehensive in vitro Proarrhythmia Assay (CiPA). The notable difference of the electrophysiological (EP) responses of hiPSC-CMs in serum and serum-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde653966cc561a779ef2d3bd2782c52
https://doi.org/10.1093/toxsci/kfac043
https://doi.org/10.1093/toxsci/kfac043
Autor:
Zhijun Cao, Jennie Z. Ma, Lisa Pence, Devasmita Choudhury, Didier Portilla, Jaclyn R. Daniels, Richard D. Beger, Laura K. Schnackenberg, Li-Rong Yu, Jinchun Sun, Paul M. Palevsky
Publikováno v:
Kidney360
Background: Acute kidney injury requiring dialysis (AKI-D) is associated with prolonged hospitalization, mortality, and progressive chronic kidney disease (CKD) among survivors. Previous studies have examined only select urine or serum biomarkers for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72250553786e4557647c1e4dd4164207
https://pubmed.ncbi.nlm.nih.gov/34913041
https://pubmed.ncbi.nlm.nih.gov/34913041
Autor:
Jaclyn R. Daniels, Jinchun Sun, Richard D. Beger, Thomas C. Schmitt, Lisa Pence, Mackean Maisha, Antje Wagner-Golbs, Sarah Rogstad, Laura K. Schnackenberg, Li-Rong Yu, Zhijun Cao, Beate Kamlage
Publikováno v:
J Proteome Res
Discrepancies in blood sample collection and processing could have a significant impact on levels of metabolites, peptides, and protein biomarkers of inflammation in the blood; thus, sample quality control is critical for successful biomarker identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d2f4c3205de50b10199d34cfba13b1
https://doi.org/10.1021/acs.jproteome.8b00903
https://doi.org/10.1021/acs.jproteome.8b00903
Publikováno v:
Birth Defects Research. 111:270-280
Background Previously, we evaluated optimal organ culture conditions to produce elongated spermatids in an in vitro mouse testis culture system. However, differences in testicular function between the cultured testis fragments and animal testis have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712e7227fe66c3a247cc60468b6cd842
https://doi.org/10.1002/bdr2.1451
https://doi.org/10.1002/bdr2.1451
Autor:
Joseph P. Hanig, Richard D. Beger, Lisa Pence, James Greenhaw, Tao Han, Vikrant Vijay, Qiang Shi, James C. Fuscoe, Lijun Ren
Publikováno v:
Drug Metabolism and Disposition
Safety assessments of new drug candidates are an important part of the drug development and approval process. Often, possible sex-associated susceptibilities are not adequately addressed, and better assessment tools are needed. We hypothesized that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235be05de187758a8dcfbc0d19133be3
https://pubmed.ncbi.nlm.nih.gov/32193355
https://pubmed.ncbi.nlm.nih.gov/32193355
Autor:
Chunqiao Luo, Lynda Letzig, Pippa Simpson, Gregory L. Kearns, Laura P. James, Pritmohinder S. Gill, Lisa Pence, Richard D. Beger, Ke Yan, Sudeepa Bhattacharyya
Publikováno v:
Toxicology Reports, Vol 3, Iss, Pp 747-755 (2016)
Toxicology Reports
Toxicology Reports
Phospholipids are an important class of lipids that act as building blocks of biological cell membranes and participate in a variety of vital cellular functions including cell signaling. Previous studies have reported alterations in phosphatidylcholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cf256b1c325e05d49dcd95bd96d5d1
http://www.sciencedirect.com/science/article/pii/S2214750016300609
http://www.sciencedirect.com/science/article/pii/S2214750016300609
Autor:
Zhijun Cao, Thomas C. Schmitt, Mackean Maisha, Jaclyn R. Daniels, Beate Kamlage, Jinchun Sun, Richard D. Beger, Laura K. Schnackenberg, Li-Rong Yu, Lisa Pence
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc1b437b989a34397d26abbd6c46a9e
https://doi.org/10.1096/fasebj.2018.32.1_supplement.802.5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.802.5